The Greek Version of the Mild Behavioral Impairment Checklist (MBI-C): Psychometric Properties in Mild Cognitive Impairment Due to Alzheimer’s Disease
Background/Objectives: Mild behavioral impairment (MBI) is an early marker of Alzheimer’s disease (AD) and other neurodegenerative diseases, often preceding cognitive decline. The MBI Checklist (MBI-C) is a 34-item tool designed to detect MBI. This study aimed to assess the psychometric properties o...
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2025-04-01
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| author | Efthalia Angelopoulou Evangelia Stanitsa Maria Hatzopoulou Akylina Despoti Niki Tsinia Vasiliki Kamtsadeli Marina Papadogiani Vasilis Kyriakidis Sokratis Papageorgiou John D. Papatriantafyllou |
| author_facet | Efthalia Angelopoulou Evangelia Stanitsa Maria Hatzopoulou Akylina Despoti Niki Tsinia Vasiliki Kamtsadeli Marina Papadogiani Vasilis Kyriakidis Sokratis Papageorgiou John D. Papatriantafyllou |
| author_sort | Efthalia Angelopoulou |
| collection | DOAJ |
| description | Background/Objectives: Mild behavioral impairment (MBI) is an early marker of Alzheimer’s disease (AD) and other neurodegenerative diseases, often preceding cognitive decline. The MBI Checklist (MBI-C) is a 34-item tool designed to detect MBI. This study aimed to assess the psychometric properties of the Greek version of the MBI-C and its ability to differentiate patients with mild cognitive impairment due to AD (MCI-AD) from cognitively unimpaired older adults (healthy participants, HPs). Methods: A total of 181 participants (104 MCI-AD, 77 HPs) were recruited from the Third Age Day Care Center IASIS (2019–2023), accompanied by a close informant. Participants underwent neuropsychological assessment [Mini-Mental State Examination (MMSE), Addenbrooke’s Cognitive Examination-Revised (ACE-R)], and informants completed the MBI-C. Internal consistency was evaluated using Cronbach’s α and known-group validity was assessed via comparing MBI-C between the MCI-AD and HPs groups. Diagnostic accuracy was determined via receiver operating characteristic (ROC) analysis. Results: The Greek MBI-C showed excellent internal consistency (Cronbach’s α = 0.899). Among its domains, impulse dyscontrol demonstrated the highest reliability (α = 0.901), whereas decreased motivation (α = 0.564) and abnormal perception/thought content (α = 0.617) exhibited lower reliability. MBI-C total and domain scores were significantly higher in patients with MCI-AD than HPs (<i>p</i> < 0.001). The area under the curve (AUC) was 0.871 (optimal cutoff = 9.5), indicating excellent diagnostic performance. Conclusions: Overall, the Greek MBI-C has strong psychometric properties for MCI-AD. Sociocultural factors might influence symptom identification and reporting, particularly in the domains of decreased motivation and abnormal perception/thought content. Future research should investigate its predictive value for dementia conversion and its applicability to other populations, including individuals with subjective cognitive decline and non-AD causes of MCI. |
| format | Article |
| id | doaj-art-1b31723bebc54315bf2eaee2fb3ebf18 |
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| language | English |
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| spelling | doaj-art-1b31723bebc54315bf2eaee2fb3ebf182025-08-20T01:56:17ZengMDPI AGBrain Sciences2076-34252025-04-0115546210.3390/brainsci15050462The Greek Version of the Mild Behavioral Impairment Checklist (MBI-C): Psychometric Properties in Mild Cognitive Impairment Due to Alzheimer’s DiseaseEfthalia Angelopoulou0Evangelia Stanitsa1Maria Hatzopoulou2Akylina Despoti3Niki Tsinia4Vasiliki Kamtsadeli5Marina Papadogiani6Vasilis Kyriakidis7Sokratis Papageorgiou8John D. Papatriantafyllou91st Department of Neurology, Aiginition University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece1st Department of Neurology, Aiginition University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, GreeceThird Age Day Care Center IASIS, 16562 Athens, GreeceThird Age Day Care Center IASIS, 16562 Athens, GreeceThird Age Day Care Center IASIS, 16562 Athens, GreeceThird Age Day Care Center IASIS, 16562 Athens, GreeceThird Age Day Care Center IASIS, 16562 Athens, GreeceThird Age Day Care Center IASIS, 16562 Athens, Greece1st Department of Neurology, Aiginition University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece1st Department of Neurology, Aiginition University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, GreeceBackground/Objectives: Mild behavioral impairment (MBI) is an early marker of Alzheimer’s disease (AD) and other neurodegenerative diseases, often preceding cognitive decline. The MBI Checklist (MBI-C) is a 34-item tool designed to detect MBI. This study aimed to assess the psychometric properties of the Greek version of the MBI-C and its ability to differentiate patients with mild cognitive impairment due to AD (MCI-AD) from cognitively unimpaired older adults (healthy participants, HPs). Methods: A total of 181 participants (104 MCI-AD, 77 HPs) were recruited from the Third Age Day Care Center IASIS (2019–2023), accompanied by a close informant. Participants underwent neuropsychological assessment [Mini-Mental State Examination (MMSE), Addenbrooke’s Cognitive Examination-Revised (ACE-R)], and informants completed the MBI-C. Internal consistency was evaluated using Cronbach’s α and known-group validity was assessed via comparing MBI-C between the MCI-AD and HPs groups. Diagnostic accuracy was determined via receiver operating characteristic (ROC) analysis. Results: The Greek MBI-C showed excellent internal consistency (Cronbach’s α = 0.899). Among its domains, impulse dyscontrol demonstrated the highest reliability (α = 0.901), whereas decreased motivation (α = 0.564) and abnormal perception/thought content (α = 0.617) exhibited lower reliability. MBI-C total and domain scores were significantly higher in patients with MCI-AD than HPs (<i>p</i> < 0.001). The area under the curve (AUC) was 0.871 (optimal cutoff = 9.5), indicating excellent diagnostic performance. Conclusions: Overall, the Greek MBI-C has strong psychometric properties for MCI-AD. Sociocultural factors might influence symptom identification and reporting, particularly in the domains of decreased motivation and abnormal perception/thought content. Future research should investigate its predictive value for dementia conversion and its applicability to other populations, including individuals with subjective cognitive decline and non-AD causes of MCI.https://www.mdpi.com/2076-3425/15/5/462mild behavioral impairmentAlzheimer’s diseasemild cognitive impairmentdementiacognitive declinemild behavioral impairment checklist |
| spellingShingle | Efthalia Angelopoulou Evangelia Stanitsa Maria Hatzopoulou Akylina Despoti Niki Tsinia Vasiliki Kamtsadeli Marina Papadogiani Vasilis Kyriakidis Sokratis Papageorgiou John D. Papatriantafyllou The Greek Version of the Mild Behavioral Impairment Checklist (MBI-C): Psychometric Properties in Mild Cognitive Impairment Due to Alzheimer’s Disease Brain Sciences mild behavioral impairment Alzheimer’s disease mild cognitive impairment dementia cognitive decline mild behavioral impairment checklist |
| title | The Greek Version of the Mild Behavioral Impairment Checklist (MBI-C): Psychometric Properties in Mild Cognitive Impairment Due to Alzheimer’s Disease |
| title_full | The Greek Version of the Mild Behavioral Impairment Checklist (MBI-C): Psychometric Properties in Mild Cognitive Impairment Due to Alzheimer’s Disease |
| title_fullStr | The Greek Version of the Mild Behavioral Impairment Checklist (MBI-C): Psychometric Properties in Mild Cognitive Impairment Due to Alzheimer’s Disease |
| title_full_unstemmed | The Greek Version of the Mild Behavioral Impairment Checklist (MBI-C): Psychometric Properties in Mild Cognitive Impairment Due to Alzheimer’s Disease |
| title_short | The Greek Version of the Mild Behavioral Impairment Checklist (MBI-C): Psychometric Properties in Mild Cognitive Impairment Due to Alzheimer’s Disease |
| title_sort | greek version of the mild behavioral impairment checklist mbi c psychometric properties in mild cognitive impairment due to alzheimer s disease |
| topic | mild behavioral impairment Alzheimer’s disease mild cognitive impairment dementia cognitive decline mild behavioral impairment checklist |
| url | https://www.mdpi.com/2076-3425/15/5/462 |
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