AMPA Receptor Trafficking in Homeostatic Synaptic Plasticity: Functional Molecules and Signaling Cascades
Homeostatic synaptic plasticity is a negative-feedback response employed to compensate for functional disturbances in the nervous system. Typically, synaptic activity is strengthened when neuronal firing is chronically suppressed or weakened when neuronal activity is chronically elevated. At both th...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2012/825364 |
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| author | Guan Wang James Gilbert Heng-Ye Man |
| author_facet | Guan Wang James Gilbert Heng-Ye Man |
| author_sort | Guan Wang |
| collection | DOAJ |
| description | Homeostatic synaptic plasticity is a negative-feedback response employed to compensate for functional disturbances in the nervous system. Typically, synaptic activity is strengthened when neuronal firing is chronically suppressed or weakened when neuronal activity is chronically elevated. At both the whole cell and entire network levels, activity manipulation leads to a global up- or downscaling of the transmission efficacy of all synapses. However, the homeostatic response can also be induced locally at subcellular regions or individual synapses. Homeostatic synaptic scaling is expressed mainly via the regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking and synaptic expression. Here we review the recently identified functional molecules and signaling pathways that are involved in homeostatic plasticity, especially the homeostatic regulation of AMPAR localization at excitatory synapses. |
| format | Article |
| id | doaj-art-1b2fdcab19f74e81b763d14776afaef0 |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-1b2fdcab19f74e81b763d14776afaef02025-08-20T02:02:21ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/825364825364AMPA Receptor Trafficking in Homeostatic Synaptic Plasticity: Functional Molecules and Signaling CascadesGuan Wang0James Gilbert1Heng-Ye Man2Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USADepartment of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USADepartment of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USAHomeostatic synaptic plasticity is a negative-feedback response employed to compensate for functional disturbances in the nervous system. Typically, synaptic activity is strengthened when neuronal firing is chronically suppressed or weakened when neuronal activity is chronically elevated. At both the whole cell and entire network levels, activity manipulation leads to a global up- or downscaling of the transmission efficacy of all synapses. However, the homeostatic response can also be induced locally at subcellular regions or individual synapses. Homeostatic synaptic scaling is expressed mainly via the regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking and synaptic expression. Here we review the recently identified functional molecules and signaling pathways that are involved in homeostatic plasticity, especially the homeostatic regulation of AMPAR localization at excitatory synapses.http://dx.doi.org/10.1155/2012/825364 |
| spellingShingle | Guan Wang James Gilbert Heng-Ye Man AMPA Receptor Trafficking in Homeostatic Synaptic Plasticity: Functional Molecules and Signaling Cascades Neural Plasticity |
| title | AMPA Receptor Trafficking in Homeostatic Synaptic Plasticity: Functional Molecules and Signaling Cascades |
| title_full | AMPA Receptor Trafficking in Homeostatic Synaptic Plasticity: Functional Molecules and Signaling Cascades |
| title_fullStr | AMPA Receptor Trafficking in Homeostatic Synaptic Plasticity: Functional Molecules and Signaling Cascades |
| title_full_unstemmed | AMPA Receptor Trafficking in Homeostatic Synaptic Plasticity: Functional Molecules and Signaling Cascades |
| title_short | AMPA Receptor Trafficking in Homeostatic Synaptic Plasticity: Functional Molecules and Signaling Cascades |
| title_sort | ampa receptor trafficking in homeostatic synaptic plasticity functional molecules and signaling cascades |
| url | http://dx.doi.org/10.1155/2012/825364 |
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