Human Urine as a Noninvasive Source of Kidney Cells
Urine represents an unlimited source of patient-specific kidney cells that can be harvested noninvasively. Urine derived podocytes and proximal tubule cells have been used to study disease mechanisms and to screen for novel drug therapies in a variety of human kidney disorders. The urinary kidney st...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/362562 |
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| author | Fanny Oliveira Arcolino Agnès Tort Piella Elli Papadimitriou Benedetta Bussolati Daniel J. Antonie Patricia Murray Lamberthus van den Heuvel Elena Levtchenko |
| author_facet | Fanny Oliveira Arcolino Agnès Tort Piella Elli Papadimitriou Benedetta Bussolati Daniel J. Antonie Patricia Murray Lamberthus van den Heuvel Elena Levtchenko |
| author_sort | Fanny Oliveira Arcolino |
| collection | DOAJ |
| description | Urine represents an unlimited source of patient-specific kidney cells that can be harvested noninvasively. Urine derived podocytes and proximal tubule cells have been used to study disease mechanisms and to screen for novel drug therapies in a variety of human kidney disorders. The urinary kidney stem/progenitor cells and extracellular vesicles, instead, might be promising for therapeutic treatments of kidney injury. The greatest advantages of urine as a source of viable cells are the easy collection and less complicated ethical issues. However, extensive characterization and in vivo studies still have to be performed before the clinical use of urine-derived kidney progenitors. |
| format | Article |
| id | doaj-art-1b2fb5fe75cf4ee1866567be4a4ffd68 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-1b2fb5fe75cf4ee1866567be4a4ffd682025-08-20T02:02:21ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/362562362562Human Urine as a Noninvasive Source of Kidney CellsFanny Oliveira Arcolino0Agnès Tort Piella1Elli Papadimitriou2Benedetta Bussolati3Daniel J. Antonie4Patricia Murray5Lamberthus van den Heuvel6Elena Levtchenko7Department of Development and Regeneration, Catholic University Leuven, Herestraat 49, 3000 Leuven, BelgiumInstitute of Translational Medicine, University of Liverpool, Crown Street, Liverpool L69 3BX, UKCenter for Molecular Biotechnology, Department of Molecular Biotechnology and Health Sciences, University of Turin, Via Nizza 52, 10126 Turin, ItalyCenter for Molecular Biotechnology, Department of Molecular Biotechnology and Health Sciences, University of Turin, Via Nizza 52, 10126 Turin, ItalyInstitute of Translational Medicine, University of Liverpool, Crown Street, Liverpool L69 3BX, UKInstitute of Translational Medicine, University of Liverpool, Crown Street, Liverpool L69 3BX, UKDepartment of Development and Regeneration, Catholic University Leuven, Herestraat 49, 3000 Leuven, BelgiumDepartment of Development and Regeneration, Catholic University Leuven, Herestraat 49, 3000 Leuven, BelgiumUrine represents an unlimited source of patient-specific kidney cells that can be harvested noninvasively. Urine derived podocytes and proximal tubule cells have been used to study disease mechanisms and to screen for novel drug therapies in a variety of human kidney disorders. The urinary kidney stem/progenitor cells and extracellular vesicles, instead, might be promising for therapeutic treatments of kidney injury. The greatest advantages of urine as a source of viable cells are the easy collection and less complicated ethical issues. However, extensive characterization and in vivo studies still have to be performed before the clinical use of urine-derived kidney progenitors.http://dx.doi.org/10.1155/2015/362562 |
| spellingShingle | Fanny Oliveira Arcolino Agnès Tort Piella Elli Papadimitriou Benedetta Bussolati Daniel J. Antonie Patricia Murray Lamberthus van den Heuvel Elena Levtchenko Human Urine as a Noninvasive Source of Kidney Cells Stem Cells International |
| title | Human Urine as a Noninvasive Source of Kidney Cells |
| title_full | Human Urine as a Noninvasive Source of Kidney Cells |
| title_fullStr | Human Urine as a Noninvasive Source of Kidney Cells |
| title_full_unstemmed | Human Urine as a Noninvasive Source of Kidney Cells |
| title_short | Human Urine as a Noninvasive Source of Kidney Cells |
| title_sort | human urine as a noninvasive source of kidney cells |
| url | http://dx.doi.org/10.1155/2015/362562 |
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