Novel Versus Conventional Sequencing of β-Blockers, Sodium/Glucose Cotransportor 2 Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors, and Mineralocorticoid Receptor Antagonists in Stable Patients With Heart Failure With Reduced Ejection Fraction (NovCon Sequencing Study): Protocol for a Randomized Controlled Trial

Novel Versus Conventional Sequencing of β-Blockers, Sodium/Glucose Cotransportor 2 Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors, and Mineralocorticoid Receptor Antagonists in Stable Patients With Heart Failure With Reduced Ejection Fraction (NovCon Sequencing Study): Protocol for a Randomized Controlled Trial

BackgroundChronic heart failure has high morbidity and mortality, with approximately half of the patients dying within 5 years of diagnosis. Recent additions to the armamentarium of anti–heart failure therapies include angiotensin receptor-neprilysin inhibitors (ARNIs) and so...

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Main Authors: Sumanth Karamchand, Tsungai Chipamaunga, Poobalan Naidoo, Kiolan Naidoo, Virendra Rambiritch, Kevin Ho, Robert Chilton, Kyle McMahon, Rory Leisegang, Hellmuth Weich, Karim Hassan
Format: Article
Language:English
Published: JMIR Publications 2025-03-01
Series:JMIR Research Protocols
Online Access:https://www.researchprotocols.org/2025/1/e44027
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