Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP)
Paratuberculosis progresses more quickly in young red deer than in sheep or cattle. This study describes the clinical, immunological and pathological changes over a 50-week period in fourteen 4-month-old red deer that received heavy oral challenge with Mycobacterium avium subsp. paratuberculosis (MA...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2012/931948 |
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| _version_ | 1850235132069281792 |
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| author | Colin Mackintosh Gary Clark Brendan Tolentino Simon Liggett Geoff de Lisle Frank Griffin |
| author_facet | Colin Mackintosh Gary Clark Brendan Tolentino Simon Liggett Geoff de Lisle Frank Griffin |
| author_sort | Colin Mackintosh |
| collection | DOAJ |
| description | Paratuberculosis progresses more quickly in young red deer than in sheep or cattle. This study describes the clinical, immunological and pathological changes over a 50-week period in fourteen 4-month-old red deer that received heavy oral challenge with Mycobacterium avium subsp. paratuberculosis (MAP). At 4 and 12 weeks post challenge they were anaesthetized and a section of jejunal lymph node was surgically removed for culture, histopathology, and genetic studies. All 14 deer became infected, none were clinically affected, and they had varying degrees of subclinical disease when killed at week 50. Week 4 biopsies showed no paratuberculosis lesions, but MAP was cultured from all animals. At weeks 12 and 50 histopathological lesions ranged from mild to severe with corresponding low-to-high antibody titres, which peaked at 12–24 weeks. IFN-γ responses peaked at 8–15 weeks and were higher in mildly affected animals than in those with severe lesions. |
| format | Article |
| id | doaj-art-1b2ca9b87d5e4d59aba2fccbd7c879ac |
| institution | OA Journals |
| issn | 2090-8113 2042-0048 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-1b2ca9b87d5e4d59aba2fccbd7c879ac2025-08-20T02:02:21ZengWileyVeterinary Medicine International2090-81132042-00482012-01-01201210.1155/2012/931948931948Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP)Colin Mackintosh0Gary Clark1Brendan Tolentino2Simon Liggett3Geoff de Lisle4Frank Griffin5AgResearch Invermay, P.O. Box 50034, Mosgiel, New Zealand14 Rimu Lane, Wanaka 9305, New ZealandAgResearch Invermay, P.O. Box 50034, Mosgiel, New ZealandDisease Research Laboratory, University of Otago, P.O. Box 56, Dunedin, New ZealandAgResearch Wallaceville, P.O. Box 40063, Upper Hutt, New ZealandDisease Research Laboratory, University of Otago, P.O. Box 56, Dunedin, New ZealandParatuberculosis progresses more quickly in young red deer than in sheep or cattle. This study describes the clinical, immunological and pathological changes over a 50-week period in fourteen 4-month-old red deer that received heavy oral challenge with Mycobacterium avium subsp. paratuberculosis (MAP). At 4 and 12 weeks post challenge they were anaesthetized and a section of jejunal lymph node was surgically removed for culture, histopathology, and genetic studies. All 14 deer became infected, none were clinically affected, and they had varying degrees of subclinical disease when killed at week 50. Week 4 biopsies showed no paratuberculosis lesions, but MAP was cultured from all animals. At weeks 12 and 50 histopathological lesions ranged from mild to severe with corresponding low-to-high antibody titres, which peaked at 12–24 weeks. IFN-γ responses peaked at 8–15 weeks and were higher in mildly affected animals than in those with severe lesions.http://dx.doi.org/10.1155/2012/931948 |
| spellingShingle | Colin Mackintosh Gary Clark Brendan Tolentino Simon Liggett Geoff de Lisle Frank Griffin Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP) Veterinary Medicine International |
| title | Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP) |
| title_full | Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP) |
| title_fullStr | Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP) |
| title_full_unstemmed | Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP) |
| title_short | Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP) |
| title_sort | longitudinal pathogenesis study of young red deer cervus elaphus after experimental challenge with mycobacterium avium subsp paratuberculosis map |
| url | http://dx.doi.org/10.1155/2012/931948 |
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