Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung Disease
Background. Although digital clubbing is a common presentation in patients with interstitial lung disease (ILD), little has been reported regarding its role in assessing patients with ILD. This study evaluated patients with ILD for the presence of clubbing and investigated its association with clini...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2018/3640967 |
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| author | Kazushige Shiraishi Torahiko Jinta Naoki Nishimura Hiroshi Nakaoka Ryosuke Tsugitomi Kohei Okafuji Atsushi Kitamura Yutaka Tomishima Gautam A. Deshpande Tomohide Tamura |
| author_facet | Kazushige Shiraishi Torahiko Jinta Naoki Nishimura Hiroshi Nakaoka Ryosuke Tsugitomi Kohei Okafuji Atsushi Kitamura Yutaka Tomishima Gautam A. Deshpande Tomohide Tamura |
| author_sort | Kazushige Shiraishi |
| collection | DOAJ |
| description | Background. Although digital clubbing is a common presentation in patients with interstitial lung disease (ILD), little has been reported regarding its role in assessing patients with ILD. This study evaluated patients with ILD for the presence of clubbing and investigated its association with clinical data. Methods. We evaluated patients with ILD who visited the teaching hospital at which the study was conducted, between October 2014 and January 2015. Clubbing, evaluated using a Vernier caliper for individual patients, was defined as a phalangeal depth ratio > 1. We examined the association of clubbing with clinical data. Results. Of 102 patients with ILD, we identified 17 (16.7%) with clubbing. The partial pressure of oxygen in arterial blood was lower (65.2 ± 5.9 mmHg versus 80.2 ± 3.1 mmHg; p=0.03), serum Krebs von den Lugen-6 (KL-6) levels were higher (1495.0 ± 277.4 U/mL versus 839.1 ± 70.2 U/mL; p=0.001), and the percent predicted diffusing capacity of carbon monoxide was lower (50.0 ± 6.0 versus 73.5 ± 3.1; p=0.002) in these patients with clubbing. Conclusions. Patients with clubbing had lower oxygen levels, higher serum KL-6 levels, and lower pulmonary function than those without clubbing. |
| format | Article |
| id | doaj-art-1b28c17ddd1f45a4b5605f1b986ca8ec |
| institution | OA Journals |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-1b28c17ddd1f45a4b5605f1b986ca8ec2025-08-20T02:02:21ZengWileyCanadian Respiratory Journal1198-22411916-72452018-01-01201810.1155/2018/36409673640967Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung DiseaseKazushige Shiraishi0Torahiko Jinta1Naoki Nishimura2Hiroshi Nakaoka3Ryosuke Tsugitomi4Kohei Okafuji5Atsushi Kitamura6Yutaka Tomishima7Gautam A. Deshpande8Tomohide Tamura9Department of Pulmonary Medicine, St. Luke’s International University, St. Luke’s International Hospital, Tokyo, JapanDepartment of Pulmonary Medicine, St. Luke’s International University, St. Luke’s International Hospital, Tokyo, JapanDepartment of Pulmonary Medicine, St. Luke’s International University, St. Luke’s International Hospital, Tokyo, JapanDepartment of Pulmonary Medicine, St. Luke’s International University, St. Luke’s International Hospital, Tokyo, JapanDepartment of Pulmonary Medicine, St. Luke’s International University, St. Luke’s International Hospital, Tokyo, JapanDepartment of Pulmonary Medicine, St. Luke’s International University, St. Luke’s International Hospital, Tokyo, JapanDepartment of Pulmonary Medicine, St. Luke’s International University, St. Luke’s International Hospital, Tokyo, JapanDepartment of Pulmonary Medicine, St. Luke’s International University, St. Luke’s International Hospital, Tokyo, JapanCenter for Clinical Epidemiology, St. Luke’s International University, St. Luke’s International Hospital, Tokyo, JapanDepartment of Pulmonary Medicine, St. Luke’s International University, St. Luke’s International Hospital, Tokyo, JapanBackground. Although digital clubbing is a common presentation in patients with interstitial lung disease (ILD), little has been reported regarding its role in assessing patients with ILD. This study evaluated patients with ILD for the presence of clubbing and investigated its association with clinical data. Methods. We evaluated patients with ILD who visited the teaching hospital at which the study was conducted, between October 2014 and January 2015. Clubbing, evaluated using a Vernier caliper for individual patients, was defined as a phalangeal depth ratio > 1. We examined the association of clubbing with clinical data. Results. Of 102 patients with ILD, we identified 17 (16.7%) with clubbing. The partial pressure of oxygen in arterial blood was lower (65.2 ± 5.9 mmHg versus 80.2 ± 3.1 mmHg; p=0.03), serum Krebs von den Lugen-6 (KL-6) levels were higher (1495.0 ± 277.4 U/mL versus 839.1 ± 70.2 U/mL; p=0.001), and the percent predicted diffusing capacity of carbon monoxide was lower (50.0 ± 6.0 versus 73.5 ± 3.1; p=0.002) in these patients with clubbing. Conclusions. Patients with clubbing had lower oxygen levels, higher serum KL-6 levels, and lower pulmonary function than those without clubbing.http://dx.doi.org/10.1155/2018/3640967 |
| spellingShingle | Kazushige Shiraishi Torahiko Jinta Naoki Nishimura Hiroshi Nakaoka Ryosuke Tsugitomi Kohei Okafuji Atsushi Kitamura Yutaka Tomishima Gautam A. Deshpande Tomohide Tamura Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung Disease Canadian Respiratory Journal |
| title | Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung Disease |
| title_full | Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung Disease |
| title_fullStr | Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung Disease |
| title_full_unstemmed | Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung Disease |
| title_short | Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung Disease |
| title_sort | digital clubbing is associated with higher serum kl 6 levels and lower pulmonary function in patients with interstitial lung disease |
| url | http://dx.doi.org/10.1155/2018/3640967 |
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