Exploring the virulence gene interactome with CRISPR/dCas9 in the human malaria parasite
Abstract Mutually exclusive expression of the var multigene family is key to immune evasion and pathogenesis in Plasmodium falciparum, but few factors have been shown to play a direct role. We adapted a CRISPR‐based proteomics approach to identify novel factors associated with var genes in their nat...
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| Main Authors: | Jessica M Bryant, Sebastian Baumgarten, Florent Dingli, Damarys Loew, Ameya Sinha, Aurélie Claës, Peter R Preiser, Peter C Dedon, Artur Scherf |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2020-08-01
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| Series: | Molecular Systems Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.15252/msb.20209569 |
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