Tinzaparin for the Management of Cancer Associated Thrombosis in Patients with Cancer: a Budget Impact Analysis from the Italian Healthcare System Perspective
BACKGROUND: Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is a significant health problem with especially increased prevalence, morbidity and mortality in patients with cancer. This study aimed at assessing the economic impact of tinzaparin in p...
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SEEd Medical Publishers
2025-06-01
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| Series: | Farmeconomia: Health Economics and Therapeutic Pathways |
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| Online Access: | https://journals.seedmedicalpublishers.com/index.php/FE/article/view/1566 |
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| author | Lorenzo Giovanni Mantovani Ippazio Cosimo Antonazzo Paolo Angelo Cortesi |
| author_facet | Lorenzo Giovanni Mantovani Ippazio Cosimo Antonazzo Paolo Angelo Cortesi |
| author_sort | Lorenzo Giovanni Mantovani |
| collection | DOAJ |
| description | BACKGROUND: Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is a significant health problem with especially increased prevalence, morbidity and mortality in patients with cancer. This study aimed at assessing the economic impact of tinzaparin in patients with cancer associated thrombosis (CAT).
METHODS: A budget impact model (BIM) was developed to assess the economic impact of tinzaparin as treatment for patients with CAT. The analysis was conducted over a 3-year time horizon and by adopting the Italian Healthcare system perspective. The model estimated and compared direct medical costs associated with tinzaparin (scenario with tinzaparin) to the ones associated without tinzaparin (scenario where only enoxaparin is available). Epidemiological data as well as VTE events’ rates were retrieved from literature, while costs data were retrieved from the Italian rate tables. The model estimated the economic impact as well as the economic variation associated with drug wastage and VTE management.
RESULTS: The model estimated 2,090, 4,202 and 5,429 patients potentially eligible to the treatment during the first, second and third year, respectively. The use of tinzaparin resulted in a cost saving of about €3 millions over 3 years (−€446,378 during the first, −€1,025,848 during the second, and −€1,657,508 during the third year). In the same timeframe, the use of tinzaparin also resulted in decreased costs associated with drug wastage (−€738,604) and recurrent VTE management (−€404,470).
CONCLUSIONS: Tinzaparin for the management of CAT patients has the potential for substantial savings, compared to treatments currently available. Stakeholders may consider these data to improve healthcare resource allocation in the Italian setting |
| format | Article |
| id | doaj-art-1b236f494ef44a0b9dc13f03bf1cd194 |
| institution | Kabale University |
| issn | 2240-256X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SEEd Medical Publishers |
| record_format | Article |
| series | Farmeconomia: Health Economics and Therapeutic Pathways |
| spelling | doaj-art-1b236f494ef44a0b9dc13f03bf1cd1942025-08-20T03:29:48ZengSEEd Medical PublishersFarmeconomia: Health Economics and Therapeutic Pathways2240-256X2025-06-0126110.7175/fe.v26i1.15661375Tinzaparin for the Management of Cancer Associated Thrombosis in Patients with Cancer: a Budget Impact Analysis from the Italian Healthcare System PerspectiveLorenzo Giovanni Mantovani0Ippazio Cosimo Antonazzo1Paolo Angelo Cortesi2Department of Medicine and Surgery, University of Milan-Bicocca, Monza, ItalyDepartment of Medicine and Surgery, University of Milan-Bicocca, Monza, ItalyDepartment of Medicine and Surgery, University of Milan-Bicocca, Monza, ItalyBACKGROUND: Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is a significant health problem with especially increased prevalence, morbidity and mortality in patients with cancer. This study aimed at assessing the economic impact of tinzaparin in patients with cancer associated thrombosis (CAT). METHODS: A budget impact model (BIM) was developed to assess the economic impact of tinzaparin as treatment for patients with CAT. The analysis was conducted over a 3-year time horizon and by adopting the Italian Healthcare system perspective. The model estimated and compared direct medical costs associated with tinzaparin (scenario with tinzaparin) to the ones associated without tinzaparin (scenario where only enoxaparin is available). Epidemiological data as well as VTE events’ rates were retrieved from literature, while costs data were retrieved from the Italian rate tables. The model estimated the economic impact as well as the economic variation associated with drug wastage and VTE management. RESULTS: The model estimated 2,090, 4,202 and 5,429 patients potentially eligible to the treatment during the first, second and third year, respectively. The use of tinzaparin resulted in a cost saving of about €3 millions over 3 years (−€446,378 during the first, −€1,025,848 during the second, and −€1,657,508 during the third year). In the same timeframe, the use of tinzaparin also resulted in decreased costs associated with drug wastage (−€738,604) and recurrent VTE management (−€404,470). CONCLUSIONS: Tinzaparin for the management of CAT patients has the potential for substantial savings, compared to treatments currently available. Stakeholders may consider these data to improve healthcare resource allocation in the Italian settinghttps://journals.seedmedicalpublishers.com/index.php/FE/article/view/1566thrombosiscancerlow molecular weight heparintinzaparinbudget impact analysis |
| spellingShingle | Lorenzo Giovanni Mantovani Ippazio Cosimo Antonazzo Paolo Angelo Cortesi Tinzaparin for the Management of Cancer Associated Thrombosis in Patients with Cancer: a Budget Impact Analysis from the Italian Healthcare System Perspective Farmeconomia: Health Economics and Therapeutic Pathways thrombosis cancer low molecular weight heparin tinzaparin budget impact analysis |
| title | Tinzaparin for the Management of Cancer Associated Thrombosis in Patients with Cancer: a Budget Impact Analysis from the Italian Healthcare System Perspective |
| title_full | Tinzaparin for the Management of Cancer Associated Thrombosis in Patients with Cancer: a Budget Impact Analysis from the Italian Healthcare System Perspective |
| title_fullStr | Tinzaparin for the Management of Cancer Associated Thrombosis in Patients with Cancer: a Budget Impact Analysis from the Italian Healthcare System Perspective |
| title_full_unstemmed | Tinzaparin for the Management of Cancer Associated Thrombosis in Patients with Cancer: a Budget Impact Analysis from the Italian Healthcare System Perspective |
| title_short | Tinzaparin for the Management of Cancer Associated Thrombosis in Patients with Cancer: a Budget Impact Analysis from the Italian Healthcare System Perspective |
| title_sort | tinzaparin for the management of cancer associated thrombosis in patients with cancer a budget impact analysis from the italian healthcare system perspective |
| topic | thrombosis cancer low molecular weight heparin tinzaparin budget impact analysis |
| url | https://journals.seedmedicalpublishers.com/index.php/FE/article/view/1566 |
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