The Precision-Guided Use of PI3K Pathway Inhibitors for the Treatment of Solid Malignancies

The Precision-Guided Use of PI3K Pathway Inhibitors for the Treatment of Solid Malignancies

Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (MTOR) pathway hyperactivation is seen in a multitude of malignancies. Due to the importance of this pathway in numerous critical cellular functions, preclinical and clinical investigations have aimed to target this pathway as an...

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Bibliographic Details
Main Authors: Alexa E. Schmitz, Shirsa Udgata, Katherine A. Johnson, Dustin A. Deming
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomedicines
Subjects:
PI3K
AKT
MTOR
targeted therapy
colorectal cancer
Online Access:https://www.mdpi.com/2227-9059/13/6/1319
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