Determinants of Functional Capacity and Quality of Life After Implantation of a Durable Left Ventricular Assist Device
Continuous-flow left ventricular assist devices (LVAD) are increasingly used as destination therapy in patients with end-stage heart failure and, with recent improvements in pump design, adverse event rates are decreasing. Implanted patients experience improved survival, quality of life (QoL) and fu...
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| Format: | Article |
| Language: | English |
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Radcliffe Medical Media
2020-10-01
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| Series: | Cardiac Failure Review |
| Online Access: | https://www.cfrjournal.com/articles/determinants-of-functional-capacity |
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| author | Kiran K Mirza Finn Gustafsson |
| author_facet | Kiran K Mirza Finn Gustafsson |
| author_sort | Kiran K Mirza |
| collection | DOAJ |
| description | Continuous-flow left ventricular assist devices (LVAD) are increasingly used as destination therapy in patients with end-stage heart failure and, with recent improvements in pump design, adverse event rates are decreasing. Implanted patients experience improved survival, quality of life (QoL) and functional capacity (FC). However, improvement in FC and QoL after implantation is not unequivocal, and this has implications for patient selection and preimplantation discussions with patients and relatives. This article identifies preimplantation predictors of lack of improvement in FC and QoL after continuous-flow LVAD implantation and discusses potential mechanisms, allowing for the identification of potential factors that can be modified. In particular, the pathophysiology behind insufficient improvement in peak oxygen uptake is discussed. Data are included from 40 studies, resulting in analysis of >700 exercise tests. Mean peak oxygen uptake was 13.4 ml/kg/min (equivalent to 48% of predicted value; 259 days after implantation, range 31–1,017 days) and mean 6-minute walk test distance was 370 m (182 days after implantation, range 43–543 days). Finally, the interplay between improvement in FC and QoL is discussed. |
| format | Article |
| id | doaj-art-1b08087001504db085ec2c909bcfc1e5 |
| institution | DOAJ |
| issn | 2057-7540 2057-7559 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | Cardiac Failure Review |
| spelling | doaj-art-1b08087001504db085ec2c909bcfc1e52025-08-20T02:39:22ZengRadcliffe Medical MediaCardiac Failure Review2057-75402057-75592020-10-01610.15420/cfr.2020.15Determinants of Functional Capacity and Quality of Life After Implantation of a Durable Left Ventricular Assist DeviceKiran K Mirza0Finn Gustafsson1Department of Cardiology, Rigshospitalet, Copenhagen, DenmarkDepartment of Cardiology, Rigshospitalet, Copenhagen, DenmarkContinuous-flow left ventricular assist devices (LVAD) are increasingly used as destination therapy in patients with end-stage heart failure and, with recent improvements in pump design, adverse event rates are decreasing. Implanted patients experience improved survival, quality of life (QoL) and functional capacity (FC). However, improvement in FC and QoL after implantation is not unequivocal, and this has implications for patient selection and preimplantation discussions with patients and relatives. This article identifies preimplantation predictors of lack of improvement in FC and QoL after continuous-flow LVAD implantation and discusses potential mechanisms, allowing for the identification of potential factors that can be modified. In particular, the pathophysiology behind insufficient improvement in peak oxygen uptake is discussed. Data are included from 40 studies, resulting in analysis of >700 exercise tests. Mean peak oxygen uptake was 13.4 ml/kg/min (equivalent to 48% of predicted value; 259 days after implantation, range 31–1,017 days) and mean 6-minute walk test distance was 370 m (182 days after implantation, range 43–543 days). Finally, the interplay between improvement in FC and QoL is discussed.https://www.cfrjournal.com/articles/determinants-of-functional-capacity |
| spellingShingle | Kiran K Mirza Finn Gustafsson Determinants of Functional Capacity and Quality of Life After Implantation of a Durable Left Ventricular Assist Device Cardiac Failure Review |
| title | Determinants of Functional Capacity and Quality of Life After Implantation of a Durable Left Ventricular Assist Device |
| title_full | Determinants of Functional Capacity and Quality of Life After Implantation of a Durable Left Ventricular Assist Device |
| title_fullStr | Determinants of Functional Capacity and Quality of Life After Implantation of a Durable Left Ventricular Assist Device |
| title_full_unstemmed | Determinants of Functional Capacity and Quality of Life After Implantation of a Durable Left Ventricular Assist Device |
| title_short | Determinants of Functional Capacity and Quality of Life After Implantation of a Durable Left Ventricular Assist Device |
| title_sort | determinants of functional capacity and quality of life after implantation of a durable left ventricular assist device |
| url | https://www.cfrjournal.com/articles/determinants-of-functional-capacity |
| work_keys_str_mv | AT kirankmirza determinantsoffunctionalcapacityandqualityoflifeafterimplantationofadurableleftventricularassistdevice AT finngustafsson determinantsoffunctionalcapacityandqualityoflifeafterimplantationofadurableleftventricularassistdevice |