Ergosterone-coupled Triazol molecules trigger mitochondrial dysfunction, oxidative stress, and acidocalcisomal Ca2+ release in Leishmania mexicana promastigotes

Ergosterone-coupled Triazol molecules trigger mitochondrial dysfunction, oxidative stress, and acidocalcisomal Ca2+ release in Leishmania mexicana promastigotes

The protozoan parasite Leishmania causes a variety of sicknesses with different clinical manifestations known as leishmaniasis. The chemotherapy currently in use is not adequate because of their side effects, resistance occurrence, and recurrences. Investigations looking for new targets or new activ...

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Bibliographic Details
Main Authors: Figarella K, Marsiccobetre S, Arocha I, Colina W, Hasegawa M, Rodriguez M, Rodriguez-Acosta A, Duszenko M, Benaim G, Uzcategui NL
Format: Article
Language:English
Published: Shared Science Publishers OG 2015-12-01
Series:Microbial Cell
Subjects:
Leishmania
ergosterol
azoles
cell death
autophagy
ROS
Ca2+
Online Access:http://microbialcell.com/researcharticles/ergosterone-coupled-triazol-molecules-trigger-mitochondrial-dysfunction-oxidative-stress-and-acidocalcisomal-ca2-release-in-leishmania-mexicana-promastigotes/
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