PlTem1, a Key Cell Cycle Regulator, Serves as an Important Bridge Between Cell Division and Autophagy in <i>Peronophythora litchii</i>
The orderly progression of the cell division process is crucial for the morphogenesis of pathogens and the process of infecting hosts. However, there is currently no relevant research on cell division in the pathogen <i>Peronophythora litchii</i>. First, we verified that treatment with c...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
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| Series: | Agronomy |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4395/15/7/1619 |
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| Summary: | The orderly progression of the cell division process is crucial for the morphogenesis of pathogens and the process of infecting hosts. However, there is currently no relevant research on cell division in the pathogen <i>Peronophythora litchii</i>. First, we verified that treatment with cell division inhibitors would have an adverse effect on the growth, development, and pathogenicity of <i>P. litchii</i>. Subsequently, through homology-based sequence alignment and functional domain prediction analyses, we identified PlTem1, a key small GTPase regulating cell division. Compared with the wild-type strain Shs3, the mutant strain Δ<i>Pltem1</i> exhibited significant defects in mycelial growth, sporangia and zoospore generation, and virulence. To explore the pathogenic mechanism of PlTem1, screening and identification of interacting proteins were carried out. The comprehensive results show that there is an interaction between Tem1 and multiple autophagy-related proteins, suggesting that PlTem1 serves as an important bridge between autophagy and cell division in <i>P. litchii</i>. |
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| ISSN: | 2073-4395 |