Application of Calcium Aluminate-Based Materials for Direct Pulp Capping – In Vivo Study
The aim of this paper is the histopathological assessment of the effects of a newly synthesized nanomaterial based on calcium aluminate ALBO-CA on the pulp of rat teeth. In 18 Wistar rats, 54 Class I cavities and exposed pulp of maxillary molars were treated with the tested materials: two experiment...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2025-06-01
|
| Series: | Acta Veterinaria |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acve-2025-0017 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850113257114697728 |
|---|---|
| author | Janković Ognjenka Paraš Smiljana Adamović Tijana Latinović Ljiljana Tadić Arbutina Radmila Đukić Igor Marin Saša Bulajić Marko Vukoje Karolina Jokanović Vukoman Pavlić Verica |
| author_facet | Janković Ognjenka Paraš Smiljana Adamović Tijana Latinović Ljiljana Tadić Arbutina Radmila Đukić Igor Marin Saša Bulajić Marko Vukoje Karolina Jokanović Vukoman Pavlić Verica |
| author_sort | Janković Ognjenka |
| collection | DOAJ |
| description | The aim of this paper is the histopathological assessment of the effects of a newly synthesized nanomaterial based on calcium aluminate ALBO-CA on the pulp of rat teeth. In 18 Wistar rats, 54 Class I cavities and exposed pulp of maxillary molars were treated with the tested materials: two experimental materials ALBO-CA (18 teeth), ALBO-CS (18 teeth), and MTA control (18 teeth), and cavities were restored with glass ionomer. The histopathological analysis included the following parameters: presence of pulp inflammation, degree of dentin bridge formation, and presence of bacteria in the pulp. Complete absence of pulp inflammation was noted in 12 (66.67 %) teeth with ALBO-CA, 10 (55.56 %) teeth with ALBO-CS, and 11 (60.95 %) teeth with MTA cement. A statistically significant difference in the results of pulp inflammatory response was found only when comparing the presence of a small number of polymorphonuclear leukocytes between ALBO-CS and MTA cement (Kruskal Wallis H test p=7.8255). A fully formed dentine bridge was recorded only after the application of ALBO-CA with a statistically significant difference compared to ALBO-CS and MTA (F test p=0.519, S-test p=0.656, Man-Whitney test p=2.802, Chi-square test p=4.747). Thirty days after the direct pulp capping with ALBO-CA, ALBO-CS, and MTA cements, bacteria were absent in rat teeth and surrounding tissue. Newly synthesized calcium aluminate ALBOCA showed good reparative abilities and possible use in direct pulp capping therapy. |
| format | Article |
| id | doaj-art-1afa220d4b664e49a1216e31b45eb86c |
| institution | OA Journals |
| issn | 1820-7448 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Veterinaria |
| spelling | doaj-art-1afa220d4b664e49a1216e31b45eb86c2025-08-20T02:37:13ZengSciendoActa Veterinaria1820-74482025-06-0175221223010.2478/acve-2025-0017Application of Calcium Aluminate-Based Materials for Direct Pulp Capping – In Vivo StudyJanković Ognjenka0Paraš Smiljana1Adamović Tijana2Latinović Ljiljana Tadić3Arbutina Radmila4Đukić Igor5Marin Saša6Bulajić Marko7Vukoje Karolina8Jokanović Vukoman9Pavlić Verica101University of Banja Luka, Faculty of Medicine, Department of Dental Diseases and Endodontics, the Republic of Srpska, Bosnia and Herzegovina2University of Banja Luka, Faculty of Science and Mathematics, Department of Cell Biology, Bosnia and Herzegovina3University of Banja Luka, Faculty of Medicine, Department of Periodontology and Oral Medicine, the Republic of Srpska, Bosnia and Herzegovina4Clinical Center, Institute of Pathology, Banja Luka, Bosnia and Herzegovina1University of Banja Luka, Faculty of Medicine, Department of Dental Diseases and Endodontics, the Republic of Srpska, Bosnia and Herzegovina5University of Banja Luka, Faculty of Medicine, Department of Oral Surgery, the Republic of Srpska, Bosnia and Herzegovina5University of Banja Luka, Faculty of Medicine, Department of Oral Surgery, the Republic of Srpska, Bosnia and Herzegovina5University of Banja Luka, Faculty of Medicine, Department of Oral Surgery, the Republic of Srpska, Bosnia and Herzegovina6University of Novi Sad, Faculty of Medicine, Department of Dentistry, Novi Sad, Serbia7Institute of Nuclear Sciences “Vinča”, Belgrade, Serbia.3University of Banja Luka, Faculty of Medicine, Department of Periodontology and Oral Medicine, the Republic of Srpska, Bosnia and HerzegovinaThe aim of this paper is the histopathological assessment of the effects of a newly synthesized nanomaterial based on calcium aluminate ALBO-CA on the pulp of rat teeth. In 18 Wistar rats, 54 Class I cavities and exposed pulp of maxillary molars were treated with the tested materials: two experimental materials ALBO-CA (18 teeth), ALBO-CS (18 teeth), and MTA control (18 teeth), and cavities were restored with glass ionomer. The histopathological analysis included the following parameters: presence of pulp inflammation, degree of dentin bridge formation, and presence of bacteria in the pulp. Complete absence of pulp inflammation was noted in 12 (66.67 %) teeth with ALBO-CA, 10 (55.56 %) teeth with ALBO-CS, and 11 (60.95 %) teeth with MTA cement. A statistically significant difference in the results of pulp inflammatory response was found only when comparing the presence of a small number of polymorphonuclear leukocytes between ALBO-CS and MTA cement (Kruskal Wallis H test p=7.8255). A fully formed dentine bridge was recorded only after the application of ALBO-CA with a statistically significant difference compared to ALBO-CS and MTA (F test p=0.519, S-test p=0.656, Man-Whitney test p=2.802, Chi-square test p=4.747). Thirty days after the direct pulp capping with ALBO-CA, ALBO-CS, and MTA cements, bacteria were absent in rat teeth and surrounding tissue. Newly synthesized calcium aluminate ALBOCA showed good reparative abilities and possible use in direct pulp capping therapy.https://doi.org/10.2478/acve-2025-0017calcium aluminatescalcium silicatesdirect pulp cappingnanomaterials |
| spellingShingle | Janković Ognjenka Paraš Smiljana Adamović Tijana Latinović Ljiljana Tadić Arbutina Radmila Đukić Igor Marin Saša Bulajić Marko Vukoje Karolina Jokanović Vukoman Pavlić Verica Application of Calcium Aluminate-Based Materials for Direct Pulp Capping – In Vivo Study Acta Veterinaria calcium aluminates calcium silicates direct pulp capping nanomaterials |
| title | Application of Calcium Aluminate-Based Materials for Direct Pulp Capping – In Vivo Study |
| title_full | Application of Calcium Aluminate-Based Materials for Direct Pulp Capping – In Vivo Study |
| title_fullStr | Application of Calcium Aluminate-Based Materials for Direct Pulp Capping – In Vivo Study |
| title_full_unstemmed | Application of Calcium Aluminate-Based Materials for Direct Pulp Capping – In Vivo Study |
| title_short | Application of Calcium Aluminate-Based Materials for Direct Pulp Capping – In Vivo Study |
| title_sort | application of calcium aluminate based materials for direct pulp capping in vivo study |
| topic | calcium aluminates calcium silicates direct pulp capping nanomaterials |
| url | https://doi.org/10.2478/acve-2025-0017 |
| work_keys_str_mv | AT jankovicognjenka applicationofcalciumaluminatebasedmaterialsfordirectpulpcappinginvivostudy AT parassmiljana applicationofcalciumaluminatebasedmaterialsfordirectpulpcappinginvivostudy AT adamovictijana applicationofcalciumaluminatebasedmaterialsfordirectpulpcappinginvivostudy AT latinovicljiljanatadic applicationofcalciumaluminatebasedmaterialsfordirectpulpcappinginvivostudy AT arbutinaradmila applicationofcalciumaluminatebasedmaterialsfordirectpulpcappinginvivostudy AT đukicigor applicationofcalciumaluminatebasedmaterialsfordirectpulpcappinginvivostudy AT marinsasa applicationofcalciumaluminatebasedmaterialsfordirectpulpcappinginvivostudy AT bulajicmarko applicationofcalciumaluminatebasedmaterialsfordirectpulpcappinginvivostudy AT vukojekarolina applicationofcalciumaluminatebasedmaterialsfordirectpulpcappinginvivostudy AT jokanovicvukoman applicationofcalciumaluminatebasedmaterialsfordirectpulpcappinginvivostudy AT pavlicverica applicationofcalciumaluminatebasedmaterialsfordirectpulpcappinginvivostudy |