The impact of atrial fibrillation type on clinical outcomes and antithrombotic therapy at discharge in patients with acute coronary syndrome or undergoing percutaneous coronary intervention: a real-world study
Abstract Background The type of atrial fibrillation (AF) is assumed as a vital factor in AF patients’ prognosis. However, its impact on clinical outcomes remains unclear in patients with AF complicated with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI). Methods...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-08-01
|
| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-025-05042-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849767521164460032 |
|---|---|
| author | Yimeng Wang Jingyang Wang Yuyuan Shu Yijing Xin Yanmin Yang |
| author_facet | Yimeng Wang Jingyang Wang Yuyuan Shu Yijing Xin Yanmin Yang |
| author_sort | Yimeng Wang |
| collection | DOAJ |
| description | Abstract Background The type of atrial fibrillation (AF) is assumed as a vital factor in AF patients’ prognosis. However, its impact on clinical outcomes remains unclear in patients with AF complicated with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI). Methods This study was a prospective, observational, single center study of adults with AF and ACS/PCI. The primary endpoint was major adverse cardiovascular events (MACE), and secondary endpoint was net adverse clinical outcome events (NACE), a composite of MACE events and major bleeding events. Results A total of 1,762 participants were enrolled in this study, 1,137 of them were paroxysmal AF and 625 were non- paroxysmal AF, with a median follow up time of 1,023 days. The mean age of this population was 67 ± 10 and 27.2% were female. Kaplan–Meier curves showed patients were under a higher incidence of both MACE (p < 0.001) and NACE (p < 0.001) in patients with non-paroxysmal AF. Multivariate Cox analysis showed that patients with non-paroxysmal AF had a higher risk of MACE (HR: 1.322; 95%CI 1.074–1.626) and NACE (HR: 1.341; 95%CI 1.095–1.644) compared to those with paroxysmal AF. Conclusions Our study demonstrated that among patients with ACS/PCI, those with non-paroxysmal AF were more likely to experience MACE and NACE. |
| format | Article |
| id | doaj-art-1af34cdcefaf4a9d98d74a3bd2faecad |
| institution | DOAJ |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-1af34cdcefaf4a9d98d74a3bd2faecad2025-08-20T03:04:10ZengBMCBMC Cardiovascular Disorders1471-22612025-08-012511810.1186/s12872-025-05042-7The impact of atrial fibrillation type on clinical outcomes and antithrombotic therapy at discharge in patients with acute coronary syndrome or undergoing percutaneous coronary intervention: a real-world studyYimeng Wang0Jingyang Wang1Yuyuan Shu2Yijing Xin3Yanmin Yang4Emergency and Intensive Care Center, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeEmergency and Intensive Care Center, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeEmergency and Intensive Care Center, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeEmergency and Intensive Care Center, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeEmergency and Intensive Care Center, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Background The type of atrial fibrillation (AF) is assumed as a vital factor in AF patients’ prognosis. However, its impact on clinical outcomes remains unclear in patients with AF complicated with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI). Methods This study was a prospective, observational, single center study of adults with AF and ACS/PCI. The primary endpoint was major adverse cardiovascular events (MACE), and secondary endpoint was net adverse clinical outcome events (NACE), a composite of MACE events and major bleeding events. Results A total of 1,762 participants were enrolled in this study, 1,137 of them were paroxysmal AF and 625 were non- paroxysmal AF, with a median follow up time of 1,023 days. The mean age of this population was 67 ± 10 and 27.2% were female. Kaplan–Meier curves showed patients were under a higher incidence of both MACE (p < 0.001) and NACE (p < 0.001) in patients with non-paroxysmal AF. Multivariate Cox analysis showed that patients with non-paroxysmal AF had a higher risk of MACE (HR: 1.322; 95%CI 1.074–1.626) and NACE (HR: 1.341; 95%CI 1.095–1.644) compared to those with paroxysmal AF. Conclusions Our study demonstrated that among patients with ACS/PCI, those with non-paroxysmal AF were more likely to experience MACE and NACE.https://doi.org/10.1186/s12872-025-05042-7Atrial fibrillation typeAcute coronary syndromePercutaneous coronary interventionCardiovascular adverse events |
| spellingShingle | Yimeng Wang Jingyang Wang Yuyuan Shu Yijing Xin Yanmin Yang The impact of atrial fibrillation type on clinical outcomes and antithrombotic therapy at discharge in patients with acute coronary syndrome or undergoing percutaneous coronary intervention: a real-world study BMC Cardiovascular Disorders Atrial fibrillation type Acute coronary syndrome Percutaneous coronary intervention Cardiovascular adverse events |
| title | The impact of atrial fibrillation type on clinical outcomes and antithrombotic therapy at discharge in patients with acute coronary syndrome or undergoing percutaneous coronary intervention: a real-world study |
| title_full | The impact of atrial fibrillation type on clinical outcomes and antithrombotic therapy at discharge in patients with acute coronary syndrome or undergoing percutaneous coronary intervention: a real-world study |
| title_fullStr | The impact of atrial fibrillation type on clinical outcomes and antithrombotic therapy at discharge in patients with acute coronary syndrome or undergoing percutaneous coronary intervention: a real-world study |
| title_full_unstemmed | The impact of atrial fibrillation type on clinical outcomes and antithrombotic therapy at discharge in patients with acute coronary syndrome or undergoing percutaneous coronary intervention: a real-world study |
| title_short | The impact of atrial fibrillation type on clinical outcomes and antithrombotic therapy at discharge in patients with acute coronary syndrome or undergoing percutaneous coronary intervention: a real-world study |
| title_sort | impact of atrial fibrillation type on clinical outcomes and antithrombotic therapy at discharge in patients with acute coronary syndrome or undergoing percutaneous coronary intervention a real world study |
| topic | Atrial fibrillation type Acute coronary syndrome Percutaneous coronary intervention Cardiovascular adverse events |
| url | https://doi.org/10.1186/s12872-025-05042-7 |
| work_keys_str_mv | AT yimengwang theimpactofatrialfibrillationtypeonclinicaloutcomesandantithrombotictherapyatdischargeinpatientswithacutecoronarysyndromeorundergoingpercutaneouscoronaryinterventionarealworldstudy AT jingyangwang theimpactofatrialfibrillationtypeonclinicaloutcomesandantithrombotictherapyatdischargeinpatientswithacutecoronarysyndromeorundergoingpercutaneouscoronaryinterventionarealworldstudy AT yuyuanshu theimpactofatrialfibrillationtypeonclinicaloutcomesandantithrombotictherapyatdischargeinpatientswithacutecoronarysyndromeorundergoingpercutaneouscoronaryinterventionarealworldstudy AT yijingxin theimpactofatrialfibrillationtypeonclinicaloutcomesandantithrombotictherapyatdischargeinpatientswithacutecoronarysyndromeorundergoingpercutaneouscoronaryinterventionarealworldstudy AT yanminyang theimpactofatrialfibrillationtypeonclinicaloutcomesandantithrombotictherapyatdischargeinpatientswithacutecoronarysyndromeorundergoingpercutaneouscoronaryinterventionarealworldstudy AT yimengwang impactofatrialfibrillationtypeonclinicaloutcomesandantithrombotictherapyatdischargeinpatientswithacutecoronarysyndromeorundergoingpercutaneouscoronaryinterventionarealworldstudy AT jingyangwang impactofatrialfibrillationtypeonclinicaloutcomesandantithrombotictherapyatdischargeinpatientswithacutecoronarysyndromeorundergoingpercutaneouscoronaryinterventionarealworldstudy AT yuyuanshu impactofatrialfibrillationtypeonclinicaloutcomesandantithrombotictherapyatdischargeinpatientswithacutecoronarysyndromeorundergoingpercutaneouscoronaryinterventionarealworldstudy AT yijingxin impactofatrialfibrillationtypeonclinicaloutcomesandantithrombotictherapyatdischargeinpatientswithacutecoronarysyndromeorundergoingpercutaneouscoronaryinterventionarealworldstudy AT yanminyang impactofatrialfibrillationtypeonclinicaloutcomesandantithrombotictherapyatdischargeinpatientswithacutecoronarysyndromeorundergoingpercutaneouscoronaryinterventionarealworldstudy |