A dual-genotype IDH-mutant infiltrating glioma, a real oligoastrocytoma in cerebral hemisphere
Since the 5th edition of CNS WHO classification. the categorization of oligoastrocytoma has been discontinued. It is now understood that the majority of tumors previously identified as oligoastrocytomas can be reclassified into either astrocytomas or oligodendrogliomas based on molecular characteris...
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Elsevier
2025-06-01
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| Series: | IBRO Neuroscience Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242125000314 |
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| author | Jing Liu, PhD Fan Lin, PhD Yanhua Sun, MM Xia Liu, MM |
| author_facet | Jing Liu, PhD Fan Lin, PhD Yanhua Sun, MM Xia Liu, MM |
| author_sort | Jing Liu, PhD |
| collection | DOAJ |
| description | Since the 5th edition of CNS WHO classification. the categorization of oligoastrocytoma has been discontinued. It is now understood that the majority of tumors previously identified as oligoastrocytomas can be reclassified into either astrocytomas or oligodendrogliomas based on molecular characteristics. In this report, we present a rare case of true oligoastrocytoma characterized by the coexistence of two distinct cell types within a single tumor mass, as evidenced in imaging findings and histological examination. The left frontal infiltrating glioma displayed calcification, and histological analysis revealed two morphologically distinct regions corresponding to oligodendroglioma and astrocytoma. Immunohistochemical and molecular pathology analyses, including IDH1, ATRX, TP53 mutations, H3K27me3 status, Tert promoter mutations, and 1p/19q co-deletion, are consistent with oligodendroglioma and astrocytoma, respectively. Post-surgery, the patient opted against radiotherapy and chemotherapy and showed no signs of recurrence at a 4-month follow-up, but was subsequently lost to follow-up. This case prompts questions about the prognosis and potential grading criteria for true oligoastrocytoma. It underscores the need for further case studies to potentially re-establish it as a distinct tumor type in future CNS WHO classifications. |
| format | Article |
| id | doaj-art-1af34525c976463d8bffe415d6fc59bf |
| institution | OA Journals |
| issn | 2667-2421 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj-art-1af34525c976463d8bffe415d6fc59bf2025-08-20T02:06:19ZengElsevierIBRO Neuroscience Reports2667-24212025-06-011836636910.1016/j.ibneur.2025.02.013A dual-genotype IDH-mutant infiltrating glioma, a real oligoastrocytoma in cerebral hemisphereJing Liu, PhD0Fan Lin, PhD1Yanhua Sun, MM2Xia Liu, MM3Department of Pathology, Shenzhen Second People’s Hospital, Shenzhen University 1st Affiliated Hospital, Shenzhen 518035, ChinaDepartment of Radiology, Shenzhen Second People’s Hospital, Shenzhen University 1st Affiliated Hospital, Shenzhen 518035, ChinaDepartment of Pathology, Shenzhen Second People’s Hospital, Shenzhen University 1st Affiliated Hospital, Shenzhen 518035, ChinaDepartment of Pathology, Shenzhen Second People’s Hospital, Shenzhen University 1st Affiliated Hospital, Shenzhen 518035, China; Corresponding author.Since the 5th edition of CNS WHO classification. the categorization of oligoastrocytoma has been discontinued. It is now understood that the majority of tumors previously identified as oligoastrocytomas can be reclassified into either astrocytomas or oligodendrogliomas based on molecular characteristics. In this report, we present a rare case of true oligoastrocytoma characterized by the coexistence of two distinct cell types within a single tumor mass, as evidenced in imaging findings and histological examination. The left frontal infiltrating glioma displayed calcification, and histological analysis revealed two morphologically distinct regions corresponding to oligodendroglioma and astrocytoma. Immunohistochemical and molecular pathology analyses, including IDH1, ATRX, TP53 mutations, H3K27me3 status, Tert promoter mutations, and 1p/19q co-deletion, are consistent with oligodendroglioma and astrocytoma, respectively. Post-surgery, the patient opted against radiotherapy and chemotherapy and showed no signs of recurrence at a 4-month follow-up, but was subsequently lost to follow-up. This case prompts questions about the prognosis and potential grading criteria for true oligoastrocytoma. It underscores the need for further case studies to potentially re-establish it as a distinct tumor type in future CNS WHO classifications.http://www.sciencedirect.com/science/article/pii/S2667242125000314oligoastrocytomadual-genotypeIDH-mutant1p/19q |
| spellingShingle | Jing Liu, PhD Fan Lin, PhD Yanhua Sun, MM Xia Liu, MM A dual-genotype IDH-mutant infiltrating glioma, a real oligoastrocytoma in cerebral hemisphere IBRO Neuroscience Reports oligoastrocytoma dual-genotype IDH-mutant 1p/19q |
| title | A dual-genotype IDH-mutant infiltrating glioma, a real oligoastrocytoma in cerebral hemisphere |
| title_full | A dual-genotype IDH-mutant infiltrating glioma, a real oligoastrocytoma in cerebral hemisphere |
| title_fullStr | A dual-genotype IDH-mutant infiltrating glioma, a real oligoastrocytoma in cerebral hemisphere |
| title_full_unstemmed | A dual-genotype IDH-mutant infiltrating glioma, a real oligoastrocytoma in cerebral hemisphere |
| title_short | A dual-genotype IDH-mutant infiltrating glioma, a real oligoastrocytoma in cerebral hemisphere |
| title_sort | dual genotype idh mutant infiltrating glioma a real oligoastrocytoma in cerebral hemisphere |
| topic | oligoastrocytoma dual-genotype IDH-mutant 1p/19q |
| url | http://www.sciencedirect.com/science/article/pii/S2667242125000314 |
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