Hydroxychloroquine enhances efferocytosis and modulates inflammation via MerTK/Gas6 signaling in a pristane-induced lupus mouse model

Hydroxychloroquine enhances efferocytosis and modulates inflammation via MerTK/Gas6 signaling in a pristane-induced lupus mouse model

BackgroundHydroxychloroquine (HCQ) is a frontline treatment for autoimmune diseases, including rheumatoid arthritis, Sjogren’s syndrome, and systemic lupus erythematosus (SLE), due to its potent immunomodulatory properties. Efferocytosis, a crucial process for tissue homeostasis by transmitting immu...

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Main Authors: Shin-Yi Liu, Yung-Ju Yeh, Ting-Yin Xue, Fei-Hung Hsieh, Ya-Wun Wu, Meng-Zhen Wu, Wei-Jing Li, Jun-Chieh J. Tsay, Shu-Yao Tsai, Chung-Ming Huang, Hen-Hong Chang, Hui-Chen Chen, Chun-Ping Lin, Gregory J. Tsay
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
HCQ
efferocytosis
MERTK
inflammation
SLE
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1524315/full
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