Comprehensive in silico characterization of nonsynonymous SNPs in the human ezrin (EZR) gene and their role in disease pathogenesis

Comprehensive in silico characterization of nonsynonymous SNPs in the human ezrin (EZR) gene and their role in disease pathogenesis

Ezrin (EZR) is a crucial linker between the actin cytoskeleton and the plasma membrane. It interacts with proteins involved in cancer-related signaling pathways. To assess the impact of nonsynonymous single nucleotide polymorphisms (nsSNPs) on EZR structure and function, we employed bioinformatics t...

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Bibliographic Details
Main Authors: Sadia Akter, Mohtasim Fuad, Zimam Mahmud, Sonia Tamanna, Mohammad Sayem, Khalid Hasan Raj, Md. Zakir Hossain Howlader
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Biochemistry and Biophysics Reports
Subjects:
EZR gene
Nonsynonymous mutations
FERM domain
ERM binding protein 50
Ezrin binding domain
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580825000597
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