Associations of vascular endothelial growth factor (VEGF) gene and cytokine (IL-1B, IL-4, IL-6, IL-10, TNFA) genes combinations with type 2 diabetes mellitus in women
Aim. To study the association between vascular endothelial growth factor (VEGF) and cytokine (IL1B, IL4, IL6, IL10 and TNFA)gene polymorphism combinations with type 2 diabetes mellitus (T2DM) in women. Materials and methods. 374 Caucasian women without carbohydrate metabolism disorders from 23 to...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2012-09-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/6079 |
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| author | Vladimir Iosifovich Konenkov Alla Vladimirovna Shevchenko Victor Fedorovich Prokof'ev Vadim Valer'evich Klimontov Maksim Alexandrovich Korolev Olga Nikolaevna Fazullina Svetlana Alexandrovna Lapsina Elena Anatol'evna Koroleva |
| author_facet | Vladimir Iosifovich Konenkov Alla Vladimirovna Shevchenko Victor Fedorovich Prokof'ev Vadim Valer'evich Klimontov Maksim Alexandrovich Korolev Olga Nikolaevna Fazullina Svetlana Alexandrovna Lapsina Elena Anatol'evna Koroleva |
| author_sort | Vladimir Iosifovich Konenkov |
| collection | DOAJ |
| description | Aim. To study the association between vascular endothelial growth factor (VEGF) and cytokine (IL1B, IL4, IL6, IL10 and TNFA)gene polymorphism combinations with type 2 diabetes mellitus (T2DM) in women. Materials and methods. 374 Caucasian women without carbohydrate metabolism disorders from 23 to 68 years of age and 212 womenwith T2DM from 28 to 69 years of age were included in the study. The combinations of polymorphism А-2578С, С+936Т in VEGFgene with polymorphism in IL1B С-31Т, IL4 С-590Т, IL6 G-174C, IL10 A-592C and А-1082G, TNFA А-238G, A-308G and A-863Cwere studied. Results. Analysis revealed 52 combined genetic variations with different rate of occurrence between diabetic and control groups(р |
| format | Article |
| id | doaj-art-1ae1aad294bc47faa8e277502664a9a4 |
| institution | DOAJ |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2012-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-1ae1aad294bc47faa8e277502664a9a42025-08-20T03:09:04ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782012-09-0115341010.14341/2072-0351-60796037Associations of vascular endothelial growth factor (VEGF) gene and cytokine (IL-1B, IL-4, IL-6, IL-10, TNFA) genes combinations with type 2 diabetes mellitus in womenVladimir Iosifovich Konenkov0Alla Vladimirovna Shevchenko1Victor Fedorovich Prokof'ev2Vadim Valer'evich Klimontov3Maksim Alexandrovich Korolev4Olga Nikolaevna Fazullina5Svetlana Alexandrovna Lapsina6Elena Anatol'evna Koroleva7Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russian FederationResearch Institute of Clinical and Experimental Lymphology, Novosibirsk, Russian FederationResearch Institute of Clinical and Experimental Lymphology, Novosibirsk, Russian FederationResearch Institute of Clinical and Experimental Lymphology, Novosibirsk, Russian FederationResearch Institute of Clinical and Experimental Lymphology, Novosibirsk, Russian FederationResearch Institute of Clinical and Experimental Lymphology, Novosibirsk, Russian FederationResearch Institute of Clinical and Experimental Lymphology, Novosibirsk, Russian FederationResearch Institute of Clinical and Experimental Lymphology, Novosibirsk, Russian FederationAim. To study the association between vascular endothelial growth factor (VEGF) and cytokine (IL1B, IL4, IL6, IL10 and TNFA)gene polymorphism combinations with type 2 diabetes mellitus (T2DM) in women. Materials and methods. 374 Caucasian women without carbohydrate metabolism disorders from 23 to 68 years of age and 212 womenwith T2DM from 28 to 69 years of age were included in the study. The combinations of polymorphism А-2578С, С+936Т in VEGFgene with polymorphism in IL1B С-31Т, IL4 С-590Т, IL6 G-174C, IL10 A-592C and А-1082G, TNFA А-238G, A-308G and A-863Cwere studied. Results. Analysis revealed 52 combined genetic variations with different rate of occurrence between diabetic and control groups(рhttps://www.dia-endojournals.ru/jour/article/view/6079type 2 diabetes mellitusgene polymorphismgrowth factorscytokines |
| spellingShingle | Vladimir Iosifovich Konenkov Alla Vladimirovna Shevchenko Victor Fedorovich Prokof'ev Vadim Valer'evich Klimontov Maksim Alexandrovich Korolev Olga Nikolaevna Fazullina Svetlana Alexandrovna Lapsina Elena Anatol'evna Koroleva Associations of vascular endothelial growth factor (VEGF) gene and cytokine (IL-1B, IL-4, IL-6, IL-10, TNFA) genes combinations with type 2 diabetes mellitus in women Сахарный диабет type 2 diabetes mellitus gene polymorphism growth factors cytokines |
| title | Associations of vascular endothelial growth factor (VEGF) gene and cytokine (IL-1B, IL-4, IL-6, IL-10, TNFA) genes combinations with type 2 diabetes mellitus in women |
| title_full | Associations of vascular endothelial growth factor (VEGF) gene and cytokine (IL-1B, IL-4, IL-6, IL-10, TNFA) genes combinations with type 2 diabetes mellitus in women |
| title_fullStr | Associations of vascular endothelial growth factor (VEGF) gene and cytokine (IL-1B, IL-4, IL-6, IL-10, TNFA) genes combinations with type 2 diabetes mellitus in women |
| title_full_unstemmed | Associations of vascular endothelial growth factor (VEGF) gene and cytokine (IL-1B, IL-4, IL-6, IL-10, TNFA) genes combinations with type 2 diabetes mellitus in women |
| title_short | Associations of vascular endothelial growth factor (VEGF) gene and cytokine (IL-1B, IL-4, IL-6, IL-10, TNFA) genes combinations with type 2 diabetes mellitus in women |
| title_sort | associations of vascular endothelial growth factor vegf gene and cytokine il 1b il 4 il 6 il 10 tnfa genes combinations with type 2 diabetes mellitus in women |
| topic | type 2 diabetes mellitus gene polymorphism growth factors cytokines |
| url | https://www.dia-endojournals.ru/jour/article/view/6079 |
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