Taltirelin induces TH expression by regulating TRHR and RARα in medium spiny neurons

Taltirelin induces TH expression by regulating TRHR and RARα in medium spiny neurons

Abstract Taltirelin, an orally effective thyrotropin-releasing hormone analog, significantly improves motor impairments in rat models of Parkinson's disease (PD) and enhances dopamine release within the striatum. However, the underlying mechanism remains unclear. In this study, a variety of in...

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Bibliographic Details
Main Authors: Kedong Zhu, Lanxia Meng, Jiaying Luo, Tingting Wen, Liang Dan, Zhihao Wang, Xuebing Cao, Zhaohui Zhang, Guiqin Chen
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Translational Medicine
Subjects:
Taltirelin
Dopamine receptor D2
Tyrosine hydroxylase
Thyrotropin-releasing hormone receptor
Online Access:https://doi.org/10.1186/s12967-024-06020-x
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