A Comprehensive Systematic Review and Meta-Analysis to Unravel the Noise-Dementia Nexus

ObjectivesAs the aging population grows, Alzheimer’s disease and related dementias (ADRD) present a major public health challenge. Environmental noise, linked to stress and sleep disruption, may increase ADRD risk. We aimed to summarize the research literature on long-term noise exposure and ADRD.Me...

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Main Authors: Soonmyung A. Hwang, Aditi Singhvi, Lokesh Patil, Kimiya Gohari, Maayan Yitshak Sade, Elena Colicino, Melissa D. Aldridge, Andrea A. Baccarelli, Itai Kloog, Joel Schwartz, R. Sean Morrison, Robert O. Wright, Henrik Bøggild, Ali Sheidaei, Pablo Knobel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Public Health Reviews
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Online Access:https://www.ssph-journal.org/articles/10.3389/phrs.2025.1607355/full
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author Soonmyung A. Hwang
Aditi Singhvi
Lokesh Patil
Kimiya Gohari
Maayan Yitshak Sade
Elena Colicino
Melissa D. Aldridge
Andrea A. Baccarelli
Itai Kloog
Itai Kloog
Joel Schwartz
R. Sean Morrison
R. Sean Morrison
Robert O. Wright
Robert O. Wright
Henrik Bøggild
Ali Sheidaei
Ali Sheidaei
Pablo Knobel
author_facet Soonmyung A. Hwang
Aditi Singhvi
Lokesh Patil
Kimiya Gohari
Maayan Yitshak Sade
Elena Colicino
Melissa D. Aldridge
Andrea A. Baccarelli
Itai Kloog
Itai Kloog
Joel Schwartz
R. Sean Morrison
R. Sean Morrison
Robert O. Wright
Robert O. Wright
Henrik Bøggild
Ali Sheidaei
Ali Sheidaei
Pablo Knobel
author_sort Soonmyung A. Hwang
collection DOAJ
description ObjectivesAs the aging population grows, Alzheimer’s disease and related dementias (ADRD) present a major public health challenge. Environmental noise, linked to stress and sleep disruption, may increase ADRD risk. We aimed to summarize the research literature on long-term noise exposure and ADRD.MethodsWe conducted a systematic review and meta-analysis of studies investigating the association of long-term (≥1 year) noise exposure and ADRD assessed with standardized diagnostic criteria. Two reviewers independently screened studies, extracted data, and assessed risk of bias. Eligible studies reported hazard ratios (HR) or similar effect estimates with confidence intervals.ResultsA multilevel random-effects meta-analysis of six longitudinal studies using 13 effect sizes found a significant association between long-term noise exposure and incident ADRD (HR: 1.15, 95% CI: 1.03–1.28). Interaction effects between noise source and dementia subtype were not statistically significant.ConclusionLong-term noise exposure may contribute to ADRD risk. Heterogeneity between studies highlights the need for standardized exposure assessment and consideration of other environmental factors. Future research should include the exposome approach for identifying environmental drivers of dementia.
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spelling doaj-art-1acd291ac8d34084a9fb3d2e85a143d82025-08-20T03:38:55ZengFrontiers Media S.A.Public Health Reviews2107-69522025-06-014610.3389/phrs.2025.16073551607355A Comprehensive Systematic Review and Meta-Analysis to Unravel the Noise-Dementia NexusSoonmyung A. Hwang0Aditi Singhvi1Lokesh Patil2Kimiya Gohari3Maayan Yitshak Sade4Elena Colicino5Melissa D. Aldridge6Andrea A. Baccarelli7Itai Kloog8Itai Kloog9Joel Schwartz10R. Sean Morrison11R. Sean Morrison12Robert O. Wright13Robert O. Wright14Henrik Bøggild15Ali Sheidaei16Ali Sheidaei17Pablo Knobel18Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Obstetrics, Gynecology and Reproductive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, United StatesDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesBrookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesOffice of the Dean, Harvard T.H. Chan School of Public Health, Boston, MA, United StatesDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesInstitute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United StatesBrookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesJames J. Peters Veterans Affairs Medical Center, Bronx, NY, United StatesDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesInstitute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Health Science and Technology, Aalborg University, Aalborg, DenmarkDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States0Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, IranDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesObjectivesAs the aging population grows, Alzheimer’s disease and related dementias (ADRD) present a major public health challenge. Environmental noise, linked to stress and sleep disruption, may increase ADRD risk. We aimed to summarize the research literature on long-term noise exposure and ADRD.MethodsWe conducted a systematic review and meta-analysis of studies investigating the association of long-term (≥1 year) noise exposure and ADRD assessed with standardized diagnostic criteria. Two reviewers independently screened studies, extracted data, and assessed risk of bias. Eligible studies reported hazard ratios (HR) or similar effect estimates with confidence intervals.ResultsA multilevel random-effects meta-analysis of six longitudinal studies using 13 effect sizes found a significant association between long-term noise exposure and incident ADRD (HR: 1.15, 95% CI: 1.03–1.28). Interaction effects between noise source and dementia subtype were not statistically significant.ConclusionLong-term noise exposure may contribute to ADRD risk. Heterogeneity between studies highlights the need for standardized exposure assessment and consideration of other environmental factors. Future research should include the exposome approach for identifying environmental drivers of dementia.https://www.ssph-journal.org/articles/10.3389/phrs.2025.1607355/fullAlzheimer’s disease and related dementias (ADRD)air pollutionexposomenoisemeta-analysis
spellingShingle Soonmyung A. Hwang
Aditi Singhvi
Lokesh Patil
Kimiya Gohari
Maayan Yitshak Sade
Elena Colicino
Melissa D. Aldridge
Andrea A. Baccarelli
Itai Kloog
Itai Kloog
Joel Schwartz
R. Sean Morrison
R. Sean Morrison
Robert O. Wright
Robert O. Wright
Henrik Bøggild
Ali Sheidaei
Ali Sheidaei
Pablo Knobel
A Comprehensive Systematic Review and Meta-Analysis to Unravel the Noise-Dementia Nexus
Public Health Reviews
Alzheimer’s disease and related dementias (ADRD)
air pollution
exposome
noise
meta-analysis
title A Comprehensive Systematic Review and Meta-Analysis to Unravel the Noise-Dementia Nexus
title_full A Comprehensive Systematic Review and Meta-Analysis to Unravel the Noise-Dementia Nexus
title_fullStr A Comprehensive Systematic Review and Meta-Analysis to Unravel the Noise-Dementia Nexus
title_full_unstemmed A Comprehensive Systematic Review and Meta-Analysis to Unravel the Noise-Dementia Nexus
title_short A Comprehensive Systematic Review and Meta-Analysis to Unravel the Noise-Dementia Nexus
title_sort comprehensive systematic review and meta analysis to unravel the noise dementia nexus
topic Alzheimer’s disease and related dementias (ADRD)
air pollution
exposome
noise
meta-analysis
url https://www.ssph-journal.org/articles/10.3389/phrs.2025.1607355/full
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