A Comprehensive Systematic Review and Meta-Analysis to Unravel the Noise-Dementia Nexus

A Comprehensive Systematic Review and Meta-Analysis to Unravel the Noise-Dementia Nexus

ObjectivesAs the aging population grows, Alzheimer’s disease and related dementias (ADRD) present a major public health challenge. Environmental noise, linked to stress and sleep disruption, may increase ADRD risk. We aimed to summarize the research literature on long-term noise exposure and ADRD.Me...

Full description

Saved in:
Bibliographic Details
Main Authors: Soonmyung A. Hwang, Aditi Singhvi, Lokesh Patil, Kimiya Gohari, Maayan Yitshak Sade, Elena Colicino, Melissa D. Aldridge, Andrea A. Baccarelli, Itai Kloog, Joel Schwartz, R. Sean Morrison, Robert O. Wright, Henrik Bøggild, Ali Sheidaei, Pablo Knobel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Public Health Reviews
Subjects:
Alzheimer’s disease and related dementias (ADRD)
air pollution
exposome
noise
meta-analysis
Online Access:https://www.ssph-journal.org/articles/10.3389/phrs.2025.1607355/full
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ObjectivesAs the aging population grows, Alzheimer’s disease and related dementias (ADRD) present a major public health challenge. Environmental noise, linked to stress and sleep disruption, may increase ADRD risk. We aimed to summarize the research literature on long-term noise exposure and ADRD.MethodsWe conducted a systematic review and meta-analysis of studies investigating the association of long-term (≥1 year) noise exposure and ADRD assessed with standardized diagnostic criteria. Two reviewers independently screened studies, extracted data, and assessed risk of bias. Eligible studies reported hazard ratios (HR) or similar effect estimates with confidence intervals.ResultsA multilevel random-effects meta-analysis of six longitudinal studies using 13 effect sizes found a significant association between long-term noise exposure and incident ADRD (HR: 1.15, 95% CI: 1.03–1.28). Interaction effects between noise source and dementia subtype were not statistically significant.ConclusionLong-term noise exposure may contribute to ADRD risk. Heterogeneity between studies highlights the need for standardized exposure assessment and consideration of other environmental factors. Future research should include the exposome approach for identifying environmental drivers of dementia.
ISSN:2107-6952

Similar Items