The Performance of the American Thyroid Association (ATA) and American College of Radiology (ACR-TIRAD) Thyroid Nodule Risk-Stratification Systems in Determining High-Risk Nodules, and the Correlation of Site, Size, and Autoimmunity with High-Risk Features
Introduction: Neck ultrasonography (US) and fine-needle aspiration (FNA) biopsy are usually used to evaluate thyroid nodules. This study aimed to evaluate the performance of two popular thyroid imaging reporting systems in detecting thyroid malignancy and to evaluate the correlation between thyroid...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
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| Online Access: | https://journals.lww.com/10.4103/ijem.ijem_154_23 |
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| author | Ibrahim H. Hussein Mahmood T. Altemimi Haider A. Alidrisi Ammar M. Saeed Almomin Nassar T. Alibrahim Muqdam A. Hamza Husam J. Imran Ibrahim A. Zaboon Ali H. Alhamza Hussein A. Nwayyir Abbas A. Mansour |
| author_facet | Ibrahim H. Hussein Mahmood T. Altemimi Haider A. Alidrisi Ammar M. Saeed Almomin Nassar T. Alibrahim Muqdam A. Hamza Husam J. Imran Ibrahim A. Zaboon Ali H. Alhamza Hussein A. Nwayyir Abbas A. Mansour |
| author_sort | Ibrahim H. Hussein |
| collection | DOAJ |
| description | Introduction:
Neck ultrasonography (US) and fine-needle aspiration (FNA) biopsy are usually used to evaluate thyroid nodules. This study aimed to evaluate the performance of two popular thyroid imaging reporting systems in detecting thyroid malignancy and to evaluate the correlation between thyroid autoimmunity, nodule site, and size in the development of malignancy.
Methods:
This prospective study was conducted from January 2019 to July 2021 in Basrah, Iraq. The American Thyroid Association (ATA) and American College of Radiology-Thyroid Imaging Reporting and Data (ACR-TIRAD) systems were used to evaluate the malignant potential of 143 thyroid nodules in 131 patients.
Results:
The sensitivity and positive predictive value (PPV) of the ATA system for detecting malignancy were 96% and 20.8% for low-risk and 100% and 4.3% for high-risk nodules, respectively. ACR-TIRAD sensitivity and PPV were 84% and 22.1% for low-risk and 80% and 4.2% for high-risk nodules, respectively. The specificity and negative predictive value (NPV) of the ATA system for detecting malignancy were 11.6% and 92.3% for low-risk and 10.5% and 100% for high-risk nodules, respectively. The ACR-TIRAD specificity and NPV were 28% and 87.8% for low-risk and 26% and 96.9% for high-risk nodules, respectively. The strength of the correlation between FNA performed across different Bethesda categories and age, sex, nodule size, and positive thyroid peroxidase (TPO) antibodies were 0.25, 0.01, 0.22, and 0.4, respectively.
Conclusion:
Both systems are effective; however, adopting TI-RADS stratification results in fewer biopsies being performed for thyroid nodule assessment. Only sex was found to be significantly correlated with FNA performance in thyroid-nodule evaluation. |
| format | Article |
| id | doaj-art-1acd275e42314774b9c85cb9c3e49c16 |
| institution | Kabale University |
| issn | 2230-8210 2230-9500 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj-art-1acd275e42314774b9c85cb9c3e49c162025-01-09T12:23:48ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002024-12-0128662262810.4103/ijem.ijem_154_23The Performance of the American Thyroid Association (ATA) and American College of Radiology (ACR-TIRAD) Thyroid Nodule Risk-Stratification Systems in Determining High-Risk Nodules, and the Correlation of Site, Size, and Autoimmunity with High-Risk FeaturesIbrahim H. HusseinMahmood T. AltemimiHaider A. AlidrisiAmmar M. Saeed AlmominNassar T. AlibrahimMuqdam A. HamzaHusam J. ImranIbrahim A. ZaboonAli H. AlhamzaHussein A. NwayyirAbbas A. MansourIntroduction: Neck ultrasonography (US) and fine-needle aspiration (FNA) biopsy are usually used to evaluate thyroid nodules. This study aimed to evaluate the performance of two popular thyroid imaging reporting systems in detecting thyroid malignancy and to evaluate the correlation between thyroid autoimmunity, nodule site, and size in the development of malignancy. Methods: This prospective study was conducted from January 2019 to July 2021 in Basrah, Iraq. The American Thyroid Association (ATA) and American College of Radiology-Thyroid Imaging Reporting and Data (ACR-TIRAD) systems were used to evaluate the malignant potential of 143 thyroid nodules in 131 patients. Results: The sensitivity and positive predictive value (PPV) of the ATA system for detecting malignancy were 96% and 20.8% for low-risk and 100% and 4.3% for high-risk nodules, respectively. ACR-TIRAD sensitivity and PPV were 84% and 22.1% for low-risk and 80% and 4.2% for high-risk nodules, respectively. The specificity and negative predictive value (NPV) of the ATA system for detecting malignancy were 11.6% and 92.3% for low-risk and 10.5% and 100% for high-risk nodules, respectively. The ACR-TIRAD specificity and NPV were 28% and 87.8% for low-risk and 26% and 96.9% for high-risk nodules, respectively. The strength of the correlation between FNA performed across different Bethesda categories and age, sex, nodule size, and positive thyroid peroxidase (TPO) antibodies were 0.25, 0.01, 0.22, and 0.4, respectively. Conclusion: Both systems are effective; however, adopting TI-RADS stratification results in fewer biopsies being performed for thyroid nodule assessment. Only sex was found to be significantly correlated with FNA performance in thyroid-nodule evaluation.https://journals.lww.com/10.4103/ijem.ijem_154_23american college of radiology-thyroid imaging reporting and dataamerican thyroid associationfine-needle aspirationthyroid nodule |
| spellingShingle | Ibrahim H. Hussein Mahmood T. Altemimi Haider A. Alidrisi Ammar M. Saeed Almomin Nassar T. Alibrahim Muqdam A. Hamza Husam J. Imran Ibrahim A. Zaboon Ali H. Alhamza Hussein A. Nwayyir Abbas A. Mansour The Performance of the American Thyroid Association (ATA) and American College of Radiology (ACR-TIRAD) Thyroid Nodule Risk-Stratification Systems in Determining High-Risk Nodules, and the Correlation of Site, Size, and Autoimmunity with High-Risk Features Indian Journal of Endocrinology and Metabolism american college of radiology-thyroid imaging reporting and data american thyroid association fine-needle aspiration thyroid nodule |
| title | The Performance of the American Thyroid Association (ATA) and American College of Radiology (ACR-TIRAD) Thyroid Nodule Risk-Stratification Systems in Determining High-Risk Nodules, and the Correlation of Site, Size, and Autoimmunity with High-Risk Features |
| title_full | The Performance of the American Thyroid Association (ATA) and American College of Radiology (ACR-TIRAD) Thyroid Nodule Risk-Stratification Systems in Determining High-Risk Nodules, and the Correlation of Site, Size, and Autoimmunity with High-Risk Features |
| title_fullStr | The Performance of the American Thyroid Association (ATA) and American College of Radiology (ACR-TIRAD) Thyroid Nodule Risk-Stratification Systems in Determining High-Risk Nodules, and the Correlation of Site, Size, and Autoimmunity with High-Risk Features |
| title_full_unstemmed | The Performance of the American Thyroid Association (ATA) and American College of Radiology (ACR-TIRAD) Thyroid Nodule Risk-Stratification Systems in Determining High-Risk Nodules, and the Correlation of Site, Size, and Autoimmunity with High-Risk Features |
| title_short | The Performance of the American Thyroid Association (ATA) and American College of Radiology (ACR-TIRAD) Thyroid Nodule Risk-Stratification Systems in Determining High-Risk Nodules, and the Correlation of Site, Size, and Autoimmunity with High-Risk Features |
| title_sort | performance of the american thyroid association ata and american college of radiology acr tirad thyroid nodule risk stratification systems in determining high risk nodules and the correlation of site size and autoimmunity with high risk features |
| topic | american college of radiology-thyroid imaging reporting and data american thyroid association fine-needle aspiration thyroid nodule |
| url | https://journals.lww.com/10.4103/ijem.ijem_154_23 |
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