Does transient serum phosphate or serum phosphate status cause chronic kidney disease-associated pruritus in peritoneal dialysis patients? A cross-sectional and group-based trajectory modeling study
Background Chronic kidney disease-associated pruritus (CKD-aP) is a common complication in peritoneal dialysis (PD) patients. Whether serum phosphate is associated with CKD-aP is controversial. We identified the serum phosphate trajectories of PD patients in the last 3 months and investigated the ef...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2540557 |
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| author | Zijun Zhou Hanqing Zhang Yunze Xing Tao Zhang Yaxuan Fang Yueqi Zhang Hanqi Yang Junchen Li Yintao Zhang Bo Yang |
| author_facet | Zijun Zhou Hanqing Zhang Yunze Xing Tao Zhang Yaxuan Fang Yueqi Zhang Hanqi Yang Junchen Li Yintao Zhang Bo Yang |
| author_sort | Zijun Zhou |
| collection | DOAJ |
| description | Background Chronic kidney disease-associated pruritus (CKD-aP) is a common complication in peritoneal dialysis (PD) patients. Whether serum phosphate is associated with CKD-aP is controversial. We identified the serum phosphate trajectories of PD patients in the last 3 months and investigated the effects of serum phosphate persistence on CKD-aP.Methods A total of 407 PD patients from the PD Center of the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine were included. The 14-item UP-Dial was used to investigate the prevalence and clinical characteristics. PD patients were identified with different trajectories of serum phosphate by group-based trajectory modeling.Results The prevalence of CKD-aP in PD patients was 51.8%. Among 407 PD patients, four distinct serum phosphate trajectories were identified. Both transient serum phosphate and serum phosphate status were associated with CKD-aP. Transient serum phosphate was associated with an increased risk of CKD-aP [OR (95%CI): 2.28 (1.30–4.02), 2.24 (1.22–4.10), 3.04 (1.66–5.58), 2.12 (1.21–3.70), respectively]. Compared with the persistent low-level group, the gradual increase group was not associated with an increased risk of CKD-aP [OR (95%CI): 1.59 (0.77–3.26)]. Both the gradual decrease group and the persistent high-level group were positively associated with an increased risk of CKD-aP [OR (95%CI): 2.18 (1.30–3.66), 3.19 (1.60–6.36), respectively].Conclusion Our study confirmed the relationship between serum phosphate and CKD-aP within the past 3 months, to some extent explaining the controversy generated by previous studies. These results may help clinicians better understand the relationship between serum phosphate and CKD-aP and the importance of controlling serum phosphate. |
| format | Article |
| id | doaj-art-1acb975cf13f4e34bb00219253c8678f |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-1acb975cf13f4e34bb00219253c8678f2025-08-20T03:39:05ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2540557Does transient serum phosphate or serum phosphate status cause chronic kidney disease-associated pruritus in peritoneal dialysis patients? A cross-sectional and group-based trajectory modeling studyZijun Zhou0Hanqing Zhang1Yunze Xing2Tao Zhang3Yaxuan Fang4Yueqi Zhang5Hanqi Yang6Junchen Li7Yintao Zhang8Bo Yang9Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaBackground Chronic kidney disease-associated pruritus (CKD-aP) is a common complication in peritoneal dialysis (PD) patients. Whether serum phosphate is associated with CKD-aP is controversial. We identified the serum phosphate trajectories of PD patients in the last 3 months and investigated the effects of serum phosphate persistence on CKD-aP.Methods A total of 407 PD patients from the PD Center of the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine were included. The 14-item UP-Dial was used to investigate the prevalence and clinical characteristics. PD patients were identified with different trajectories of serum phosphate by group-based trajectory modeling.Results The prevalence of CKD-aP in PD patients was 51.8%. Among 407 PD patients, four distinct serum phosphate trajectories were identified. Both transient serum phosphate and serum phosphate status were associated with CKD-aP. Transient serum phosphate was associated with an increased risk of CKD-aP [OR (95%CI): 2.28 (1.30–4.02), 2.24 (1.22–4.10), 3.04 (1.66–5.58), 2.12 (1.21–3.70), respectively]. Compared with the persistent low-level group, the gradual increase group was not associated with an increased risk of CKD-aP [OR (95%CI): 1.59 (0.77–3.26)]. Both the gradual decrease group and the persistent high-level group were positively associated with an increased risk of CKD-aP [OR (95%CI): 2.18 (1.30–3.66), 3.19 (1.60–6.36), respectively].Conclusion Our study confirmed the relationship between serum phosphate and CKD-aP within the past 3 months, to some extent explaining the controversy generated by previous studies. These results may help clinicians better understand the relationship between serum phosphate and CKD-aP and the importance of controlling serum phosphate.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2540557Chronic kidney disease-associated pruritusgroup-based trajectory modelingperitoneal dialysispersistent serum phosphate statusphosphorus-lowering therapy |
| spellingShingle | Zijun Zhou Hanqing Zhang Yunze Xing Tao Zhang Yaxuan Fang Yueqi Zhang Hanqi Yang Junchen Li Yintao Zhang Bo Yang Does transient serum phosphate or serum phosphate status cause chronic kidney disease-associated pruritus in peritoneal dialysis patients? A cross-sectional and group-based trajectory modeling study Renal Failure Chronic kidney disease-associated pruritus group-based trajectory modeling peritoneal dialysis persistent serum phosphate status phosphorus-lowering therapy |
| title | Does transient serum phosphate or serum phosphate status cause chronic kidney disease-associated pruritus in peritoneal dialysis patients? A cross-sectional and group-based trajectory modeling study |
| title_full | Does transient serum phosphate or serum phosphate status cause chronic kidney disease-associated pruritus in peritoneal dialysis patients? A cross-sectional and group-based trajectory modeling study |
| title_fullStr | Does transient serum phosphate or serum phosphate status cause chronic kidney disease-associated pruritus in peritoneal dialysis patients? A cross-sectional and group-based trajectory modeling study |
| title_full_unstemmed | Does transient serum phosphate or serum phosphate status cause chronic kidney disease-associated pruritus in peritoneal dialysis patients? A cross-sectional and group-based trajectory modeling study |
| title_short | Does transient serum phosphate or serum phosphate status cause chronic kidney disease-associated pruritus in peritoneal dialysis patients? A cross-sectional and group-based trajectory modeling study |
| title_sort | does transient serum phosphate or serum phosphate status cause chronic kidney disease associated pruritus in peritoneal dialysis patients a cross sectional and group based trajectory modeling study |
| topic | Chronic kidney disease-associated pruritus group-based trajectory modeling peritoneal dialysis persistent serum phosphate status phosphorus-lowering therapy |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2540557 |
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