Sex-modulated association between thyroid stimulating hormone and informant-perceived anxiety in non-depressed older adults: Prediction models and relevant cutoff value
Abstract The aim of this study was to assess the association between thyroid function and perceived anxiety in non-depressed older adults. Non-depressed Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants with complete Thyroid Stimulating Hormone (TSH) and neuropsychiatric inventory (NPI...
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2025-01-01
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| author | Asma Hallab |
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| description | Abstract The aim of this study was to assess the association between thyroid function and perceived anxiety in non-depressed older adults. Non-depressed Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants with complete Thyroid Stimulating Hormone (TSH) and neuropsychiatric inventory (NPI/NPI-Q) were included. The association between anxiety and thyroid function was assessed by logistic regression and sex stratification. Restricted cubic splines were applied to evaluate non-linearity in the association. The median age of 2,114 eligible participants was 73 years (68–78), 1,117 (52.84%) were males, and the median TSH was 1.69 µIU/mL. There was a significant association between TSH and informant-perceived anxiety in the total study population (ORModel1 = 0.86, 95%CI 0.76–0.97, p = 0.011), even after adjusting for bio-demographical (adj.ORModel2 = 0.85, 95%CI 0.75–0.96, p = 0.007), and socio-cognitive confounders (adj.ORModel3 = 0.84, 95%CI 0.73–0.96, p = 0.009). Sex-stratification showed similar significant results in all male-specific models (ORModel1-male = 0.71, 95%CI: 0.58–0.85, p Model1-male < 0.001). In the general population and males, a TSH value of 2.4 µIU/dL was a significant cutoff under which anxiety odds were significantly high, even after adjusting for confounders. The sex-dependent association between TSH levels and perceived anxiety in non-depressed older adults is a novel finding that has to be further explored for a better understanding of the underlying neurobehavioral biology. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-1ac65287c8f84d19a9c663c4fe3c0c252025-01-26T12:28:22ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-025-86703-7Sex-modulated association between thyroid stimulating hormone and informant-perceived anxiety in non-depressed older adults: Prediction models and relevant cutoff valueAsma Hallab0Biologie Intégrative et Physiologie – Neurosciences Cellulaires et Intégrées, Faculté des Sciences et Ingénierie, Sorbonne UniversitéAbstract The aim of this study was to assess the association between thyroid function and perceived anxiety in non-depressed older adults. Non-depressed Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants with complete Thyroid Stimulating Hormone (TSH) and neuropsychiatric inventory (NPI/NPI-Q) were included. The association between anxiety and thyroid function was assessed by logistic regression and sex stratification. Restricted cubic splines were applied to evaluate non-linearity in the association. The median age of 2,114 eligible participants was 73 years (68–78), 1,117 (52.84%) were males, and the median TSH was 1.69 µIU/mL. There was a significant association between TSH and informant-perceived anxiety in the total study population (ORModel1 = 0.86, 95%CI 0.76–0.97, p = 0.011), even after adjusting for bio-demographical (adj.ORModel2 = 0.85, 95%CI 0.75–0.96, p = 0.007), and socio-cognitive confounders (adj.ORModel3 = 0.84, 95%CI 0.73–0.96, p = 0.009). Sex-stratification showed similar significant results in all male-specific models (ORModel1-male = 0.71, 95%CI: 0.58–0.85, p Model1-male < 0.001). In the general population and males, a TSH value of 2.4 µIU/dL was a significant cutoff under which anxiety odds were significantly high, even after adjusting for confounders. The sex-dependent association between TSH levels and perceived anxiety in non-depressed older adults is a novel finding that has to be further explored for a better understanding of the underlying neurobehavioral biology.https://doi.org/10.1038/s41598-025-86703-7ThyroidOlder adultsPredictive modelingStressHormonesPsychoneuroendocrinology |
| spellingShingle | Asma Hallab Sex-modulated association between thyroid stimulating hormone and informant-perceived anxiety in non-depressed older adults: Prediction models and relevant cutoff value Scientific Reports Thyroid Older adults Predictive modeling Stress Hormones Psychoneuroendocrinology |
| title | Sex-modulated association between thyroid stimulating hormone and informant-perceived anxiety in non-depressed older adults: Prediction models and relevant cutoff value |
| title_full | Sex-modulated association between thyroid stimulating hormone and informant-perceived anxiety in non-depressed older adults: Prediction models and relevant cutoff value |
| title_fullStr | Sex-modulated association between thyroid stimulating hormone and informant-perceived anxiety in non-depressed older adults: Prediction models and relevant cutoff value |
| title_full_unstemmed | Sex-modulated association between thyroid stimulating hormone and informant-perceived anxiety in non-depressed older adults: Prediction models and relevant cutoff value |
| title_short | Sex-modulated association between thyroid stimulating hormone and informant-perceived anxiety in non-depressed older adults: Prediction models and relevant cutoff value |
| title_sort | sex modulated association between thyroid stimulating hormone and informant perceived anxiety in non depressed older adults prediction models and relevant cutoff value |
| topic | Thyroid Older adults Predictive modeling Stress Hormones Psychoneuroendocrinology |
| url | https://doi.org/10.1038/s41598-025-86703-7 |
| work_keys_str_mv | AT asmahallab sexmodulatedassociationbetweenthyroidstimulatinghormoneandinformantperceivedanxietyinnondepressedolderadultspredictionmodelsandrelevantcutoffvalue |