The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders

The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders

Abstract Introduction The SPIN (Sant Pau Initiative on Neurodegeneration) cohort is a multimodal biomarker platform designed for neurodegenerative disease research following an integrative approach. Methods Participants of the SPIN cohort provide informed consent to donate blood and cerebrospinal fl...

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Main Authors: Daniel Alcolea, Jordi Clarimón, María Carmona‐Iragui, Ignacio Illán‐Gala, Estrella Morenas‐Rodríguez, Isabel Barroeta, Roser Ribosa‐Nogué, Isabel Sala, M. Belén Sánchez‐Saudinós, Laura Videla, Andrea Subirana, Bessy Benejam, Sílvia Valldeneu, Susana Fernández, Teresa Estellés, Miren Altuna, Miguel Santos‐Santos, Lídia García‐Losada, Alexandre Bejanin, Jordi Pegueroles, Víctor Montal, Eduard Vilaplana, Olivia Belbin, Oriol Dols‐Icardo, Sònia Sirisi, Marta Querol‐Vilaseca, Laura Cervera‐Carles, Laia Muñoz, Raúl Núñez, Soraya Torres, M. Valle Camacho, Ignasi Carrió, Sandra Giménez, Constance Delaby, Ricard Rojas‐Garcia, Janina Turon‐Sans, Javier Pagonabarraga, Amanda Jiménez, Rafael Blesa, Juan Fortea, Alberto Lleó
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Biomarkers
Neuroimaging
Alzheimer's disease
Frontontemporal dementia
Dementia with Lewy bodies
Neurodegeneration
Online Access:https://doi.org/10.1016/j.trci.2019.09.005
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Summary:Abstract Introduction The SPIN (Sant Pau Initiative on Neurodegeneration) cohort is a multimodal biomarker platform designed for neurodegenerative disease research following an integrative approach. Methods Participants of the SPIN cohort provide informed consent to donate blood and cerebrospinal fluid samples, receive detailed neurological and neuropsychological evaluations, and undergo a structural 3T brain MRI scan. A subset also undergoes other functional or imaging studies (video‐polysomnogram, 18F‐fluorodeoxyglucose PET, amyloid PET, Tau PET). Participants are followed annually for a minimum of 4 years, with repeated cerebrospinal fluid collection and imaging studies performed every other year, and brain donation is encouraged. Results The integration of clinical, neuropsychological, genetic, biochemical, imaging, and neuropathological information and the harmonization of protocols under the same umbrella allows the discovery and validation of key biomarkers across several neurodegenerative diseases. Discussion We describe our particular 10‐year experience and how different research projects were unified under an umbrella biomarker program, which might be of help to other research teams pursuing similar approaches.
ISSN:2352-8737

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