Prevalence of latent tuberculosis and mycobacterial infections in medicolegal cases with pleural adhesions: An observational study
Objective and Background: Pleural adhesions, fibrous bands between pleural layers, are common in autopsies and often associated with Tuberculosis (TB). This study aims to determine the prevalence of latent TB and mycobacterial infections in medicolegal cases with pleural adhesions. The focus is on v...
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Elsevier
2025-07-01
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| Series: | Forensic Science International: Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665910725000027 |
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| author | Jayanthi Yadav Ujjawal Khurana Shubham Richariya Shashank Purwar Sangita Moirangthem Johann Aibantyllilang Blah |
| author_facet | Jayanthi Yadav Ujjawal Khurana Shubham Richariya Shashank Purwar Sangita Moirangthem Johann Aibantyllilang Blah |
| author_sort | Jayanthi Yadav |
| collection | DOAJ |
| description | Objective and Background: Pleural adhesions, fibrous bands between pleural layers, are common in autopsies and often associated with Tuberculosis (TB). This study aims to determine the prevalence of latent TB and mycobacterial infections in medicolegal cases with pleural adhesions. The focus is on various diagnostic approaches and implications of the study for TB management in a high-burden setting like India. Materials and Methods: The observational study spanned two years, involving 743 autopsies at AIIMS Bhopal. Tissue samples from 82 cases with pleural adhesions were analyzed after obtaining consent and a detailed history. Diagnostic methods, including direct smear microscopy, Mycobacteria Growth Indicator (MGIT), Lowenstein–Jensen (LJ) media, and PCR, were employed. Observation: Of 164 cases with pleural adhesions, 15 (18.29 %) were positive for Mycobacterium, including 11 MTB and 4 NTM cases. Diagnostic methods revealed the challenges in detecting latent TB. Incidental diagnoses were prevalent, emphasizing the need for heightened awareness. Advanced techniques (MGIT, LJ, PCR) improved detection rates. The study highlights latent TB's impact in India, suggesting the importance of research, surveillance, and interventions for effective TB control. Addressing latent TB becomes crucial in global eradication efforts. Conclusion: The study emphasizes India's TB burden, with pleural adhesions acting as clinical markers. Incidental diagnoses and the role of latent TB in the population underscore the need for enhanced research and diagnostic strategies. Diagnostic challenges, including limited symptoms, necessitate advanced techniques. The study discusses the multifaceted challenge of latent TB diagnosis and the importance of interventions. |
| format | Article |
| id | doaj-art-1ab9a30e25884ec1b416cade40685b80 |
| institution | Kabale University |
| issn | 2665-9107 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Forensic Science International: Reports |
| spelling | doaj-art-1ab9a30e25884ec1b416cade40685b802025-01-24T04:45:40ZengElsevierForensic Science International: Reports2665-91072025-07-0111100406Prevalence of latent tuberculosis and mycobacterial infections in medicolegal cases with pleural adhesions: An observational studyJayanthi Yadav0Ujjawal Khurana1Shubham Richariya2Shashank Purwar3Sangita Moirangthem4Johann Aibantyllilang Blah5Department of forensic medicine & toxicology, All India Institute of Medical Sciences Bhopal, India; Correspondence to: Department of forensic medicine & toxicology, Sardar Vallabh Bhai Patel Bhawan, All India Institute of Medical Sciences Bhopal, Saket nagar, Bhopal, MP 462020, India.Department of Pathology & lab medicine, All India Institute of Medical Sciences Bhopal, IndiaDepartment of forensic medicine & toxicology, All India Institute of Medical Sciences Bhopal, IndiaDepartment of Microbiology, All India Institute of Medical Sciences Bhopal, IndiaDepartment of forensic medicine & toxicology, All India Institute of Medical Sciences Bhopal, IndiaDepartment of Community Medicine, All India Institute of Medical Sciences Jammu, IndiaObjective and Background: Pleural adhesions, fibrous bands between pleural layers, are common in autopsies and often associated with Tuberculosis (TB). This study aims to determine the prevalence of latent TB and mycobacterial infections in medicolegal cases with pleural adhesions. The focus is on various diagnostic approaches and implications of the study for TB management in a high-burden setting like India. Materials and Methods: The observational study spanned two years, involving 743 autopsies at AIIMS Bhopal. Tissue samples from 82 cases with pleural adhesions were analyzed after obtaining consent and a detailed history. Diagnostic methods, including direct smear microscopy, Mycobacteria Growth Indicator (MGIT), Lowenstein–Jensen (LJ) media, and PCR, were employed. Observation: Of 164 cases with pleural adhesions, 15 (18.29 %) were positive for Mycobacterium, including 11 MTB and 4 NTM cases. Diagnostic methods revealed the challenges in detecting latent TB. Incidental diagnoses were prevalent, emphasizing the need for heightened awareness. Advanced techniques (MGIT, LJ, PCR) improved detection rates. The study highlights latent TB's impact in India, suggesting the importance of research, surveillance, and interventions for effective TB control. Addressing latent TB becomes crucial in global eradication efforts. Conclusion: The study emphasizes India's TB burden, with pleural adhesions acting as clinical markers. Incidental diagnoses and the role of latent TB in the population underscore the need for enhanced research and diagnostic strategies. Diagnostic challenges, including limited symptoms, necessitate advanced techniques. The study discusses the multifaceted challenge of latent TB diagnosis and the importance of interventions.http://www.sciencedirect.com/science/article/pii/S2665910725000027Pleural adhesionForensic pathologyIncidental TuberculosisLatent tuberculosisNon tubercular mycobacteria |
| spellingShingle | Jayanthi Yadav Ujjawal Khurana Shubham Richariya Shashank Purwar Sangita Moirangthem Johann Aibantyllilang Blah Prevalence of latent tuberculosis and mycobacterial infections in medicolegal cases with pleural adhesions: An observational study Forensic Science International: Reports Pleural adhesion Forensic pathology Incidental Tuberculosis Latent tuberculosis Non tubercular mycobacteria |
| title | Prevalence of latent tuberculosis and mycobacterial infections in medicolegal cases with pleural adhesions: An observational study |
| title_full | Prevalence of latent tuberculosis and mycobacterial infections in medicolegal cases with pleural adhesions: An observational study |
| title_fullStr | Prevalence of latent tuberculosis and mycobacterial infections in medicolegal cases with pleural adhesions: An observational study |
| title_full_unstemmed | Prevalence of latent tuberculosis and mycobacterial infections in medicolegal cases with pleural adhesions: An observational study |
| title_short | Prevalence of latent tuberculosis and mycobacterial infections in medicolegal cases with pleural adhesions: An observational study |
| title_sort | prevalence of latent tuberculosis and mycobacterial infections in medicolegal cases with pleural adhesions an observational study |
| topic | Pleural adhesion Forensic pathology Incidental Tuberculosis Latent tuberculosis Non tubercular mycobacteria |
| url | http://www.sciencedirect.com/science/article/pii/S2665910725000027 |
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