Toxicological assessment and risk management of nanoparticles mediated composite materials-critical review: state of the art
Abstract Around the world, new composites, nanomaterial (NM) products, and tailored nanoparticles (NPs) are constantly being developed. Due to its many applications in the rapidly expanding field of nanotechnology, the manufacturing of nanoparticles is growing. NPs can efficiently migrate to the cir...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-06-01
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| Series: | Discover Polymers |
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| Online Access: | https://doi.org/10.1007/s44347-025-00023-7 |
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| _version_ | 1850109897801203712 |
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| author | Gaurav Pathak Swati Mangla Guddu Kumar Gupta Veer Bhan Rajeev Kumar Kapoor |
| author_facet | Gaurav Pathak Swati Mangla Guddu Kumar Gupta Veer Bhan Rajeev Kumar Kapoor |
| author_sort | Gaurav Pathak |
| collection | DOAJ |
| description | Abstract Around the world, new composites, nanomaterial (NM) products, and tailored nanoparticles (NPs) are constantly being developed. Due to its many applications in the rapidly expanding field of nanotechnology, the manufacturing of nanoparticles is growing. NPs can efficiently migrate to the circulatory system, cross the blood–brain barrier, and have cellular and molecular effects on organs and tissues. There is a need to assess the potentially harmful effects of nanomaterials on plants, animals, microbes, surroundings, and more that will be brought to light in the future. Studies using a variety of model organisms have revealed the potential adverse effects associated with its widespread use. Further in-depth understanding of the toxicity of NPs, potential absorption pathways, and the harmful consequences they may have on living things is still needed. This review investigates the possible pathways of NPs, their potential for toxicity, and the underlying mechanisms that give rise to these effects. Furthermore, the review highlights existing gaps in risk assessment frameworks and underscores the importance of implementing comprehensive risk management strategies tailored to nanoparticle composites. These strategies aim to mitigate potential adverse effects while maximizing the benefits of nanotechnology-enabled materials. Since this topic hasn't been examined in a while, the current laws and regulations set forth by regulatory bodies that define the primary principles and requirements for evaluating novel nanomaterials will also be covered. |
| format | Article |
| id | doaj-art-1aad511ef14e4e108e43778d7be4e0ff |
| institution | OA Journals |
| issn | 3004-9377 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Polymers |
| spelling | doaj-art-1aad511ef14e4e108e43778d7be4e0ff2025-08-20T02:37:58ZengSpringerDiscover Polymers3004-93772025-06-012112710.1007/s44347-025-00023-7Toxicological assessment and risk management of nanoparticles mediated composite materials-critical review: state of the artGaurav Pathak0Swati Mangla1Guddu Kumar Gupta2Veer Bhan3Rajeev Kumar Kapoor4Drosophila Research Laboratory, Department of Biotechnology, University Institute of Engineering and Technology, Maharshi Dayanand UniversityDrosophila Research Laboratory, Department of Biotechnology, University Institute of Engineering and Technology, Maharshi Dayanand UniversityDepartment of Microbiology, Maharshi Dayanand UniversityDrosophila Research Laboratory, Department of Biotechnology, University Institute of Engineering and Technology, Maharshi Dayanand UniversityDepartment of Microbiology, Maharshi Dayanand UniversityAbstract Around the world, new composites, nanomaterial (NM) products, and tailored nanoparticles (NPs) are constantly being developed. Due to its many applications in the rapidly expanding field of nanotechnology, the manufacturing of nanoparticles is growing. NPs can efficiently migrate to the circulatory system, cross the blood–brain barrier, and have cellular and molecular effects on organs and tissues. There is a need to assess the potentially harmful effects of nanomaterials on plants, animals, microbes, surroundings, and more that will be brought to light in the future. Studies using a variety of model organisms have revealed the potential adverse effects associated with its widespread use. Further in-depth understanding of the toxicity of NPs, potential absorption pathways, and the harmful consequences they may have on living things is still needed. This review investigates the possible pathways of NPs, their potential for toxicity, and the underlying mechanisms that give rise to these effects. Furthermore, the review highlights existing gaps in risk assessment frameworks and underscores the importance of implementing comprehensive risk management strategies tailored to nanoparticle composites. These strategies aim to mitigate potential adverse effects while maximizing the benefits of nanotechnology-enabled materials. Since this topic hasn't been examined in a while, the current laws and regulations set forth by regulatory bodies that define the primary principles and requirements for evaluating novel nanomaterials will also be covered.https://doi.org/10.1007/s44347-025-00023-7NanoparticlesNanocompositesModel organismsToxicityNanotubesRegulatory framework |
| spellingShingle | Gaurav Pathak Swati Mangla Guddu Kumar Gupta Veer Bhan Rajeev Kumar Kapoor Toxicological assessment and risk management of nanoparticles mediated composite materials-critical review: state of the art Discover Polymers Nanoparticles Nanocomposites Model organisms Toxicity Nanotubes Regulatory framework |
| title | Toxicological assessment and risk management of nanoparticles mediated composite materials-critical review: state of the art |
| title_full | Toxicological assessment and risk management of nanoparticles mediated composite materials-critical review: state of the art |
| title_fullStr | Toxicological assessment and risk management of nanoparticles mediated composite materials-critical review: state of the art |
| title_full_unstemmed | Toxicological assessment and risk management of nanoparticles mediated composite materials-critical review: state of the art |
| title_short | Toxicological assessment and risk management of nanoparticles mediated composite materials-critical review: state of the art |
| title_sort | toxicological assessment and risk management of nanoparticles mediated composite materials critical review state of the art |
| topic | Nanoparticles Nanocomposites Model organisms Toxicity Nanotubes Regulatory framework |
| url | https://doi.org/10.1007/s44347-025-00023-7 |
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