Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function
A better understanding of the molecular links between obesity and disease is potentially of great benefit for society. In this paper we discuss proposed mechanisms whereby bariatric surgery improves metabolic health, including acute effects on glucose metabolism and long-term effects on metabolic ti...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2011/435245 |
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| _version_ | 1849308577051705344 |
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| author | Simon N. Dankel Vidar Staalesen Bodil Bjørndal Rolf K. Berge Gunnar Mellgren Lena Burri |
| author_facet | Simon N. Dankel Vidar Staalesen Bodil Bjørndal Rolf K. Berge Gunnar Mellgren Lena Burri |
| author_sort | Simon N. Dankel |
| collection | DOAJ |
| description | A better understanding of the molecular links between obesity and disease is potentially of great benefit for society. In this paper we discuss proposed mechanisms whereby bariatric surgery improves metabolic health, including acute effects on glucose metabolism and long-term effects on metabolic tissues (adipose tissue, skeletal muscle, and liver) and mitochondrial function. More short-term randomized controlled trials should be performed that include simultaneous measurement of metabolic parameters in different tissues, such as tissue gene expression, protein profile, and lipid content. By directly comparing different surgical procedures using a wider array of metabolic parameters, one may further unravel the mechanisms of aberrant metabolic regulation in obesity and related disorders. |
| format | Article |
| id | doaj-art-1aad43571be24f188d09da75be06aa98 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-1aad43571be24f188d09da75be06aa982025-08-20T03:54:24ZengWileyJournal of Obesity2090-07082090-07162011-01-01201110.1155/2011/435245435245Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial FunctionSimon N. Dankel0Vidar Staalesen1Bodil Bjørndal2Rolf K. Berge3Gunnar Mellgren4Lena Burri5Institute of Medicine, Haukeland University Hospital, University of Bergen, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, University of Bergen, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, University of Bergen, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, University of Bergen, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, University of Bergen, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, University of Bergen, 5021 Bergen, NorwayA better understanding of the molecular links between obesity and disease is potentially of great benefit for society. In this paper we discuss proposed mechanisms whereby bariatric surgery improves metabolic health, including acute effects on glucose metabolism and long-term effects on metabolic tissues (adipose tissue, skeletal muscle, and liver) and mitochondrial function. More short-term randomized controlled trials should be performed that include simultaneous measurement of metabolic parameters in different tissues, such as tissue gene expression, protein profile, and lipid content. By directly comparing different surgical procedures using a wider array of metabolic parameters, one may further unravel the mechanisms of aberrant metabolic regulation in obesity and related disorders.http://dx.doi.org/10.1155/2011/435245 |
| spellingShingle | Simon N. Dankel Vidar Staalesen Bodil Bjørndal Rolf K. Berge Gunnar Mellgren Lena Burri Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function Journal of Obesity |
| title | Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function |
| title_full | Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function |
| title_fullStr | Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function |
| title_full_unstemmed | Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function |
| title_short | Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function |
| title_sort | tissue specific effects of bariatric surgery including mitochondrial function |
| url | http://dx.doi.org/10.1155/2011/435245 |
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