Assessment of interleukin-6 level and lung inflammatory cells after high-intensity interval training and stay in hypoxic conditions
Background: It seems that the effect of training on improving physical performance is not always associated with beneficial effects on internal organs. So far, the effects of high-intensity interval training and subsequent exposure to hypoxia have not been investigated on lung parenchyma. The purpos...
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Iran Air Force Health Administration
2016-10-01
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| Series: | فصلنامه ابن سینا |
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| Online Access: | http://ebnesina.ajaums.ac.ir/article-1-422-en.pdf |
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| author | M yadegari S riahy Sh mirdar Gh hamidian P mosadegh |
| author_facet | M yadegari S riahy Sh mirdar Gh hamidian P mosadegh |
| author_sort | M yadegari |
| collection | DOAJ |
| description | Background: It seems that the effect of training on improving physical performance is not always associated with beneficial effects on internal organs. So far, the effects of high-intensity interval training and subsequent exposure to hypoxia have not been investigated on lung parenchyma. The purpose of this study was to investigate the effects of chronic hypoxia followed by high-intensity interval training on amount of lung inflammation.
Materials and method: Totally, 24 male Wistar rats (four weeks old, 71±4 gr) were randomly divided into four groups: 6-week control group (n=6), 6-week exercise group (n=6), 9-week control group (n=6), and exercises-hypoxia group (n=6). A training program (running on treadmill) was started with 25 meters per minute and was finished with 70 meters per minute. In each training session, rats performed the intense activity with 10 repetition times and two minutes of rest. The work to rest ratio was 1:2. After six weeks of interval training, rats were kept in a hypoxic chamber for three weeks. At the end, lung tissues extracted for stereological and immunohistochemistry analyses.
Results: Both 6-weeks exercise and exercise-hypoxia groups indicated a significant increase in bronchus-associated lymphoid tissue (BALT), macrophage population and, IL-6 compared to the control group (p<0.05). Also, after three weeks of exposure to hypoxic conditions, BALT volume, macrophage population (p<0.05), and IL-6 (p=0.198) increased compared to 6-week exercise group.
Conclusion: It seems a period of high-intensity interval training could possibly inflamed lung tissue. In addition, chronic hypoxia conditions may aggravate the inflammatory effects of intense exercise. |
| format | Article |
| id | doaj-art-1aaae272edf6423dace1acc8f7e08ab3 |
| institution | OA Journals |
| issn | 1735-9503 2645-4653 |
| language | fas |
| publishDate | 2016-10-01 |
| publisher | Iran Air Force Health Administration |
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| series | فصلنامه ابن سینا |
| spelling | doaj-art-1aaae272edf6423dace1acc8f7e08ab32025-08-20T01:58:11ZfasIran Air Force Health Administrationفصلنامه ابن سینا1735-95032645-46532016-10-011832636Assessment of interleukin-6 level and lung inflammatory cells after high-intensity interval training and stay in hypoxic conditionsM yadegari0S riahy1Sh mirdar2Gh hamidian3P mosadegh4 Department of exercise physiology, Faculty of physical education and sport sciences, University of Mazandaran Faculty of aerospace medicine and subsurface, AJA University of Medical Sciences Department of exercise physiology, Faculty of physical education and sport sciences, University of Mazandaran Department of basic sciences, Faculty of veterinary medicine, Tabriz University Department of exercise physiology, Faculty of physical education and sport sciences, University of Tehran Background: It seems that the effect of training on improving physical performance is not always associated with beneficial effects on internal organs. So far, the effects of high-intensity interval training and subsequent exposure to hypoxia have not been investigated on lung parenchyma. The purpose of this study was to investigate the effects of chronic hypoxia followed by high-intensity interval training on amount of lung inflammation. Materials and method: Totally, 24 male Wistar rats (four weeks old, 71±4 gr) were randomly divided into four groups: 6-week control group (n=6), 6-week exercise group (n=6), 9-week control group (n=6), and exercises-hypoxia group (n=6). A training program (running on treadmill) was started with 25 meters per minute and was finished with 70 meters per minute. In each training session, rats performed the intense activity with 10 repetition times and two minutes of rest. The work to rest ratio was 1:2. After six weeks of interval training, rats were kept in a hypoxic chamber for three weeks. At the end, lung tissues extracted for stereological and immunohistochemistry analyses. Results: Both 6-weeks exercise and exercise-hypoxia groups indicated a significant increase in bronchus-associated lymphoid tissue (BALT), macrophage population and, IL-6 compared to the control group (p<0.05). Also, after three weeks of exposure to hypoxic conditions, BALT volume, macrophage population (p<0.05), and IL-6 (p=0.198) increased compared to 6-week exercise group. Conclusion: It seems a period of high-intensity interval training could possibly inflamed lung tissue. In addition, chronic hypoxia conditions may aggravate the inflammatory effects of intense exercise.http://ebnesina.ajaums.ac.ir/article-1-422-en.pdfexercise traininginflammationhypoxialungmacrophage |
| spellingShingle | M yadegari S riahy Sh mirdar Gh hamidian P mosadegh Assessment of interleukin-6 level and lung inflammatory cells after high-intensity interval training and stay in hypoxic conditions فصلنامه ابن سینا exercise training inflammation hypoxia lung macrophage |
| title | Assessment of interleukin-6 level and lung inflammatory cells after high-intensity interval training and stay in hypoxic conditions |
| title_full | Assessment of interleukin-6 level and lung inflammatory cells after high-intensity interval training and stay in hypoxic conditions |
| title_fullStr | Assessment of interleukin-6 level and lung inflammatory cells after high-intensity interval training and stay in hypoxic conditions |
| title_full_unstemmed | Assessment of interleukin-6 level and lung inflammatory cells after high-intensity interval training and stay in hypoxic conditions |
| title_short | Assessment of interleukin-6 level and lung inflammatory cells after high-intensity interval training and stay in hypoxic conditions |
| title_sort | assessment of interleukin 6 level and lung inflammatory cells after high intensity interval training and stay in hypoxic conditions |
| topic | exercise training inflammation hypoxia lung macrophage |
| url | http://ebnesina.ajaums.ac.ir/article-1-422-en.pdf |
| work_keys_str_mv | AT myadegari assessmentofinterleukin6levelandlunginflammatorycellsafterhighintensityintervaltrainingandstayinhypoxicconditions AT sriahy assessmentofinterleukin6levelandlunginflammatorycellsafterhighintensityintervaltrainingandstayinhypoxicconditions AT shmirdar assessmentofinterleukin6levelandlunginflammatorycellsafterhighintensityintervaltrainingandstayinhypoxicconditions AT ghhamidian assessmentofinterleukin6levelandlunginflammatorycellsafterhighintensityintervaltrainingandstayinhypoxicconditions AT pmosadegh assessmentofinterleukin6levelandlunginflammatorycellsafterhighintensityintervaltrainingandstayinhypoxicconditions |