Fast Prototyping and Ex Vivo Evaluation of Dissolvable Millineedle Patches Made by Solvent Casting from CO2 Laser Ablated Elastomer Molds
Abstract In this study, a highly feasible fabrication approach is explored to make flexible elastomer molds for producing transdermal patches comprising an array of millimeter‐long dissolvable polymer needles. The millineedles (MilN), produced in both polyvinylpyrrolidone and carboxymethyl cellulose...
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Wiley-VCH
2025-05-01
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| Series: | Advanced Materials Interfaces |
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| Online Access: | https://doi.org/10.1002/admi.202400858 |
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| author | Matteo Tollemeto Lasse Højlund Eklund Thamdrup Veni Mahalingam Gavrielle R. Untracht Tania Patiño Padial Peter Eskil Andersen Jan van Hest Anja Boisen |
| author_facet | Matteo Tollemeto Lasse Højlund Eklund Thamdrup Veni Mahalingam Gavrielle R. Untracht Tania Patiño Padial Peter Eskil Andersen Jan van Hest Anja Boisen |
| author_sort | Matteo Tollemeto |
| collection | DOAJ |
| description | Abstract In this study, a highly feasible fabrication approach is explored to make flexible elastomer molds for producing transdermal patches comprising an array of millimeter‐long dissolvable polymer needles. The millineedles (MilN), produced in both polyvinylpyrrolidone and carboxymethyl cellulose, are targeting efficient transdermal drug delivery. Employing a fast, inexpensive, and reproducible CO2 laser ablation process, polydimethylsiloxane molds are successfully created measuring 10 × 10 mm2, with arrays of conical cavities reaching depths of 1288.17 ± 128.93 µm. While this versatile fabrication technique is previously demonstrated for microneedles, it lacked a comprehensive performance evaluation of the produced needles. The study fills this gap by providing significant experimental data on the in vitro and ex vivo performance of the MilN patches. The applicability of the method is demonstrated by systematically casting and testing patches comprising various hydrophilic polymers and compounds. Mechanical testing underscored the resilience of MilN arrays, enduring compression forces up to 36 N for 30 s. Skin penetration efficiency, assessed in Parafilm M and porcine skin, revealed an insertion depth of ≈560 µm for polyvinylpyrrolidone MilN. |
| format | Article |
| id | doaj-art-1aaaacd030fb4f8c877904cb8a381c84 |
| institution | Kabale University |
| issn | 2196-7350 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley-VCH |
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| series | Advanced Materials Interfaces |
| spelling | doaj-art-1aaaacd030fb4f8c877904cb8a381c842025-08-20T03:53:51ZengWiley-VCHAdvanced Materials Interfaces2196-73502025-05-011210n/an/a10.1002/admi.202400858Fast Prototyping and Ex Vivo Evaluation of Dissolvable Millineedle Patches Made by Solvent Casting from CO2 Laser Ablated Elastomer MoldsMatteo Tollemeto0Lasse Højlund Eklund Thamdrup1Veni Mahalingam2Gavrielle R. Untracht3Tania Patiño Padial4Peter Eskil Andersen5Jan van Hest6Anja Boisen7The Danish National Research Foundation and Villum Foundation's Center IDUN Department of Health Technology Technical University of Denmark Kgs. Lyngby 2800 DenmarkThe Danish National Research Foundation and Villum Foundation's Center IDUN Department of Health Technology Technical University of Denmark Kgs. Lyngby 2800 DenmarkThe Danish National Research Foundation and Villum Foundation's Center IDUN Department of Health Technology Technical University of Denmark Kgs. Lyngby 2800 DenmarkOASIS Department of Health Technology Technical University of Denmark Kgs. Lyngby 2800 DenmarkDepartment of Biomedical Engineering Institute for Complex Molecular Systems Eindhoven University of Technology Eindhoven 5612 AZ The NetherlandsOASIS Department of Health Technology Technical University of Denmark Kgs. Lyngby 2800 DenmarkDepartment of Biomedical Engineering Institute for Complex Molecular Systems Eindhoven University of Technology Eindhoven 5612 AZ The NetherlandsThe Danish National Research Foundation and Villum Foundation's Center IDUN Department of Health Technology Technical University of Denmark Kgs. Lyngby 2800 DenmarkAbstract In this study, a highly feasible fabrication approach is explored to make flexible elastomer molds for producing transdermal patches comprising an array of millimeter‐long dissolvable polymer needles. The millineedles (MilN), produced in both polyvinylpyrrolidone and carboxymethyl cellulose, are targeting efficient transdermal drug delivery. Employing a fast, inexpensive, and reproducible CO2 laser ablation process, polydimethylsiloxane molds are successfully created measuring 10 × 10 mm2, with arrays of conical cavities reaching depths of 1288.17 ± 128.93 µm. While this versatile fabrication technique is previously demonstrated for microneedles, it lacked a comprehensive performance evaluation of the produced needles. The study fills this gap by providing significant experimental data on the in vitro and ex vivo performance of the MilN patches. The applicability of the method is demonstrated by systematically casting and testing patches comprising various hydrophilic polymers and compounds. Mechanical testing underscored the resilience of MilN arrays, enduring compression forces up to 36 N for 30 s. Skin penetration efficiency, assessed in Parafilm M and porcine skin, revealed an insertion depth of ≈560 µm for polyvinylpyrrolidone MilN.https://doi.org/10.1002/admi.202400858mesoporous silica nanoparticlesmillineedlesOCTtransdermal delivery |
| spellingShingle | Matteo Tollemeto Lasse Højlund Eklund Thamdrup Veni Mahalingam Gavrielle R. Untracht Tania Patiño Padial Peter Eskil Andersen Jan van Hest Anja Boisen Fast Prototyping and Ex Vivo Evaluation of Dissolvable Millineedle Patches Made by Solvent Casting from CO2 Laser Ablated Elastomer Molds Advanced Materials Interfaces mesoporous silica nanoparticles millineedles OCT transdermal delivery |
| title | Fast Prototyping and Ex Vivo Evaluation of Dissolvable Millineedle Patches Made by Solvent Casting from CO2 Laser Ablated Elastomer Molds |
| title_full | Fast Prototyping and Ex Vivo Evaluation of Dissolvable Millineedle Patches Made by Solvent Casting from CO2 Laser Ablated Elastomer Molds |
| title_fullStr | Fast Prototyping and Ex Vivo Evaluation of Dissolvable Millineedle Patches Made by Solvent Casting from CO2 Laser Ablated Elastomer Molds |
| title_full_unstemmed | Fast Prototyping and Ex Vivo Evaluation of Dissolvable Millineedle Patches Made by Solvent Casting from CO2 Laser Ablated Elastomer Molds |
| title_short | Fast Prototyping and Ex Vivo Evaluation of Dissolvable Millineedle Patches Made by Solvent Casting from CO2 Laser Ablated Elastomer Molds |
| title_sort | fast prototyping and ex vivo evaluation of dissolvable millineedle patches made by solvent casting from co2 laser ablated elastomer molds |
| topic | mesoporous silica nanoparticles millineedles OCT transdermal delivery |
| url | https://doi.org/10.1002/admi.202400858 |
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