Tip-enhanced Raman scattering of glucose molecules
Glucose molecules are of great significance being one of the most important molecules in metabolic chain. However, due to the small Raman scattering cross-section and weak/non-adsorption on bare metals, accurately obtaining their "fingerprint information" remains a huge obstacle. Herein, w...
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| Format: | Article |
| Language: | English |
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Editorial Office of Opto-Electronic Journals, Institute of Optics and Electronics, CAS, China
2025-05-01
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| Series: | Opto-Electronic Science |
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| Online Access: | https://www.oejournal.org/article/doi/10.29026/oes.2025.240027 |
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| author | Zhonglin Xie Chao Meng Donghua Yue Lei Xu Ting Mei Wending Zhang |
| author_facet | Zhonglin Xie Chao Meng Donghua Yue Lei Xu Ting Mei Wending Zhang |
| author_sort | Zhonglin Xie |
| collection | DOAJ |
| description | Glucose molecules are of great significance being one of the most important molecules in metabolic chain. However, due to the small Raman scattering cross-section and weak/non-adsorption on bare metals, accurately obtaining their "fingerprint information" remains a huge obstacle. Herein, we developed a tip-enhanced Raman scattering (TERS) technique to address this challenge. Adopting an optical fiber radial vector mode internally illuminates the plasmonic fiber tip to effectively suppress the background noise while generating a strong electric-field enhanced tip hotspot. Furthermore, the tip hotspot approaching the glucose molecules was manipulated via the shear-force feedback to provide more freedom for selecting substrates. Consequently, our TERS technique achieves the visualization of all Raman modes of glucose molecules within spectral window of 400–3200 cm−1, which is not achievable through the far-field/surface-enhanced Raman, or the existing TERS techniques. Our TERS technique offers a powerful tool for accurately identifying Raman scattering of molecules, paving the way for biomolecular analysis. |
| format | Article |
| id | doaj-art-1aa9def380264eb0a7ec6d3ee254f579 |
| institution | Kabale University |
| issn | 2097-0382 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Editorial Office of Opto-Electronic Journals, Institute of Optics and Electronics, CAS, China |
| record_format | Article |
| series | Opto-Electronic Science |
| spelling | doaj-art-1aa9def380264eb0a7ec6d3ee254f5792025-08-20T03:33:15ZengEditorial Office of Opto-Electronic Journals, Institute of Optics and Electronics, CAS, ChinaOpto-Electronic Science2097-03822025-05-01451810.29026/oes.2025.240027oes-2024-0027Tip-enhanced Raman scattering of glucose moleculesZhonglin Xie0Chao Meng1Donghua Yue2Lei Xu3Ting Mei4Wending Zhang5Key Laboratory of Light Field Manipulation and Information Acquisition, Ministry of Industry and Information Technology, School of Physical Science and Technology, Northwestern Polytechnical University, Xi'an 710129, ChinaKey Laboratory of Light Field Manipulation and Information Acquisition, Ministry of Industry and Information Technology, School of Physical Science and Technology, Northwestern Polytechnical University, Xi'an 710129, ChinaKey Laboratory of Light Field Manipulation and Information Acquisition, Ministry of Industry and Information Technology, School of Physical Science and Technology, Northwestern Polytechnical University, Xi'an 710129, ChinaAdvanced Optics Photonics Laboratory, Department of Engineering, School of Science Technology, Nottingham Trent University, Nottingham NG11 8NS, United KingdomKey Laboratory of Light Field Manipulation and Information Acquisition, Ministry of Industry and Information Technology, School of Physical Science and Technology, Northwestern Polytechnical University, Xi'an 710129, ChinaKey Laboratory of Light Field Manipulation and Information Acquisition, Ministry of Industry and Information Technology, School of Physical Science and Technology, Northwestern Polytechnical University, Xi'an 710129, ChinaGlucose molecules are of great significance being one of the most important molecules in metabolic chain. However, due to the small Raman scattering cross-section and weak/non-adsorption on bare metals, accurately obtaining their "fingerprint information" remains a huge obstacle. Herein, we developed a tip-enhanced Raman scattering (TERS) technique to address this challenge. Adopting an optical fiber radial vector mode internally illuminates the plasmonic fiber tip to effectively suppress the background noise while generating a strong electric-field enhanced tip hotspot. Furthermore, the tip hotspot approaching the glucose molecules was manipulated via the shear-force feedback to provide more freedom for selecting substrates. Consequently, our TERS technique achieves the visualization of all Raman modes of glucose molecules within spectral window of 400–3200 cm−1, which is not achievable through the far-field/surface-enhanced Raman, or the existing TERS techniques. Our TERS technique offers a powerful tool for accurately identifying Raman scattering of molecules, paving the way for biomolecular analysis.https://www.oejournal.org/article/doi/10.29026/oes.2025.240027tip-enhanced raman scatteringscanning near-field optical microscopefiber vector light fieldtip nanofocusing light source |
| spellingShingle | Zhonglin Xie Chao Meng Donghua Yue Lei Xu Ting Mei Wending Zhang Tip-enhanced Raman scattering of glucose molecules Opto-Electronic Science tip-enhanced raman scattering scanning near-field optical microscope fiber vector light field tip nanofocusing light source |
| title | Tip-enhanced Raman scattering of glucose molecules |
| title_full | Tip-enhanced Raman scattering of glucose molecules |
| title_fullStr | Tip-enhanced Raman scattering of glucose molecules |
| title_full_unstemmed | Tip-enhanced Raman scattering of glucose molecules |
| title_short | Tip-enhanced Raman scattering of glucose molecules |
| title_sort | tip enhanced raman scattering of glucose molecules |
| topic | tip-enhanced raman scattering scanning near-field optical microscope fiber vector light field tip nanofocusing light source |
| url | https://www.oejournal.org/article/doi/10.29026/oes.2025.240027 |
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