Tip-enhanced Raman scattering of glucose molecules
Glucose molecules are of great significance being one of the most important molecules in metabolic chain. However, due to the small Raman scattering cross-section and weak/non-adsorption on bare metals, accurately obtaining their "fingerprint information" remains a huge obstacle. Herein, w...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Office of Opto-Electronic Journals, Institute of Optics and Electronics, CAS, China
2025-05-01
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| Series: | Opto-Electronic Science |
| Subjects: | |
| Online Access: | https://www.oejournal.org/article/doi/10.29026/oes.2025.240027 |
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| Summary: | Glucose molecules are of great significance being one of the most important molecules in metabolic chain. However, due to the small Raman scattering cross-section and weak/non-adsorption on bare metals, accurately obtaining their "fingerprint information" remains a huge obstacle. Herein, we developed a tip-enhanced Raman scattering (TERS) technique to address this challenge. Adopting an optical fiber radial vector mode internally illuminates the plasmonic fiber tip to effectively suppress the background noise while generating a strong electric-field enhanced tip hotspot. Furthermore, the tip hotspot approaching the glucose molecules was manipulated via the shear-force feedback to provide more freedom for selecting substrates. Consequently, our TERS technique achieves the visualization of all Raman modes of glucose molecules within spectral window of 400–3200 cm−1, which is not achievable through the far-field/surface-enhanced Raman, or the existing TERS techniques. Our TERS technique offers a powerful tool for accurately identifying Raman scattering of molecules, paving the way for biomolecular analysis. |
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| ISSN: | 2097-0382 |