Treatment strategies for unruptured intracranial aneurysms in the Chinese population: China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA)
Abstract Background Intracranial aneurysm is a leading cause of subarachnoid hemorrhage and affects approximately 7% of the Chinese population, posing a significant public health concern. Due to the lack of a national cohort of unruptured intracranial aneurysms (UIAs) in China, optimal surgical mana...
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| Language: | English |
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BMC
2025-04-01
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| Series: | Chinese Neurosurgical Journal |
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| Online Access: | https://doi.org/10.1186/s41016-025-00394-7 |
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| author | Kaige Zheng Zheng Wen Kaiwen Wang Shaohua Mo Jun Wu Xiaolin Chen Bing Zhao Qingyuan Liu Shuo Wang |
| author_facet | Kaige Zheng Zheng Wen Kaiwen Wang Shaohua Mo Jun Wu Xiaolin Chen Bing Zhao Qingyuan Liu Shuo Wang |
| author_sort | Kaige Zheng |
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| description | Abstract Background Intracranial aneurysm is a leading cause of subarachnoid hemorrhage and affects approximately 7% of the Chinese population, posing a significant public health concern. Due to the lack of a national cohort of unruptured intracranial aneurysms (UIAs) in China, optimal surgical management for UIAs remain insufficiently explored. Methods The China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA) is a national, prospective, observational, multi-center registry study designed to identify optimal surgical management for UIAs in the Chinese population. Eligible patients were recruited from 83 regional neurological centers in China between December 2021 and December 2022. All patients will be followed up routinely for at least two years. Results A total of 25,438 patients with UIAs have been enrolled in the study, of whom 9794 (38.5%) were male, with a median age of 59 years (interquartile range: 52–67 years). The mean follow-up period was 4.28 years (interquartile range: 2.86–6.37 years). Among the patients, 6,712 (26.4%) patients underwent microsurgical clipping, and 18,726 (73.6%) patients underwent endovascular treatment, including 3,017 (16.1%) receiving coil alone or balloon-assisted coiling, 11,431 (61.1%) underwent stent-assisted coiling, and 4,278 (22.8%) treated with flow diverters. Comprehensive data collection encompassed 874,890 demographic and clinical records, 42,109 radiological records, 13,528 hemodynamic records, and 12,727 biological records, with a lost-to-follow-up rate of 5.4% and a data-missing rate of 8.3%. Conclusions The ChTUIA study represents the first national prospective investigation into surgical management protocols and treatment trends toward UIAs in the Chinese population. This study will provide critical evidence to guide the clinical management of UIA patients. Trial registration NCT05844163 ( https://clinicaltrials.gov/study/NCT05844163 ). |
| format | Article |
| id | doaj-art-1aa9cec192cb4fb297032e01d35a96d3 |
| institution | Kabale University |
| issn | 2057-4967 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Neurosurgical Journal |
| spelling | doaj-art-1aa9cec192cb4fb297032e01d35a96d32025-08-24T11:08:46ZengBMCChinese Neurosurgical Journal2057-49672025-04-011111810.1186/s41016-025-00394-7Treatment strategies for unruptured intracranial aneurysms in the Chinese population: China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA)Kaige Zheng0Zheng Wen1Kaiwen Wang2Shaohua Mo3Jun Wu4Xiaolin Chen5Bing Zhao6Qingyuan Liu7Shuo Wang8Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Background Intracranial aneurysm is a leading cause of subarachnoid hemorrhage and affects approximately 7% of the Chinese population, posing a significant public health concern. Due to the lack of a national cohort of unruptured intracranial aneurysms (UIAs) in China, optimal surgical management for UIAs remain insufficiently explored. Methods The China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA) is a national, prospective, observational, multi-center registry study designed to identify optimal surgical management for UIAs in the Chinese population. Eligible patients were recruited from 83 regional neurological centers in China between December 2021 and December 2022. All patients will be followed up routinely for at least two years. Results A total of 25,438 patients with UIAs have been enrolled in the study, of whom 9794 (38.5%) were male, with a median age of 59 years (interquartile range: 52–67 years). The mean follow-up period was 4.28 years (interquartile range: 2.86–6.37 years). Among the patients, 6,712 (26.4%) patients underwent microsurgical clipping, and 18,726 (73.6%) patients underwent endovascular treatment, including 3,017 (16.1%) receiving coil alone or balloon-assisted coiling, 11,431 (61.1%) underwent stent-assisted coiling, and 4,278 (22.8%) treated with flow diverters. Comprehensive data collection encompassed 874,890 demographic and clinical records, 42,109 radiological records, 13,528 hemodynamic records, and 12,727 biological records, with a lost-to-follow-up rate of 5.4% and a data-missing rate of 8.3%. Conclusions The ChTUIA study represents the first national prospective investigation into surgical management protocols and treatment trends toward UIAs in the Chinese population. This study will provide critical evidence to guide the clinical management of UIA patients. Trial registration NCT05844163 ( https://clinicaltrials.gov/study/NCT05844163 ).https://doi.org/10.1186/s41016-025-00394-7Unruptured intracranial aneurysmTreatmentEndovascular treatmentSurgical clippingComplication |
| spellingShingle | Kaige Zheng Zheng Wen Kaiwen Wang Shaohua Mo Jun Wu Xiaolin Chen Bing Zhao Qingyuan Liu Shuo Wang Treatment strategies for unruptured intracranial aneurysms in the Chinese population: China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA) Chinese Neurosurgical Journal Unruptured intracranial aneurysm Treatment Endovascular treatment Surgical clipping Complication |
| title | Treatment strategies for unruptured intracranial aneurysms in the Chinese population: China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA) |
| title_full | Treatment strategies for unruptured intracranial aneurysms in the Chinese population: China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA) |
| title_fullStr | Treatment strategies for unruptured intracranial aneurysms in the Chinese population: China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA) |
| title_full_unstemmed | Treatment strategies for unruptured intracranial aneurysms in the Chinese population: China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA) |
| title_short | Treatment strategies for unruptured intracranial aneurysms in the Chinese population: China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA) |
| title_sort | treatment strategies for unruptured intracranial aneurysms in the chinese population china treatment trial for unruptured intracranial aneurysm chtuia |
| topic | Unruptured intracranial aneurysm Treatment Endovascular treatment Surgical clipping Complication |
| url | https://doi.org/10.1186/s41016-025-00394-7 |
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