Translation, cross-cultural adaptation, and validation of the HCT frailty scale for hematopoietic stem cell transplant candidates: an observational study
Introduction: Hematopoietic stem cell transplantation (HSCT) is a treatment option for patients with hematologic malignancies. The aim of this study is to validate the Hematopoietic Cell Transplantation Frailty Scale in a Chilean population. Methods: This was a cross-sectional scale validation study...
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| Format: | Article |
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Elsevier
2025-07-01
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| Series: | Hematology, Transfusion and Cell Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137925002019 |
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| author | Luz Lorca Barbara Puga Larrain Ivana Leao Ribeiro Ivana Gonzalez Valdivia Angelia Fernández Hermoso Francisca Bass Maturana Francisco Canelo Lazcano |
| author_facet | Luz Lorca Barbara Puga Larrain Ivana Leao Ribeiro Ivana Gonzalez Valdivia Angelia Fernández Hermoso Francisca Bass Maturana Francisco Canelo Lazcano |
| author_sort | Luz Lorca |
| collection | DOAJ |
| description | Introduction: Hematopoietic stem cell transplantation (HSCT) is a treatment option for patients with hematologic malignancies. The aim of this study is to validate the Hematopoietic Cell Transplantation Frailty Scale in a Chilean population. Methods: This was a cross-sectional scale validation study. The sample consisted of patients with various hematologic malignancies who were transplantation candidates. The study had two stages: (1) translation (forward and backward) and (2) psychometric analysis, including face validity, test-retest reliability, and content validity. Descriptive analyses included mean, standard deviation, and the 95 % confidence interval. Reliability was assessed with Spearman's correlation, and content validity used Kendall's W test. Results: Fifty-four patients (53.7 % women) were included, with multiple myeloma being the most frequent diagnosis (33.3 %). Positive and strong correlations were identified (Spearman's Rho [ρ]: 1.0; p-value <0.001) for all items on the scale. Regarding content validity, there was agreement among evaluators for the categories of relevance and coherence (p-value <0.01; Kendall's W range: 0.13–0.17) but not for “clarity” (p-value = 0.11; Kendall's W: 0.07). Some terms in the content were adjusted without affecting the overall structure of the scale. In the retest analysis, descriptive values were similar to the initial test. Conclusion: The Spanish version of the Hematopoietic Cell Transplantation Frailty Scale for Chile is conceptually and linguistically equivalent to the original instrument. Additionally, it demonstrated adequate psychometric properties in terms of validity and reliability. |
| format | Article |
| id | doaj-art-1aa0a5ce679c4ccfb663d8a170d8618e |
| institution | Kabale University |
| issn | 2531-1379 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj-art-1aa0a5ce679c4ccfb663d8a170d8618e2025-08-20T03:38:59ZengElsevierHematology, Transfusion and Cell Therapy2531-13792025-07-0147310393310.1016/j.htct.2025.103933Translation, cross-cultural adaptation, and validation of the HCT frailty scale for hematopoietic stem cell transplant candidates: an observational studyLuz Lorca0Barbara Puga Larrain1Ivana Leao Ribeiro2Ivana Gonzalez Valdivia3Angelia Fernández Hermoso4Francisca Bass Maturana5Francisco Canelo Lazcano6Department of Physical Medicine and Rehabilitation, Hospital del Salvador, Santiago, Chile; Corresponding author. Hospital del Salvador, Servicio de Salud Metropolitano Oriente, Santiago de Chile.Department of Intensive Hematology, Hospital del Salvador, Santiago, ChileFaculty of Healthy Sciences, Universidad Católica del Maule, Talca, Chile; Faculty of Healthy, Universidad Santo Tomás, Talca, ChileDepartment of Physical Medicine and Rehabilitation, Hospital del Salvador, Santiago, ChileDepartment of Intensive Hematology, Hospital del Salvador, Santiago, ChileDepartment of Intensive Hematology, Hospital del Salvador, Santiago, ChileDepartment of Intensive Hematology, Hospital del Salvador, Santiago, ChileIntroduction: Hematopoietic stem cell transplantation (HSCT) is a treatment option for patients with hematologic malignancies. The aim of this study is to validate the Hematopoietic Cell Transplantation Frailty Scale in a Chilean population. Methods: This was a cross-sectional scale validation study. The sample consisted of patients with various hematologic malignancies who were transplantation candidates. The study had two stages: (1) translation (forward and backward) and (2) psychometric analysis, including face validity, test-retest reliability, and content validity. Descriptive analyses included mean, standard deviation, and the 95 % confidence interval. Reliability was assessed with Spearman's correlation, and content validity used Kendall's W test. Results: Fifty-four patients (53.7 % women) were included, with multiple myeloma being the most frequent diagnosis (33.3 %). Positive and strong correlations were identified (Spearman's Rho [ρ]: 1.0; p-value <0.001) for all items on the scale. Regarding content validity, there was agreement among evaluators for the categories of relevance and coherence (p-value <0.01; Kendall's W range: 0.13–0.17) but not for “clarity” (p-value = 0.11; Kendall's W: 0.07). Some terms in the content were adjusted without affecting the overall structure of the scale. In the retest analysis, descriptive values were similar to the initial test. Conclusion: The Spanish version of the Hematopoietic Cell Transplantation Frailty Scale for Chile is conceptually and linguistically equivalent to the original instrument. Additionally, it demonstrated adequate psychometric properties in terms of validity and reliability.http://www.sciencedirect.com/science/article/pii/S2531137925002019Hematopoietic progenitor cell transplantationFrailtyFunctionalityValidation studyHCT Frailty Scale |
| spellingShingle | Luz Lorca Barbara Puga Larrain Ivana Leao Ribeiro Ivana Gonzalez Valdivia Angelia Fernández Hermoso Francisca Bass Maturana Francisco Canelo Lazcano Translation, cross-cultural adaptation, and validation of the HCT frailty scale for hematopoietic stem cell transplant candidates: an observational study Hematology, Transfusion and Cell Therapy Hematopoietic progenitor cell transplantation Frailty Functionality Validation study HCT Frailty Scale |
| title | Translation, cross-cultural adaptation, and validation of the HCT frailty scale for hematopoietic stem cell transplant candidates: an observational study |
| title_full | Translation, cross-cultural adaptation, and validation of the HCT frailty scale for hematopoietic stem cell transplant candidates: an observational study |
| title_fullStr | Translation, cross-cultural adaptation, and validation of the HCT frailty scale for hematopoietic stem cell transplant candidates: an observational study |
| title_full_unstemmed | Translation, cross-cultural adaptation, and validation of the HCT frailty scale for hematopoietic stem cell transplant candidates: an observational study |
| title_short | Translation, cross-cultural adaptation, and validation of the HCT frailty scale for hematopoietic stem cell transplant candidates: an observational study |
| title_sort | translation cross cultural adaptation and validation of the hct frailty scale for hematopoietic stem cell transplant candidates an observational study |
| topic | Hematopoietic progenitor cell transplantation Frailty Functionality Validation study HCT Frailty Scale |
| url | http://www.sciencedirect.com/science/article/pii/S2531137925002019 |
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