Impact of the presence of a prosthetic implant and transition to oral stepdown therapy on relapse rates and mortality in uncomplicated Staphylococcus aureus bacteremia treated with 14 days of antibiotics: a retrospective cohort study

Impact of the presence of a prosthetic implant and transition to oral stepdown therapy on relapse rates and mortality in uncomplicated Staphylococcus aureus bacteremia treated with 14 days of antibiotics: a retrospective cohort study

ABSTRACT The aim of this single-center, retrospective observational study was to evaluate the effects of having a prosthetic implant (PI) and of changing from intravenous to oral antibiotics (oral stepdown therapy [OST]) on the risk of relapse in patients with otherwise uncomplicated Staphylococcus...

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Bibliographic Details
Main Authors: Damien Blez, Luc Labarbe, Patrick Grohs, Jean-Luc Mainardi, Jean-Philippe Barnier, David Lebeaux, Marie Dubert
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:Microbiology Spectrum
Subjects:
Staphylocococcus aureus
prosthesis
device
oral stepdown therapy
short-course antibiotic therapy
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03337-24
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