Characteristics of Corticosteroid‐Resistant Secondary Immune Thrombocytopenia Associated With Connective Tissue Diseases in China: A Retrospective Comparative Study
ABSTRACT Objective Corticosteroid‐resistant secondary immune thrombocytopenia (ITP) is a challenging condition in clinical practice. This study aimed to explore the clinical and immunological characteristics of corticosteroid‐resistant secondary ITP associated with connective tissue diseases (CTD‐IT...
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Wiley
2025-07-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.70236 |
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| author | Yangchun Chen Yingying Shi Yuechi Sun Yun Peng Guixiu Shi Yuan Liu Shiju Chen |
| author_facet | Yangchun Chen Yingying Shi Yuechi Sun Yun Peng Guixiu Shi Yuan Liu Shiju Chen |
| author_sort | Yangchun Chen |
| collection | DOAJ |
| description | ABSTRACT Objective Corticosteroid‐resistant secondary immune thrombocytopenia (ITP) is a challenging condition in clinical practice. This study aimed to explore the clinical and immunological characteristics of corticosteroid‐resistant secondary ITP associated with connective tissue diseases (CTD‐ITP). Methods We conducted a retrospective analysis of 201 CTD‐ITP hospitalized patients between 2014 and 2022. Patients were categorized as corticosteroid‐resistant or corticosteroid‐sensitive, and their demographic, clinical, and immunological data were compared. Logistic regression analysis was employed to identify independent predictors of corticosteroid resistance. Results Corticosteroid resistance was observed in 27.4% of patients. Compared with the corticosteroid‐sensitive group, the corticosteroid‐resistant group exhibited a higher percentage of CD3+ T cell (71.38% vs. 64.70%, p = 0.004) and CD3+CD8+ T cell (38.55% vs. 28.95%, p = 0.003), but a lower percentage of CD19+ B cell (13.70% vs. 22.45%, p = 0.001) in peripheral blood. No significant differences were found in other demographics, clinical features, or autoantibody profiles. The multivariable logistic regression analysis showed that higher percentage of CD3+CD8+ T cells (OR = 1.170, 95% CI: 1.014–1.350, p = 0.031) was an independent risk factor for corticosteroid resistance in CTD‐ITP patients. Conclusion This study revealed the potential role of higher CD3+CD8+ T cells in corticosteroid resistance among CTD‐ITP patients, and provided the potential biomarker for predicting corticosteroid therapy response. |
| format | Article |
| id | doaj-art-1a991ccd63da452abb345d834d4e58b0 |
| institution | DOAJ |
| issn | 2050-4527 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-1a991ccd63da452abb345d834d4e58b02025-08-20T02:46:35ZengWileyImmunity, Inflammation and Disease2050-45272025-07-01137n/an/a10.1002/iid3.70236Characteristics of Corticosteroid‐Resistant Secondary Immune Thrombocytopenia Associated With Connective Tissue Diseases in China: A Retrospective Comparative StudyYangchun Chen0Yingying Shi1Yuechi Sun2Yun Peng3Guixiu Shi4Yuan Liu5Shiju Chen6Department of Rheumatology and Clinical Immunology School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University Xiamen ChinaDepartment of Rheumatology and Clinical Immunology School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University Xiamen ChinaDepartment of Rheumatology and Clinical Immunology School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University Xiamen ChinaDepartment of Rheumatology and Clinical Immunology School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University Xiamen ChinaDepartment of Rheumatology and Clinical Immunology School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University Xiamen ChinaDepartment of Rheumatology and Clinical Immunology School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University Xiamen ChinaDepartment of Rheumatology and Clinical Immunology School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University Xiamen ChinaABSTRACT Objective Corticosteroid‐resistant secondary immune thrombocytopenia (ITP) is a challenging condition in clinical practice. This study aimed to explore the clinical and immunological characteristics of corticosteroid‐resistant secondary ITP associated with connective tissue diseases (CTD‐ITP). Methods We conducted a retrospective analysis of 201 CTD‐ITP hospitalized patients between 2014 and 2022. Patients were categorized as corticosteroid‐resistant or corticosteroid‐sensitive, and their demographic, clinical, and immunological data were compared. Logistic regression analysis was employed to identify independent predictors of corticosteroid resistance. Results Corticosteroid resistance was observed in 27.4% of patients. Compared with the corticosteroid‐sensitive group, the corticosteroid‐resistant group exhibited a higher percentage of CD3+ T cell (71.38% vs. 64.70%, p = 0.004) and CD3+CD8+ T cell (38.55% vs. 28.95%, p = 0.003), but a lower percentage of CD19+ B cell (13.70% vs. 22.45%, p = 0.001) in peripheral blood. No significant differences were found in other demographics, clinical features, or autoantibody profiles. The multivariable logistic regression analysis showed that higher percentage of CD3+CD8+ T cells (OR = 1.170, 95% CI: 1.014–1.350, p = 0.031) was an independent risk factor for corticosteroid resistance in CTD‐ITP patients. Conclusion This study revealed the potential role of higher CD3+CD8+ T cells in corticosteroid resistance among CTD‐ITP patients, and provided the potential biomarker for predicting corticosteroid therapy response.https://doi.org/10.1002/iid3.70236CD8+ T cell percentageconnective tissue diseasecorticosteroid‐resistantsecondary immune thrombocytopenia |
| spellingShingle | Yangchun Chen Yingying Shi Yuechi Sun Yun Peng Guixiu Shi Yuan Liu Shiju Chen Characteristics of Corticosteroid‐Resistant Secondary Immune Thrombocytopenia Associated With Connective Tissue Diseases in China: A Retrospective Comparative Study Immunity, Inflammation and Disease CD8+ T cell percentage connective tissue disease corticosteroid‐resistant secondary immune thrombocytopenia |
| title | Characteristics of Corticosteroid‐Resistant Secondary Immune Thrombocytopenia Associated With Connective Tissue Diseases in China: A Retrospective Comparative Study |
| title_full | Characteristics of Corticosteroid‐Resistant Secondary Immune Thrombocytopenia Associated With Connective Tissue Diseases in China: A Retrospective Comparative Study |
| title_fullStr | Characteristics of Corticosteroid‐Resistant Secondary Immune Thrombocytopenia Associated With Connective Tissue Diseases in China: A Retrospective Comparative Study |
| title_full_unstemmed | Characteristics of Corticosteroid‐Resistant Secondary Immune Thrombocytopenia Associated With Connective Tissue Diseases in China: A Retrospective Comparative Study |
| title_short | Characteristics of Corticosteroid‐Resistant Secondary Immune Thrombocytopenia Associated With Connective Tissue Diseases in China: A Retrospective Comparative Study |
| title_sort | characteristics of corticosteroid resistant secondary immune thrombocytopenia associated with connective tissue diseases in china a retrospective comparative study |
| topic | CD8+ T cell percentage connective tissue disease corticosteroid‐resistant secondary immune thrombocytopenia |
| url | https://doi.org/10.1002/iid3.70236 |
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