Spermine delivered by ZIF90 nanoparticles alleviates atherosclerosis by targeted inhibition of macrophage ferroptosis in plaque

Spermine delivered by ZIF90 nanoparticles alleviates atherosclerosis by targeted inhibition of macrophage ferroptosis in plaque

Abstract Background Nowadays, emerging evidence have suggested that the ferroptosis of macrophages could contribute to the progression of atherosclerosis (AS). Meanwhile, Spermine (Sp) could serve as an endogenous small molecule exhibiting a wide range of cardiovascular protective effects. Methods Z...

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Main Authors: Yuwu Chen, Biyi Xu, Quan Lin, Xinxin Zhu, Ying Lv, Xiaoxuan Bai, Xiuzhu Weng, Jie Du, Man Li, Yuxiao Zhu, Junke Mou, Mengyang Wang, Yuehong Wang, Xing Luo, Changqing Xu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Nanobiotechnology
Subjects:
Atherosclerosis
Ferroptosis
Nanoparticles
Macrophage
Online Access:https://doi.org/10.1186/s12951-025-03271-8
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