Widely dispersed clonal expansion of multi-fungicide-resistant Aspergillus fumigatus limits genomic epidemiology prospects

Widely dispersed clonal expansion of multi-fungicide-resistant Aspergillus fumigatus limits genomic epidemiology prospects

ABSTRACT Invasive aspergillosis, caused by Aspergillus fumigatus, represents a critical public health concern, particularly due to increasing resistance to triazole antifungals linked to TR34/TR46 cyp51A haplotypes. In our genomic epidemiology study of 157 A. fumigatus isolates from Dutch environmen...

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Main Authors: Eveline Snelders, Brandi N. Celia-Sanchez, Ymke C. Nederlof, Jianhua Zhang, Hylke H. Kortenbosch, Bas J. Zwaan, Marlou Tehupeiory-Kooreman, Alejandra Giraldo-López, Karin van Dijk, Li Wang, Marin T. Brewer, Michelle Momany, Ben Auxier, Paul E. Verweij
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mBio
Subjects:
genomic epidemiology
Aspergillus fumigatus
antifungal resistance
triazoles
whole genome sequencing
source tracing
Online Access:https://journals.asm.org/doi/10.1128/mbio.03652-24
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