Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice
Stimulation of phosphoinositide hydrolysis in myocardium from autoimmune myocarditis mice by ThEA and histamine was assayed. Myocardium from autoimmune heart, but not the normal forms, specifically increased phosphoinositide turnover in the presence of histaminergic agonists. This increment was bloc...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1993-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935193000444 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849308751146778624 |
|---|---|
| author | Nora Goren Claudia Perez Leiros Leonor Sterin-Borda Enri S. Borda |
| author_facet | Nora Goren Claudia Perez Leiros Leonor Sterin-Borda Enri S. Borda |
| author_sort | Nora Goren |
| collection | DOAJ |
| description | Stimulation of phosphoinositide hydrolysis in myocardium from autoimmune myocarditis mice by ThEA and histamine was assayed. Myocardium from autoimmune heart, but not the normal forms, specifically increased phosphoinositide turnover in the presence of histaminergic agonists. This increment was blocked by a specific H1 antagonist mepyramine and to the same extent by the phospholipase C inhibitor NCDC. By using a binding assay H1 histaminergic receptors were detected in autoimmune heart membrane preparations, but this was not observed in normal heart. These data suggest that autoimmune myocardium expressed a functional H1 receptor that could involve a distinctive mechanism operating in the disease. |
| format | Article |
| id | doaj-art-1a8d55ef6ef344d9bd2442557c8a95aa |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1993-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1a8d55ef6ef344d9bd2442557c8a95aa2025-08-20T03:54:23ZengWileyMediators of Inflammation0962-93511466-18611993-01-012431732210.1155/S0962935193000444Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis miceNora Goren0Claudia Perez Leiros1Leonor Sterin-Borda2Enri S. Borda3Centro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET), Serrano 665, Buenos Aires 1414, ArgentinaCentro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET), Serrano 665, Buenos Aires 1414, ArgentinaCentro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET), Serrano 665, Buenos Aires 1414, ArgentinaCentro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET), Serrano 665, Buenos Aires 1414, ArgentinaStimulation of phosphoinositide hydrolysis in myocardium from autoimmune myocarditis mice by ThEA and histamine was assayed. Myocardium from autoimmune heart, but not the normal forms, specifically increased phosphoinositide turnover in the presence of histaminergic agonists. This increment was blocked by a specific H1 antagonist mepyramine and to the same extent by the phospholipase C inhibitor NCDC. By using a binding assay H1 histaminergic receptors were detected in autoimmune heart membrane preparations, but this was not observed in normal heart. These data suggest that autoimmune myocardium expressed a functional H1 receptor that could involve a distinctive mechanism operating in the disease.http://dx.doi.org/10.1155/S0962935193000444 |
| spellingShingle | Nora Goren Claudia Perez Leiros Leonor Sterin-Borda Enri S. Borda Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice Mediators of Inflammation |
| title | Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice |
| title_full | Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice |
| title_fullStr | Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice |
| title_full_unstemmed | Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice |
| title_short | Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice |
| title_sort | phosphoinositide hydrolysis mediated by h1 receptors in autoimmune myocarditis mice |
| url | http://dx.doi.org/10.1155/S0962935193000444 |
| work_keys_str_mv | AT noragoren phosphoinositidehydrolysismediatedbyh1receptorsinautoimmunemyocarditismice AT claudiaperezleiros phosphoinositidehydrolysismediatedbyh1receptorsinautoimmunemyocarditismice AT leonorsterinborda phosphoinositidehydrolysismediatedbyh1receptorsinautoimmunemyocarditismice AT enrisborda phosphoinositidehydrolysismediatedbyh1receptorsinautoimmunemyocarditismice |