Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findings
Background: Epidemiological data indicate an association between cadmium exposure and risk of bone fracture; however, clinical treatment of cadmium-induced fracture is limited. Although vitamin C (VC) reportedly reduces cadmium-induced fracture, its pharmacological mechanism remains unexplored. Meth...
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Tsinghua University Press
2022-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022000647 |
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| author | Rong Li Songzuo Yu Xiao Liang Yu Li Keng Po Lai |
| author_facet | Rong Li Songzuo Yu Xiao Liang Yu Li Keng Po Lai |
| author_sort | Rong Li |
| collection | DOAJ |
| description | Background: Epidemiological data indicate an association between cadmium exposure and risk of bone fracture; however, clinical treatment of cadmium-induced fracture is limited. Although vitamin C (VC) reportedly reduces cadmium-induced fracture, its pharmacological mechanism remains unexplored. Methods: Thus, we used a network pharmacology approach and molecular docking analysis to identify core targets, functional processes, and biological pathways involved in the anti-fracture action of VC. Results: Bioinformatics identified 17 intersection targets of VC and cadmium-induced fracture. Nine core targets were characterized, including tumor protein p53, epidermal growth factor receptor, proto-oncogene c, mitogen-activated protein kinase-1 (MAPK1), MAPK3, signal transducer and activator of transcription-3, MAPK14, prostaglandin-endoperoxide synthase 2, and estrogen receptor alpha. Interestingly, findings of molecular docking analysis indicated that VC exerted effective binding capacity in cadmium-induced fracture. Furthermore, biological processes, cell components, molecular functions, and pharmacological pathways involved in the action of VC against cadmium-induced fracture were identified and visualized. Conclusions: Based on these findings, we conclude that VC exhibits its anti-cadmium-induced fracture effects by promoting osteoblastic regeneration and proliferation, and inhibiting inflammatory stress. The core targets may serve as biomarkers for diagnosing cadmium-induced fractures. |
| format | Article |
| id | doaj-art-1a8749788b4b433b8016abb78274a56c |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-1a8749788b4b433b8016abb78274a56c2025-02-03T05:16:11ZengTsinghua University PressFood Science and Human Wellness2213-45302022-09-0111513841391Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findingsRong Li0Songzuo Yu1Xiao Liang2Yu Li3Keng Po Lai4Laboratory of Environmental Pollution and Integrative Omics, Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541004, ChinaDepartment of Neurosurgery, Guigang City People's Hospital, The Eighth Affiliated Hospital of Guangxi Medical University, Guigang 537100, ChinaLaboratory of Environmental Pollution and Integrative Omics, Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541004, ChinaLaboratory of Environmental Pollution and Integrative Omics, Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541004, ChinaLaboratory of Environmental Pollution and Integrative Omics, Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541004, China; Corresponding author at: Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541004, ChinaBackground: Epidemiological data indicate an association between cadmium exposure and risk of bone fracture; however, clinical treatment of cadmium-induced fracture is limited. Although vitamin C (VC) reportedly reduces cadmium-induced fracture, its pharmacological mechanism remains unexplored. Methods: Thus, we used a network pharmacology approach and molecular docking analysis to identify core targets, functional processes, and biological pathways involved in the anti-fracture action of VC. Results: Bioinformatics identified 17 intersection targets of VC and cadmium-induced fracture. Nine core targets were characterized, including tumor protein p53, epidermal growth factor receptor, proto-oncogene c, mitogen-activated protein kinase-1 (MAPK1), MAPK3, signal transducer and activator of transcription-3, MAPK14, prostaglandin-endoperoxide synthase 2, and estrogen receptor alpha. Interestingly, findings of molecular docking analysis indicated that VC exerted effective binding capacity in cadmium-induced fracture. Furthermore, biological processes, cell components, molecular functions, and pharmacological pathways involved in the action of VC against cadmium-induced fracture were identified and visualized. Conclusions: Based on these findings, we conclude that VC exhibits its anti-cadmium-induced fracture effects by promoting osteoblastic regeneration and proliferation, and inhibiting inflammatory stress. The core targets may serve as biomarkers for diagnosing cadmium-induced fractures.http://www.sciencedirect.com/science/article/pii/S2213453022000647CadmiumFractureVitamin CNetwork pharmacologyMechanism |
| spellingShingle | Rong Li Songzuo Yu Xiao Liang Yu Li Keng Po Lai Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findings Food Science and Human Wellness Cadmium Fracture Vitamin C Network pharmacology Mechanism |
| title | Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findings |
| title_full | Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findings |
| title_fullStr | Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findings |
| title_full_unstemmed | Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findings |
| title_short | Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findings |
| title_sort | vitamin c exerts anti cadmium induced fracture functions targets bioinformatic and biostructural findings |
| topic | Cadmium Fracture Vitamin C Network pharmacology Mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022000647 |
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