Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors
Tumor sections from nonneoplastic (n=15), benign (n=28), and malignant ovarian tumors (n=20) were obtained from 63 women. Immunohistochemistry of the tumor sections demonstrated that inducible nitric oxide synthase (iNOS) expression was increased in ovarian cancer samples compared to nonneoplastic o...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2008-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2008/186584 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849308744693841920 |
|---|---|
| author | Rosekeila Simões Nomelini Lívia Carolina de Abreu Ribeiro Beatriz Martins Tavares-Murta Sheila Jorge Adad Eddie Fernando Candido Murta |
| author_facet | Rosekeila Simões Nomelini Lívia Carolina de Abreu Ribeiro Beatriz Martins Tavares-Murta Sheila Jorge Adad Eddie Fernando Candido Murta |
| author_sort | Rosekeila Simões Nomelini |
| collection | DOAJ |
| description | Tumor sections from nonneoplastic (n=15), benign (n=28), and malignant ovarian tumors (n=20) were obtained from 63 women. Immunohistochemistry of the tumor sections demonstrated that inducible nitric oxide synthase (iNOS) expression was increased in ovarian cancer samples compared to nonneoplastic or benign tumor samples. Using the Griess method, nitric oxide (NO) metabolite levels were also found to be elevated in malignant tumor samples compared to benign tumor samples (P<.05). For stage I ovarian cancer, intracystic NO levels >80 μM were more frequent than NO levels <80 μM, and iNOS expression in well-differentiated carcinomas was greater than in moderately/poorly differentiated carcinomas (P<.05). These data suggest an important role for NO in ovarian carcinogenesis. |
| format | Article |
| id | doaj-art-1a6fedaa1b2e463d9b82eb2409911de6 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1a6fedaa1b2e463d9b82eb2409911de62025-08-20T03:54:23ZengWileyMediators of Inflammation0962-93511466-18612008-01-01200810.1155/2008/186584186584Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic TumorsRosekeila Simões Nomelini0Lívia Carolina de Abreu Ribeiro1Beatriz Martins Tavares-Murta2Sheila Jorge Adad3Eddie Fernando Candido Murta4Research Institute of Oncology (IPON), Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, 38025-440 Uberaba, MG, BrazilDiscipline of Pharmacology, Federal University of Triângulo Mineiro, 38015-050 Uberaba, MG, BrazilDiscipline of Pharmacology, Federal University of Triângulo Mineiro, 38015-050 Uberaba, MG, BrazilDiscipline of Special Pathology, Federal University of Triângulo Mineiro, 38025-440 Uberaba, MG, BrazilResearch Institute of Oncology (IPON), Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, 38025-440 Uberaba, MG, BrazilTumor sections from nonneoplastic (n=15), benign (n=28), and malignant ovarian tumors (n=20) were obtained from 63 women. Immunohistochemistry of the tumor sections demonstrated that inducible nitric oxide synthase (iNOS) expression was increased in ovarian cancer samples compared to nonneoplastic or benign tumor samples. Using the Griess method, nitric oxide (NO) metabolite levels were also found to be elevated in malignant tumor samples compared to benign tumor samples (P<.05). For stage I ovarian cancer, intracystic NO levels >80 μM were more frequent than NO levels <80 μM, and iNOS expression in well-differentiated carcinomas was greater than in moderately/poorly differentiated carcinomas (P<.05). These data suggest an important role for NO in ovarian carcinogenesis.http://dx.doi.org/10.1155/2008/186584 |
| spellingShingle | Rosekeila Simões Nomelini Lívia Carolina de Abreu Ribeiro Beatriz Martins Tavares-Murta Sheila Jorge Adad Eddie Fernando Candido Murta Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors Mediators of Inflammation |
| title | Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors |
| title_full | Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors |
| title_fullStr | Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors |
| title_full_unstemmed | Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors |
| title_short | Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors |
| title_sort | production of nitric oxide and expression of inducible nitric oxide synthase in ovarian cystic tumors |
| url | http://dx.doi.org/10.1155/2008/186584 |
| work_keys_str_mv | AT rosekeilasimoesnomelini productionofnitricoxideandexpressionofinduciblenitricoxidesynthaseinovariancystictumors AT liviacarolinadeabreuribeiro productionofnitricoxideandexpressionofinduciblenitricoxidesynthaseinovariancystictumors AT beatrizmartinstavaresmurta productionofnitricoxideandexpressionofinduciblenitricoxidesynthaseinovariancystictumors AT sheilajorgeadad productionofnitricoxideandexpressionofinduciblenitricoxidesynthaseinovariancystictumors AT eddiefernandocandidomurta productionofnitricoxideandexpressionofinduciblenitricoxidesynthaseinovariancystictumors |