Plasma/Serum Electrolyte and Metabolite Testing on Blood Gas Analyzer ABL837, a New Application
<b>Background</b>: Core laboratory chemistry analyzers typically use plasma and serum samples, while blood gas instruments use whole blood for electrolyte and metabolite tests. Due to high costs to back up the core lab chemistry analyzers, especially in the remote small community hospita...
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MDPI AG
2025-07-01
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| author | Vera Y. Chen Rachel Fullarton Yu Chen |
| author_facet | Vera Y. Chen Rachel Fullarton Yu Chen |
| author_sort | Vera Y. Chen |
| collection | DOAJ |
| description | <b>Background</b>: Core laboratory chemistry analyzers typically use plasma and serum samples, while blood gas instruments use whole blood for electrolyte and metabolite tests. Due to high costs to back up the core lab chemistry analyzers, especially in the remote small community hospitals, we have verified the interchangeability of serum/plasma electrolytes and metabolites on blood gas instruments (GEM4000 and Radiometer ABL90) vs. chemistry analyzers. In this study, we sought to extend the investigation to another blood gas device—Radiometer ABL837. <b>Methods</b>: One plasma separator tube and one serum separator tube were drawn from 20 apparently healthy individuals and outpatients and 20 intensive care unit patients. All the samples were run on Roche Cobas8000, and then were run on three Radiometer ABL837 analyzers for sodium (Na<sup>+</sup>), potassium (K<sup>+</sup>), chloride (Cl<sup>−</sup>), glucose, lactate (plasma only), and creatinine parameters. Paired measurements between the ABL837 and Cobas8000 were compared, and their difference were assessed for statistical and clinical significance. <b>Results</b>: ABL837 demonstrated statistical significance (<i>p</i> < 0.05) vs. Cobas8000 on all the plasma and serum parameters. However, no parameter differences were found when comparing the plasma/serum results on ABL837 to those on Cobas8000, indicating that none were clinically significant. ABL837 also demonstrated good–excellent correlations with Cobas8000 on all the parameters. <b>Conclusions</b>: When comparing metabolite and electrolyte values with plasma and serum sample types, the ABL837 blood gas instruments and Cobas 8000 chemistry analyzer are interchangeable. These data proves that ABL837 can be used as a backup for a chemistry analyzer in measuring plasma and serum electrolyte and metabolite concentrations. |
| format | Article |
| id | doaj-art-1a6f7464fe634c839366b4cde3824891 |
| institution | DOAJ |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-1a6f7464fe634c839366b4cde38248912025-08-20T03:02:48ZengMDPI AGDiagnostics2075-44182025-07-011515192310.3390/diagnostics15151923Plasma/Serum Electrolyte and Metabolite Testing on Blood Gas Analyzer ABL837, a New ApplicationVera Y. Chen0Rachel Fullarton1Yu Chen2Department of Laboratory Medicine, Dr. Everett Chalmers Regional Hospital, Horizon Health Network, Fredericton, NB E3B 5N5, CanadaDepartment of Laboratory Medicine, Dr. Everett Chalmers Regional Hospital, Horizon Health Network, Fredericton, NB E3B 5N5, CanadaDepartment of Laboratory Medicine, Dr. Everett Chalmers Regional Hospital, Horizon Health Network, Fredericton, NB E3B 5N5, Canada<b>Background</b>: Core laboratory chemistry analyzers typically use plasma and serum samples, while blood gas instruments use whole blood for electrolyte and metabolite tests. Due to high costs to back up the core lab chemistry analyzers, especially in the remote small community hospitals, we have verified the interchangeability of serum/plasma electrolytes and metabolites on blood gas instruments (GEM4000 and Radiometer ABL90) vs. chemistry analyzers. In this study, we sought to extend the investigation to another blood gas device—Radiometer ABL837. <b>Methods</b>: One plasma separator tube and one serum separator tube were drawn from 20 apparently healthy individuals and outpatients and 20 intensive care unit patients. All the samples were run on Roche Cobas8000, and then were run on three Radiometer ABL837 analyzers for sodium (Na<sup>+</sup>), potassium (K<sup>+</sup>), chloride (Cl<sup>−</sup>), glucose, lactate (plasma only), and creatinine parameters. Paired measurements between the ABL837 and Cobas8000 were compared, and their difference were assessed for statistical and clinical significance. <b>Results</b>: ABL837 demonstrated statistical significance (<i>p</i> < 0.05) vs. Cobas8000 on all the plasma and serum parameters. However, no parameter differences were found when comparing the plasma/serum results on ABL837 to those on Cobas8000, indicating that none were clinically significant. ABL837 also demonstrated good–excellent correlations with Cobas8000 on all the parameters. <b>Conclusions</b>: When comparing metabolite and electrolyte values with plasma and serum sample types, the ABL837 blood gas instruments and Cobas 8000 chemistry analyzer are interchangeable. These data proves that ABL837 can be used as a backup for a chemistry analyzer in measuring plasma and serum electrolyte and metabolite concentrations.https://www.mdpi.com/2075-4418/15/15/1923blood gaselectrolytemetaboliteplasmaserumcomparison study |
| spellingShingle | Vera Y. Chen Rachel Fullarton Yu Chen Plasma/Serum Electrolyte and Metabolite Testing on Blood Gas Analyzer ABL837, a New Application Diagnostics blood gas electrolyte metabolite plasma serum comparison study |
| title | Plasma/Serum Electrolyte and Metabolite Testing on Blood Gas Analyzer ABL837, a New Application |
| title_full | Plasma/Serum Electrolyte and Metabolite Testing on Blood Gas Analyzer ABL837, a New Application |
| title_fullStr | Plasma/Serum Electrolyte and Metabolite Testing on Blood Gas Analyzer ABL837, a New Application |
| title_full_unstemmed | Plasma/Serum Electrolyte and Metabolite Testing on Blood Gas Analyzer ABL837, a New Application |
| title_short | Plasma/Serum Electrolyte and Metabolite Testing on Blood Gas Analyzer ABL837, a New Application |
| title_sort | plasma serum electrolyte and metabolite testing on blood gas analyzer abl837 a new application |
| topic | blood gas electrolyte metabolite plasma serum comparison study |
| url | https://www.mdpi.com/2075-4418/15/15/1923 |
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