Changes in various forms of fibronectin in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass – a prospective, observational study
Abstract Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) is associated with the transient activation of a systemic inflammatory response. Fibronectin (FN), an endogenous inflammatory mediator, is a key component of the extracellular matrix. This study aimed to detect changes...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-80765-9 |
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| author | Anna Lemańska-Perek Dorota Krzyżanowska-Gołąb Grzegorz Wysoczański Barbara Barteczko-Grajek Waldemar Goździk Barbara Adamik |
| author_facet | Anna Lemańska-Perek Dorota Krzyżanowska-Gołąb Grzegorz Wysoczański Barbara Barteczko-Grajek Waldemar Goździk Barbara Adamik |
| author_sort | Anna Lemańska-Perek |
| collection | DOAJ |
| description | Abstract Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) is associated with the transient activation of a systemic inflammatory response. Fibronectin (FN), an endogenous inflammatory mediator, is a key component of the extracellular matrix. This study aimed to detect changes in cellular and plasma FN levels, as well as its potential fragmentation or FN-fibrin complex formation, in 40 patients undergoing CABG with CPB. Our results indicate that CPB was associated with changes in the levels of cellular and plasma FN and with intensified FN fragmentation. Moreover, FN-fibrin complexes were detected in all patients, indicating activation of the coagulation process during CPB. In a multivariate regression analysis, a history of arterial hypertension and CPB duration influenced plasma FN levels at 6 h (β = -0.458, p = 0.001; -0.375, p = 0.008, respectively) and 12 h (β = -0.293, p = 0.026; -0.554, p = 0.000) after surgery. Alterations in FN concentration, intensified FN degradation, and the presence of FN-fibrin complexes after surgery may suggest that these changes are related to the remodelling of the extracellular matrix resulting from cardiac surgery and the associated repair processes. The results indicate that FN has clinical potential as a marker of repair processes. |
| format | Article |
| id | doaj-art-1a6bdaa96cfc44ada07b7b39c87b738b |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-1a6bdaa96cfc44ada07b7b39c87b738b2025-08-20T02:43:24ZengNature PortfolioScientific Reports2045-23222024-12-0114111310.1038/s41598-024-80765-9Changes in various forms of fibronectin in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass – a prospective, observational studyAnna Lemańska-Perek0Dorota Krzyżanowska-Gołąb1Grzegorz Wysoczański2Barbara Barteczko-Grajek3Waldemar Goździk4Barbara Adamik5Department of Chemistry and Immunochemistry, Wroclaw Medical UniversityDepartment of Chemistry and Immunochemistry, Wroclaw Medical UniversityUniversity Clinical HospitalClinical Department of Anesthesiology and Intensive Therapy, Wroclaw Medical UniversityClinical Department of Anesthesiology and Intensive Therapy, Wroclaw Medical UniversityClinical Department of Anesthesiology and Intensive Therapy, Wroclaw Medical UniversityAbstract Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) is associated with the transient activation of a systemic inflammatory response. Fibronectin (FN), an endogenous inflammatory mediator, is a key component of the extracellular matrix. This study aimed to detect changes in cellular and plasma FN levels, as well as its potential fragmentation or FN-fibrin complex formation, in 40 patients undergoing CABG with CPB. Our results indicate that CPB was associated with changes in the levels of cellular and plasma FN and with intensified FN fragmentation. Moreover, FN-fibrin complexes were detected in all patients, indicating activation of the coagulation process during CPB. In a multivariate regression analysis, a history of arterial hypertension and CPB duration influenced plasma FN levels at 6 h (β = -0.458, p = 0.001; -0.375, p = 0.008, respectively) and 12 h (β = -0.293, p = 0.026; -0.554, p = 0.000) after surgery. Alterations in FN concentration, intensified FN degradation, and the presence of FN-fibrin complexes after surgery may suggest that these changes are related to the remodelling of the extracellular matrix resulting from cardiac surgery and the associated repair processes. The results indicate that FN has clinical potential as a marker of repair processes.https://doi.org/10.1038/s41598-024-80765-9FibronectinEDA-FNFN-fibrin complexesCardiopulmonary bypassInflammation |
| spellingShingle | Anna Lemańska-Perek Dorota Krzyżanowska-Gołąb Grzegorz Wysoczański Barbara Barteczko-Grajek Waldemar Goździk Barbara Adamik Changes in various forms of fibronectin in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass – a prospective, observational study Scientific Reports Fibronectin EDA-FN FN-fibrin complexes Cardiopulmonary bypass Inflammation |
| title | Changes in various forms of fibronectin in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass – a prospective, observational study |
| title_full | Changes in various forms of fibronectin in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass – a prospective, observational study |
| title_fullStr | Changes in various forms of fibronectin in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass – a prospective, observational study |
| title_full_unstemmed | Changes in various forms of fibronectin in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass – a prospective, observational study |
| title_short | Changes in various forms of fibronectin in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass – a prospective, observational study |
| title_sort | changes in various forms of fibronectin in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass a prospective observational study |
| topic | Fibronectin EDA-FN FN-fibrin complexes Cardiopulmonary bypass Inflammation |
| url | https://doi.org/10.1038/s41598-024-80765-9 |
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