Strategic multimodal intervention in at-risk elderly Indians for prevention of dementia (SMRUTHI INDIA): a cohort multiple randomised controlled trial (cmRCT) protocol

Strategic multimodal intervention in at-risk elderly Indians for prevention of dementia (SMRUTHI INDIA): a cohort multiple randomised controlled trial (cmRCT) protocol

Introduction Treating modifiable risk factors of dementia may prevent or delay dementia cases by up to 40%. The ‘Strategic Multimodal Intervention in at-risk Elderly Indians for Prevention of Dementia (SMRUTHI INDIA)’ study will be conducted to establish a trial-ready cohort of elderly Indians who a...

Full description

Saved in:
Bibliographic Details
Main Authors: Pooja Sharma, Divyani Garg, Maroof Ahmad Khan, Ayush Agarwal, Manish Barvaliya, Shubham Gupta, Alex Rebello, Ashima Nehra, Anu Gupta, Padma Srivastava, Kritika Sharma, Subrata Baidya, Abhik Sinha, Shampa Das, Sunil Kumar Raina, Sakshi Sharma, Venugopalan Y Vishnu, Varuna Sharma, Subarna Roy, P K Anand, Nilima Nilima, Vaibhav Patil, Rajeev Aggarwal, Aditi Dubey, Hina Narzari, Sneha Sneha, Kamini Kashyap, Krishan Kaushal, Kajal Fulara, Shikha Chaudhary, Divya M R, Vasundhara Misra, Phaniraj Vastrad, Priyadarshanraj N, Sandesh J R, Harshath Ajay V, Aishwarya Bhovi, Mailrappa Padiyappa Hooli, Sagar P M, Ambika Y V, Ripanjit Singh, Naveen M R, Shilpa K, Sharanabasavaraj Devaramani, Sandip Bhattacharjee, Bishakha Sen, Shalina Jamatia, Manish Acharjee, Dipankar Deb, Pameli Jamatia, Munmun Debbarma, Shaily Bhushan, Rishabh Gautam, Rishav Bhatia, Arnav Verma, Kalpna Sharma, Gajraj Singh, Priyanka Kumari Meena, Akhilesh Nagar, Hitesh Tiwari, Tinku Yogi, Vikram Raigar, Vinny Wilson, Shradha Singh, Zubia Nasir, Daksha Kumari, Mallamma Duddagi, Basamma R Alur, Sreetama Bahaduri, Aditya Choudhary, Suhas Murali, Jyoti Kattna, Amita Sengupta, Dolan Roy, Tithi Patra, Bandana Kayestha, Yachana Sharma, Nandini Rawat, Kavita Bairwa, Muskan Sharma, Divyani Rathore
Format: Article
Language:English
Published: BMJ Publishing Group 2025-06-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/6/e084050.full
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Treating modifiable risk factors of dementia may prevent or delay dementia cases by up to 40%. The ‘Strategic Multimodal Intervention in at-risk Elderly Indians for Prevention of Dementia (SMRUTHI INDIA)’ study will be conducted to establish a trial-ready cohort of elderly Indians who are at high risk of developing dementia.Methods and analysis The main aim of the study is to create and study a cohort of individuals at high risk of dementia in rural India, where we can do multiple intervention trials. The study uses the ‘Cohort Multiple Randomised Controlled Trial’ (cmRCT) design, which combines a cohort study with in-built provisions to do multiple randomised controlled trials. A large rural cohort of size 10 000 (four zones of India, through established Indian Council of Medical Research - Model Rural Health Research Units) will be followed systematically with yearly neuropsychological evaluation for 5 years (the current funding supports first 3000 participants). The study also proposes to design a multimodal ‘care bundle’ for the prevention of dementia, which is culturally tailored and context-specific to the Indian population. This intervention will undergo testing for feasibility in the hospital setting at the central coordinating site through a pilot randomised controlled trial (6 months, 30 participants). In parallel, the care bundle will be culturally and linguistically adapted and pilot-tested in 20 participants in each zone. The final curated care bundle (first intervention that is planned) will then be tested for efficacy in phase 2 of the SMRUTHI INDIA cmRCT cohort.Ethics and dissemination The study has received ethical clearance at the central coordinating site and at each of the four clinical sites by the Institute Research Committee of each site. The outcomes of the study will be disseminated to various target audiences, including research participants, general public, scientific community and policy makers through national and international conferences and events, social media, various community engagement activities and publication in peer-reviewed journals.Trial registration number The study protocol is registered in the Clinical Trial Registry of India (CTRI/2024/01/061172).
ISSN:2044-6055

Similar Items