The role of BMAL1 in glial cells: Implications for cognitive function in neurodegenerative diseases
Disruption of the circadian rhythm may precede the typical clinical symptoms of neurodegenerative diseases and is a potential risk factor for Alzheimer’s disease (AD), associated dementias, and Parkinson’s disease (PD). The morphology and function of mammalian glial cells and their gene expression c...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025002758 |
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| author | Zhimin Ding Yueyang Zhuang Jiawei Jian Tao Jiang Jiayi Huang Minguang Yang Lei Yang Weilin Liu |
| author_facet | Zhimin Ding Yueyang Zhuang Jiawei Jian Tao Jiang Jiayi Huang Minguang Yang Lei Yang Weilin Liu |
| author_sort | Zhimin Ding |
| collection | DOAJ |
| description | Disruption of the circadian rhythm may precede the typical clinical symptoms of neurodegenerative diseases and is a potential risk factor for Alzheimer’s disease (AD), associated dementias, and Parkinson’s disease (PD). The morphology and function of mammalian glial cells and their gene expression correlate with circadian rhythms. Brain and muscle Arnt-like protein-1(BMAL1) is a core player in the functional regulation of glial cells and is a major regulator of circadian rhythms. According to new research, neuroglial BMAL1 is implicated in several pathological processes, including altered energy metabolism, dysregulated protein homeostasis, decreased synaptic plasticity, disrupted myelin formation and regeneration, and neuroinflammation, which are correlated with cognitive impairment in neurodegenerative diseases. To provide concepts and perspectives for precision medicine of the disease, we have systematically summarized the mechanism of action of neuroglial BMAL1 in cognitive impairment in neurodegenerative diseases and related studies, established a signaling network map between neuroglial BMAL1 and cognitive impairment, and discussed therapeutic strategies targeting neuroglial BMAL1. |
| format | Article |
| id | doaj-art-1a6a5e96ae7f4c7cb36891e4bd0652fe |
| institution | DOAJ |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-1a6a5e96ae7f4c7cb36891e4bd0652fe2025-08-20T02:49:29ZengElsevierBrain Research Bulletin1873-27472025-09-0122911146310.1016/j.brainresbull.2025.111463The role of BMAL1 in glial cells: Implications for cognitive function in neurodegenerative diseasesZhimin Ding0Yueyang Zhuang1Jiawei Jian2Tao Jiang3Jiayi Huang4Minguang Yang5Lei Yang6Weilin Liu7College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; The Institute of Rehabilitation Industry, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; The Institute of Rehabilitation Industry, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; The Institute of Rehabilitation Industry, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; The Institute of Rehabilitation Industry, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaThe Institute of Rehabilitation Industry, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaThe Institute of Rehabilitation Industry, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; The Institute of Rehabilitation Industry, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Corresponding author at: College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.Disruption of the circadian rhythm may precede the typical clinical symptoms of neurodegenerative diseases and is a potential risk factor for Alzheimer’s disease (AD), associated dementias, and Parkinson’s disease (PD). The morphology and function of mammalian glial cells and their gene expression correlate with circadian rhythms. Brain and muscle Arnt-like protein-1(BMAL1) is a core player in the functional regulation of glial cells and is a major regulator of circadian rhythms. According to new research, neuroglial BMAL1 is implicated in several pathological processes, including altered energy metabolism, dysregulated protein homeostasis, decreased synaptic plasticity, disrupted myelin formation and regeneration, and neuroinflammation, which are correlated with cognitive impairment in neurodegenerative diseases. To provide concepts and perspectives for precision medicine of the disease, we have systematically summarized the mechanism of action of neuroglial BMAL1 in cognitive impairment in neurodegenerative diseases and related studies, established a signaling network map between neuroglial BMAL1 and cognitive impairment, and discussed therapeutic strategies targeting neuroglial BMAL1.http://www.sciencedirect.com/science/article/pii/S0361923025002758Neurodegenerative diseasesARNTL transcription factorsCircadian rhythmGlial cellsCognitive impairment |
| spellingShingle | Zhimin Ding Yueyang Zhuang Jiawei Jian Tao Jiang Jiayi Huang Minguang Yang Lei Yang Weilin Liu The role of BMAL1 in glial cells: Implications for cognitive function in neurodegenerative diseases Brain Research Bulletin Neurodegenerative diseases ARNTL transcription factors Circadian rhythm Glial cells Cognitive impairment |
| title | The role of BMAL1 in glial cells: Implications for cognitive function in neurodegenerative diseases |
| title_full | The role of BMAL1 in glial cells: Implications for cognitive function in neurodegenerative diseases |
| title_fullStr | The role of BMAL1 in glial cells: Implications for cognitive function in neurodegenerative diseases |
| title_full_unstemmed | The role of BMAL1 in glial cells: Implications for cognitive function in neurodegenerative diseases |
| title_short | The role of BMAL1 in glial cells: Implications for cognitive function in neurodegenerative diseases |
| title_sort | role of bmal1 in glial cells implications for cognitive function in neurodegenerative diseases |
| topic | Neurodegenerative diseases ARNTL transcription factors Circadian rhythm Glial cells Cognitive impairment |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025002758 |
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