Predictive value of Frank’s sign for obstructive coronary artery disease confirmed by coronary computed tomography angiography
Numerous studies have suggested a link between Frank’s sign and coronary artery disease (CAD); however, there is limited data available from Southeast Asia, and no previous studies have been conducted in Vietnam to evaluate this association. This cross-sectional study examined 124 consecutive Vietn...
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| Language: | English |
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PAGEPress Publications
2025-02-01
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| Series: | Italian Journal of Medicine |
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| Online Access: | https://www.italjmed.org/ijm/article/view/1863 |
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| author | Truong Phi Hung Nguyen Minh Kha Dang Tuong Vi Tran Trong Nhan Hoang Van Sy |
| author_facet | Truong Phi Hung Nguyen Minh Kha Dang Tuong Vi Tran Trong Nhan Hoang Van Sy |
| author_sort | Truong Phi Hung |
| collection | DOAJ |
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Numerous studies have suggested a link between Frank’s sign and coronary artery disease (CAD); however, there is limited data available from Southeast Asia, and no previous studies have been conducted in Vietnam to evaluate this association. This cross-sectional study examined 124 consecutive Vietnamese individuals who underwent coronary computed tomography angiography at our center. Differences in patient characteristics and the association between Frank’s sign and CAD were analyzed using Chi-square and t-tests. Multivariate regression was performed to adjust for confounding variables, and receiver operating characteristic curve analysis was utilized to evaluate the predictive accuracy of Frank’s sign for CAD. In this study, 124 patients with a mean age of 58.5±12.4 years, predominantly male, were included. Frank’s sign was present in 84% of the participants. Among these, males and older individuals had significantly higher rates compared to those without the sign. Obstructive CAD was observed in 48 patients (38.7%). The prevalence of obstructive CAD was significantly higher in those with Frank’s sign (52.5%) compared to those without it (13.6%), with p<0.001. Multivariate analysis identified Frank’s sign [odds ratio (OR) 3.79; 95% confidence interval (CI) 1.33-10.82] and age (OR 1.06; 95% CI 1.01-1.10) as independent risk factors for CAD. Frank’s sign demonstrated an area under the curve of 0.69, with 88% sensitivity and 50% specificity in predicting CAD. This study highlights a significant association between Frank’s sign and CAD, independent of established risk factors, in a Vietnamese population.
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| format | Article |
| id | doaj-art-1a6692fb3e0843b789ac1a2d267bf5fc |
| institution | Kabale University |
| issn | 1877-9344 1877-9352 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | PAGEPress Publications |
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| series | Italian Journal of Medicine |
| spelling | doaj-art-1a6692fb3e0843b789ac1a2d267bf5fc2025-02-08T02:38:34ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522025-02-0119110.4081/itjm.2025.1863Predictive value of Frank’s sign for obstructive coronary artery disease confirmed by coronary computed tomography angiographyTruong Phi Hung0Nguyen Minh Kha1Dang Tuong Vi2Tran Trong Nhan3Hoang Van Sy4Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City; Department of Cardiology, Cho Ray Hospital, Ho Chi Minh CityDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City; Department of Cardiology, Cho Ray Hospital, Ho Chi Minh CityDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh CityDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh CityDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City; Department of Cardiology, Cho Ray Hospital, Ho Chi Minh City Numerous studies have suggested a link between Frank’s sign and coronary artery disease (CAD); however, there is limited data available from Southeast Asia, and no previous studies have been conducted in Vietnam to evaluate this association. This cross-sectional study examined 124 consecutive Vietnamese individuals who underwent coronary computed tomography angiography at our center. Differences in patient characteristics and the association between Frank’s sign and CAD were analyzed using Chi-square and t-tests. Multivariate regression was performed to adjust for confounding variables, and receiver operating characteristic curve analysis was utilized to evaluate the predictive accuracy of Frank’s sign for CAD. In this study, 124 patients with a mean age of 58.5±12.4 years, predominantly male, were included. Frank’s sign was present in 84% of the participants. Among these, males and older individuals had significantly higher rates compared to those without the sign. Obstructive CAD was observed in 48 patients (38.7%). The prevalence of obstructive CAD was significantly higher in those with Frank’s sign (52.5%) compared to those without it (13.6%), with p<0.001. Multivariate analysis identified Frank’s sign [odds ratio (OR) 3.79; 95% confidence interval (CI) 1.33-10.82] and age (OR 1.06; 95% CI 1.01-1.10) as independent risk factors for CAD. Frank’s sign demonstrated an area under the curve of 0.69, with 88% sensitivity and 50% specificity in predicting CAD. This study highlights a significant association between Frank’s sign and CAD, independent of established risk factors, in a Vietnamese population. https://www.italjmed.org/ijm/article/view/1863 Coronary artery diseaseFrank’s signCCTA |
| spellingShingle | Truong Phi Hung Nguyen Minh Kha Dang Tuong Vi Tran Trong Nhan Hoang Van Sy Predictive value of Frank’s sign for obstructive coronary artery disease confirmed by coronary computed tomography angiography Italian Journal of Medicine Coronary artery disease Frank’s sign CCTA |
| title | Predictive value of Frank’s sign for obstructive coronary artery disease confirmed by coronary computed tomography angiography |
| title_full | Predictive value of Frank’s sign for obstructive coronary artery disease confirmed by coronary computed tomography angiography |
| title_fullStr | Predictive value of Frank’s sign for obstructive coronary artery disease confirmed by coronary computed tomography angiography |
| title_full_unstemmed | Predictive value of Frank’s sign for obstructive coronary artery disease confirmed by coronary computed tomography angiography |
| title_short | Predictive value of Frank’s sign for obstructive coronary artery disease confirmed by coronary computed tomography angiography |
| title_sort | predictive value of frank s sign for obstructive coronary artery disease confirmed by coronary computed tomography angiography |
| topic | Coronary artery disease Frank’s sign CCTA |
| url | https://www.italjmed.org/ijm/article/view/1863 |
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