NR4A1 suppresses breast cancer growth by repressing c-Fos-mediated lipid and redox dyshomeostasis

NR4A1 suppresses breast cancer growth by repressing c-Fos-mediated lipid and redox dyshomeostasis

Abstract The specific function of NR4A1 as a transcriptional regulator in cancer remains unclear. Here we report the biological effect of NR4A1 in suppressing breast cancer (BC) growth. We found that NR4A1 deficiency was correlated with BC progression in the clinic. Genetic deletion of NR4A1 in BC c...

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Bibliographic Details
Main Authors: Cen Jiang, Youzhi Zhu, Junsi Zhang, Huaying Chen, Weiwei Li, Ruiwang Xie, Lingjun Kong, Ling Chen, Xiangjin Chen, Huifang Huang, Sunwang Xu
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01430-3
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