Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection
Background. Information regarding the progression of acute hepatitis B virus (HBV) infection to chronic infection in adults is scarce. Methods. Twenty-five adult patients with acute HBV infection (14 men and 11 women, 18–84 years old), whose clinical features progressed to those of chronic infection...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2014/358206 |
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| author | Kojiro Michitaka Atsushi Hiraoka Yoshio Tokumoto Keiko Ninomiya Tomoyuki Ninomiya Norio Horiike Masanori Abe Yoichi Hiasa |
| author_facet | Kojiro Michitaka Atsushi Hiraoka Yoshio Tokumoto Keiko Ninomiya Tomoyuki Ninomiya Norio Horiike Masanori Abe Yoichi Hiasa |
| author_sort | Kojiro Michitaka |
| collection | DOAJ |
| description | Background. Information regarding the progression of acute hepatitis B virus (HBV) infection to chronic infection in adults is scarce. Methods. Twenty-five adult patients with acute HBV infection (14 men and 11 women, 18–84 years old), whose clinical features progressed to those of chronic infection (group A) or did not (group B), were studied retrospectively. Results. There were 3 and 22 patients in groups A and B, respectively. Two of the 3 patients of group A lacked the typical symptoms of acute hepatitis. No differences were found between groups with respect to age, sex, or HBV genotypes. However, total bilirubin and alanine aminotransaminase levels were significantly lower in group A. Conclusions. Three of the 25 adult patients with acute HBV infection progressed to chronic infection. Hepatitis was mild in these patients. Patients with mild acute hepatitis B or unapparent HBV infection may have a higher risk of progressing to chronic infection. |
| format | Article |
| id | doaj-art-1a5b8090048d446e9617e87fdfd52ed3 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-1a5b8090048d446e9617e87fdfd52ed32025-02-03T06:12:03ZengWileyInternational Journal of Hepatology2090-34482090-34562014-01-01201410.1155/2014/358206358206Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic InfectionKojiro Michitaka0Atsushi Hiraoka1Yoshio Tokumoto2Keiko Ninomiya3Tomoyuki Ninomiya4Norio Horiike5Masanori Abe6Yoichi Hiasa7Gastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, JapanGastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, JapanDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon 791-0295, JapanGastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, JapanGastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, JapanDepartment of Internal Medicine, Saiseikai Imabari Hospital, Imabari 794-0054, JapanDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon 791-0295, JapanDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon 791-0295, JapanBackground. Information regarding the progression of acute hepatitis B virus (HBV) infection to chronic infection in adults is scarce. Methods. Twenty-five adult patients with acute HBV infection (14 men and 11 women, 18–84 years old), whose clinical features progressed to those of chronic infection (group A) or did not (group B), were studied retrospectively. Results. There were 3 and 22 patients in groups A and B, respectively. Two of the 3 patients of group A lacked the typical symptoms of acute hepatitis. No differences were found between groups with respect to age, sex, or HBV genotypes. However, total bilirubin and alanine aminotransaminase levels were significantly lower in group A. Conclusions. Three of the 25 adult patients with acute HBV infection progressed to chronic infection. Hepatitis was mild in these patients. Patients with mild acute hepatitis B or unapparent HBV infection may have a higher risk of progressing to chronic infection.http://dx.doi.org/10.1155/2014/358206 |
| spellingShingle | Kojiro Michitaka Atsushi Hiraoka Yoshio Tokumoto Keiko Ninomiya Tomoyuki Ninomiya Norio Horiike Masanori Abe Yoichi Hiasa Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection International Journal of Hepatology |
| title | Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection |
| title_full | Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection |
| title_fullStr | Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection |
| title_full_unstemmed | Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection |
| title_short | Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection |
| title_sort | clinical features of adult patients with acute hepatitis b virus infection progressing to chronic infection |
| url | http://dx.doi.org/10.1155/2014/358206 |
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