Expansion of the antibacterial spectrum of symmetrical amino acid-paired antifungal peptides through structural optimization

Expansion of the antibacterial spectrum of symmetrical amino acid-paired antifungal peptides through structural optimization

Abstract Background Fungal infections often co-occur with antibiotic-resistant bacterial infections, posing clinical treatment challenges. Antimicrobial peptides (AMPs) are considered promising therapeutic alternatives due to their low potential for inducing drug resistance. This study aimed to enha...

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Bibliographic Details
Main Authors: Dongyu Gao, Xu Zheng, Jiawen Luo, Shuhe Li, Jiahao Hu, Xue Gao, Tiexiang Zhan, Ziyi Sun, Shuli Chou, Xianguo Zeng, Qingru Jiang, Liang Luo
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Microbiology
Subjects:
Threonine
Resistant bacteria
Resistant fungi
Probiotic
Hydrophobicity
Online Access:https://doi.org/10.1186/s12866-025-04160-8
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