TRANSCRIPTION FACTORS IN CEREBELLAR DEVELOPMENT
The cerebellar germ arises from the rhombic lip, and it’s a rostral part from the mesencephalon. The following cellular processes take place in the developing cerebellum: proliferation, migration, differentiation, synapse formation and cell death. An important step is the transformation of the Pu...
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Trakia University
2023-09-01
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| Series: | Trakia Journal of Sciences |
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| Online Access: | http://tru.uni-sz.bg/tsj/Volume%2021,%202023,%20Number%203,%20Series%20Biomedical%20Sciences/7_I.Velikov.pdf |
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| author | I. Velikov |
| author_facet | I. Velikov |
| author_sort | I. Velikov |
| collection | DOAJ |
| description | The cerebellar germ arises from the rhombic lip, and it’s a rostral part from the mesencephalon. The
following cellular processes take place in the developing cerebellum: proliferation, migration,
differentiation, synapse formation and cell death. An important step is the transformation of the
Purkinje cell layer from a multilayer composition into a monolayer. This structural reorganization
is followed by the foliation process. At first, the smooth surface is divided into five major lobes by
four grooves in the vermis. In the next phase major lobes are subdivided into sublobes and lobules
and they grow in size. The development of granular neurons in the cerebellum takes place in two
phases. The first is in the rhombic lip and the second is in the external granular layer (EGL). The
development is directed by some transcription factors such as sonic hedgehog (Shh), Zbtb, and Pax6. |
| format | Article |
| id | doaj-art-1a53b49fd6754dbaaf80eed53819df10 |
| institution | OA Journals |
| issn | 1313-3551 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Trakia University |
| record_format | Article |
| series | Trakia Journal of Sciences |
| spelling | doaj-art-1a53b49fd6754dbaaf80eed53819df102025-08-20T01:51:35ZengTrakia UniversityTrakia Journal of Sciences1313-35512023-09-0121325726510.15547/tjs.2023.03.007TRANSCRIPTION FACTORS IN CEREBELLAR DEVELOPMENTI. VelikovThe cerebellar germ arises from the rhombic lip, and it’s a rostral part from the mesencephalon. The following cellular processes take place in the developing cerebellum: proliferation, migration, differentiation, synapse formation and cell death. An important step is the transformation of the Purkinje cell layer from a multilayer composition into a monolayer. This structural reorganization is followed by the foliation process. At first, the smooth surface is divided into five major lobes by four grooves in the vermis. In the next phase major lobes are subdivided into sublobes and lobules and they grow in size. The development of granular neurons in the cerebellum takes place in two phases. The first is in the rhombic lip and the second is in the external granular layer (EGL). The development is directed by some transcription factors such as sonic hedgehog (Shh), Zbtb, and Pax6.http://tru.uni-sz.bg/tsj/Volume%2021,%202023,%20Number%203,%20Series%20Biomedical%20Sciences/7_I.Velikov.pdffoliationneurogenesisgranule cellspurkinje cellsrhombic lip |
| spellingShingle | I. Velikov TRANSCRIPTION FACTORS IN CEREBELLAR DEVELOPMENT Trakia Journal of Sciences foliation neurogenesis granule cells purkinje cells rhombic lip |
| title | TRANSCRIPTION FACTORS IN CEREBELLAR DEVELOPMENT |
| title_full | TRANSCRIPTION FACTORS IN CEREBELLAR DEVELOPMENT |
| title_fullStr | TRANSCRIPTION FACTORS IN CEREBELLAR DEVELOPMENT |
| title_full_unstemmed | TRANSCRIPTION FACTORS IN CEREBELLAR DEVELOPMENT |
| title_short | TRANSCRIPTION FACTORS IN CEREBELLAR DEVELOPMENT |
| title_sort | transcription factors in cerebellar development |
| topic | foliation neurogenesis granule cells purkinje cells rhombic lip |
| url | http://tru.uni-sz.bg/tsj/Volume%2021,%202023,%20Number%203,%20Series%20Biomedical%20Sciences/7_I.Velikov.pdf |
| work_keys_str_mv | AT ivelikov transcriptionfactorsincerebellardevelopment |